Zobrazeno 1 - 6
of 6
pro vyhledávání: '"L S Beavers"'
Autor:
Ashraff A. Rampersaud, Archer Ra, T F Bumol, Raymond F. Kauffman, L S Beavers, Ho-Shen Lin, Pawlak Jm, William R. Bensch, Schmidt Rj, L D Apelgren
Publikováno v:
Journal of Medicinal Chemistry. 38:277-288
A new series of sterols was synthesized and tested in a CHO cell-based LDL receptor/luciferase (LDLR/Luc) assay to investigate the capability of derepressing the transcription of LDL receptor promoter in the presence of 25-hydroxycholesterol. The eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91c7a660d1143ede3426f54cb972acc
https://doi.org/10.1021/jm00002a010
https://doi.org/10.1021/jm00002a010
Autor:
H S, Lin, A A, Rampersaud, M E, Richett, R W, Harper, L S, Beavers, D B, McClure, A J, Gardner, P I, Eacho, P S, Foxworthy, R A, Gadski
Publikováno v:
Steroids. 64(3)
4Alpha-(2-propenyl)-5alpha-cholestan-3alpha-ol (LY295427) was previously identified from a Chinese hamster ovary (CHO) cell-based low density lipoprotein receptor/luciferase (LDLR/Luc) assay to be a potent transcriptional activator of the LDL recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0dddee8c7d0ae5cdec48c0c91ffba20b
https://pubmed.ncbi.nlm.nih.gov/10400383
https://pubmed.ncbi.nlm.nih.gov/10400383
Autor:
W R, Bensch, R A, Gadski, J S, Bean, L S, Beavers, R J, Schmidt, D N, Perry, A T, Murphy, D B, McClure, P I, Eacho, A P, Breau, R A, Archer, R F, Kauffman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(1)
The action of LY295427 [(3alpha,4alpha, 5alpha)-4-(2-propenylcholestan-3-ol)], a compound that derepresses low-density lipoprotein receptor (LDL-R) expression in a cell-based model, was examined in hamsters. It was found that the compound does not ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca888bd16650b24487b1853398613497
https://pubmed.ncbi.nlm.nih.gov/10086991
https://pubmed.ncbi.nlm.nih.gov/10086991
Publikováno v:
Steroids. 63(4)
4 alpha-(2-Propenyl)-5 alpha-cholestan-3 alpha-ol (LY295427) was previously identified from a CHO cell-based assay to be a potent LDL receptor up-regulator and had demonstrated to be an effective agent in lowering plasma cholesterol levels in hyperch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2684b61ab7cfc3444c3c1a1297e44107
https://pubmed.ncbi.nlm.nih.gov/9589554
https://pubmed.ncbi.nlm.nih.gov/9589554
Publikováno v:
Molecular pharmacology. 49(2)
The 36-amino acid peptide, neuropeptide Y (NPY), is a member of a peptide family that includes the endocrine peptides, peptide YY (PYY), and pancreatic polypeptide (PP). NPY receptors have been broadly subdivided into postsynaptic Y1 receptors and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f66ba7e141323bbca74ac352dbb2ee10
https://pubmed.ncbi.nlm.nih.gov/8632753
https://pubmed.ncbi.nlm.nih.gov/8632753
Autor:
J, Strnad, A E, Hamilton, L S, Beavers, G C, Gamboa, L D, Apelgren, L D, Taber, J R, Sportsman, T F, Bumol, J D, Sharp, R A, Gadski
Publikováno v:
Cancer research. 49(2)
A human adenocarcinoma-associated antigen (KSA) defined by the monoclonal antibody KS1/4 has become the focus of several site-directed strategies for tumor therapy. KSA, a 40,000 Da cell surface glycoprotein antigen, is found at a high density in all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecd93d4a22c84708fc2441a44e83163b
https://pubmed.ncbi.nlm.nih.gov/2463074
https://pubmed.ncbi.nlm.nih.gov/2463074