Zobrazeno 1 - 10
of 58
pro vyhledávání: '"L S, Kaminsky"'
Publikováno v:
Carcinogenesis. 19:867-872
The cytochrome P450 (P450) enzymes that catalyse metabolism of the estrogen, estrone (E1), to the putative carcinogen 16alpha-hydroxy E1 (16alpha-OHE1) in humans were determined. The potential of the most abundant circulating form of estrogen, estron
Publikováno v:
Biochemistry. 29:11280-11292
A human liver cytochrome P-450 (P-450) IIIA4 cDNA clone was inserted behind an alcohol dehydrogenase promoter in the plasmid vector pAAH5 and expressed in Saccharomyces cerevisiae (D12 and AH22 strains). A cytochrome P-450 with typical spectral prope
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(7)
Environmental polycyclic aromatic hydrocarbons (PAHs) and metals coexist, and such mixtures could affect the carcinogenicity of PAHs, possibly by modification of PAH induction of the PAH-bioactivating CYP1A. The effect on PAH-mediated CYP1A induction
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(6)
Cytochrome P450 1B1 is a recently recognized phase I bioactivating enzyme with high affinity for both inhaled tobacco carcinogens and 17beta-estradiol. We evaluated the human lung expression of this multifunctional member of the P450 superfamily acro
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(3)
Human small intestine epithelial cells (enterocytes) provide the first site for cytochrome P450 (CYP)-catalyzed metabolism of orally ingested xenobiotics. CYP3A4 is the major form of CYP expressed in enterocytes and CYP2C is also expressed at a signi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(11)
We have recently shown that rat CYP2J4 is inducible by pyrazole in liver, small intestine, and olfactory mucosa. The aim of the present study was to determine whether mouse CYP2Js are also inducible by pyrazole, which was known to induce CYP2A5 in mo
Autor:
L S, Kaminsky, S D, Spivack
Publikováno v:
Molecular aspects of medicine. 20(1-2)
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(10)
Cytochrome P-450 (CYP) 2J4 is a member of the recently identified CYP2J subfamily-part of the CYP superfamily-and is primarily expressed in rat small intestinal epithelium (enterocytes). Studies to determine small intestinal CYP2J4 inducibility by pr
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(7)
Human small intestine epithelial cells (enterocytes) provide the first site for cytochrome P-450 (CYP)-catalyzed metabolism of orally ingested xenobiotics. The CYP composition of enterocytes could thus affect the potential toxicity or therapeutic eff
Publikováno v:
Cancer research. 57(13)
Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed a