Zobrazeno 1 - 10 of 13 pro vyhledávání: '"L S, Steelman"'
1
GSK-3β can regulate the sensitivity of pancreatic cells to chemotherapeutic drugs, targeted therapeutics and nutraceuticals
Autor: S. L. Abrams, S. M. Akula, A. K Meher, L. S. Steelman, A. Gizak, P. Duda, D. Rakus, A. M. Martelli, S. Ratti, L. Cocco, G. Montalto, M. Cervello, P. Ruvolo, M. Libra, L. Falzone, S. Candido, J. A. McCubrey.
Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas-dependent and can be suppressed by GSK-3 inhibitors, documenting a link betwee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4094::ff10e8f2f8eb627ea56477a5983b746a
http://hdl.handle.net/11585/855456
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2
Introduction of WT-TP53 into pancreatic cancer cells with mutant TP53 alters sensitivity of chemotherapeutic drugs, targeted therapeutics and nutraceuticals
Autor: S. L. Abrams, K. Lertpiriyapong, L. V. Yang, A. M. Martelli, L. Cocco, S. Ratti, M. Falasca, R. M. Murata, P. L. Rosalen, P. Lombardi, M. Libra, G. Montalto, M. Cervello, L. S. Steelman, J. A. McCubrey.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5–10%. Mutations at the TP53 gene are readily det
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4094::5a84a3be8cae184498f98940ecc77b62
http://hdl.handle.net/11585/643928
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3
Drug-resistance in FL5.12 doxorubicin-resistant hematopoietic cells: elevated MDR1 and decreased BCL2-family member expression and increased side-population positive cells
Autor: L. S. Steelman, S. L. Abrams, P. Ruvolo, V. Ruvolo, L. Cocco, S. Ratti, A. M. Martelli, L. Neri, S. Candido, M. Libra, J. A. McCubrey.
Chemotherapeutic drug treatment can result in the emergence of drug-resistant cells. By culturing an interleukin-3 (IL-3)-dependent cell line, FL5.12 cells in the presence of the chemotherapeutic drug doxorubicin, we isolated FL/Doxo cells which are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4094::98fe6a00ba8d6508c18214abde8fcf01
http://hdl.handle.net/11585/619773
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5
Synergy between AUUUA motif disruption and enhancer insertion results in autocrine transformation of interleukin-3-dependent hematopoietic cells
Autor: M W, Mayo, X Y, Wang, P A, Algate, G F, Arana, P E, Hoyle, L S, Steelman, J A, McCubrey
Publikováno v: Blood. 86:3139-3150
Previously, we characterized the transposition of an intracisternal type A particle (IAP) to the 32 untranslated region (UTR) of the interleukin-3 (IL-3) gene, which displaced two of the six AUUUA motifs associated with mRNA stability in an IL-3-secr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69bfcb65c3b7f51d7efe105cd70e669
https://doi.org/10.1182/blood.v86.8.3139.bloodjournal8683139
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6
Regulation of the interleukin-3 (IL-3) receptor by IL-3 in the fetal liver-derived FL5.12 cell line
Autor: P A, Algate, L S, Steelman, M W, Mayo, A, Miyajima, J A, McCubrey
Publikováno v: Blood. 83:2459-2468
To determine the effects of a cytokine on cognate receptor expression in normal and neoplastic cells, the interleukin-3 receptor (IL-3R) complex was examined in the parental IL-3-dependent line FL5.12, which was isolated from fetal liver, and in auto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297e3c5b1efc70158d88a5f9c97dd771
https://doi.org/10.1182/blood.v83.9.2459.bloodjournal8392459
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7
Differential effect of phorbol esters and interleukin-3 on protein kinase C isoform content and kinase activity in the FDC-P1 cell line
Autor: D K, Ways, W, Qin, R S, Riddle, T D, Garris, T E, Bennett, L S, Steelman, J A, McCubrey
Publikováno v: Blood. 78:2633-2641
FD/PMA is a subclone of the interleukin-3 (IL-3)-dependent, FDC-P1 cell line, which proliferates in response to either 12-O- tetradecanoylphorbol-13 acetate (PMA) or IL-3. While several endogenous substrates were phosphorylated in response to protein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd9570ec7ec5d70a627a315a944783b
https://doi.org/10.1182/blood.v78.10.2633.bloodjournal78102633
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8
Chemotherapy for breast cancer
Autor: J. A. McCubrey, R. A. Franklin, P. M. Novolanic, L. S. Steelman, MARTELLI, ALBERTO MARIA
Breast cancer ranks as the second most common cause of cancer death among women in the United States. Only lung cancer, which results primarily from cigarette smoking, induces more cancer deaths in women in the USA. Approximately 1 in 7 women in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4094::f28c3120f017f7c9f5a498f59013aa65
http://hdl.handle.net/11585/67201
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9
Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin
Autor: C R, Weinstein-Oppenheimer, C F, Henríquez-Roldán, J M, Davis, P M, Navolanic, O A, Saleh, L S, Steelman, R A, Franklin, P J, Robinson, M, McMahon, J A, McCubrey
Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(9)
The precise molecular events involved in the development of drug resistance (DR) remain largely unknown. Raf is an intermediate in the signal transduction cascades initiated by growth factors. The hypothesis behind the following studies is that dereg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7542ac6a655df9cdeb822ff4a54280d8
https://pubmed.ncbi.nlm.nih.gov/11555608
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10
Abnormal activation of cytokine gene expression by intracisternal type A particle transposition: effects of mutations that result in autocrine growth stimulation and malignant transformation
Autor: X Y, Wang, L S, Steelman, J A, McCubrey
Publikováno v: Cytokines, cellularmolecular therapy. 3(1)
This review will focus on understanding the mechanisms resulting in the deregulated expression of cytokine genes that can lead to autocrine transformation. The murine genome contains over 2000 copies of intracisternal type A particles (IAPs), which u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::873bcaa733aff7f4c9dd835cb0bf5e9d
https://pubmed.ncbi.nlm.nih.gov/9287239
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