Výsledky vyhledávání - "L S, Ostedgaard"

Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro

Autor: J, Marshall, S, Fang, L S, Ostedgaard, C R, O'Riordan, D, Ferrara, J F, Amara, H, Hoppe, R K, Scheule, M J, Welsh, A E, Smith

Publikováno v: The Journal of biological chemistry. 269(4)

We have generated several clones of Chinese hamster ovary, mouse epitheloid C127, and pig kidney epithelial LLCPK1 cells producing high levels of functional recombinant human cystic fibrosis transmembrane conductance regulator (CFTR). Processing of C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e01f8fb14fa29b89d7eed15e914f615
https://pubmed.ncbi.nlm.nih.gov/7507932

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Dysfunction of CFTR bearing the delta F508 mutation

Autor: M J, Welsh, G M, Denning, L S, Ostedgaard, M P, Anderson

Publikováno v: Journal of cell science. Supplement. 17

The cystic fibrosis transmembrane conductance regulator (CFTR) is mutated in patients with cystic fibrosis (CF). The most common CF-associated mutation is deletion of phenylalanine at residue 508, CFTR delta F508. When expressed in heterologous cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a9bef1c416dd3d2fb857cc53cdf465a
https://pubmed.ncbi.nlm.nih.gov/7511616

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Partial purification of the cystic fibrosis transmembrane conductance regulator

Autor: L S, Ostedgaard, M J, Welsh

Publikováno v: The Journal of biological chemistry. 267(36)

We have investigated several purification strategies for the cystic fibrosis transmembrane regulator (CFTR) based on its structural similarity to other proteins of the traffic ATPase/ABC transporter family. Recombinant CFTR expressed in heterologous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d68a132f214dd4e16ce629d71012b6a
https://pubmed.ncbi.nlm.nih.gov/1281484

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Cyclic AMP-dependent protein kinase activation of cystic fibrosis transmembrane conductance regulator chloride channels in planar lipid bilayers

Autor: B C, Tilly, M C, Winter, L S, Ostedgaard, C, O'Riordan, A E, Smith, M J, Welsh

Publikováno v: The Journal of biological chemistry. 267(14)

Membrane vesicles, prepared from mouse NIH-3T3 fibroblasts and Chinese hamster ovary cells expressing high levels of cystic fibrosis transmembrane conductance regulator (CFTR), were fused with Mueller-Rudin planar lipid bilayers. Upon addition of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bdf95b5f7ba14b27c5f92bc2c0900fdb
https://pubmed.ncbi.nlm.nih.gov/1374403

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