Zobrazeno 1 - 10
of 14
pro vyhledávání: '"L S, Higgins"'
Autor:
Peter Fenwick, F Kirschenbaum, Louise E. Donnelly, Mark A. Giembycz, L S Higgins, P. J. Barnes, Andrew G. Nicholson, Susan J. Smith, Tricia Finney-Hayward
Publikováno v:
British Journal of Pharmacology. 149:393-404
Background and purpose: Macrophages release cytokines that may contribute to pulmonary inflammation in conditions such as chronic obstructive pulmonary disease. Thus, inhibition of macrophage cytokine production may have therapeutic benefit. p38 MAPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee97242697f609abf46cf45024b52c8f
https://doi.org/10.1038/sj.bjp.0706885
https://doi.org/10.1038/sj.bjp.0706885
Autor:
I Kerr, L S Higgins, G.F. Schreiner, E Haghnazari, Mamatha M. Reddy, Andrew A. Protter, E G Stebbins, G Luedtke, Satyanarayana Medicherla, G O'Young, J Perumattam, A M Kapoun, J Y Ma, Sarvajit Chakravarty, B Mavunkel, Kenneth C. Anderson, T A Navas, M Henson, Sundeep Dugar, A N Nguyen, Teru Hideshima
Publikováno v:
Leukemia. 20:1017-1027
Inhibition of p38 kinase blocks the production of tumor-promoting factors in the multiple myeloma (MM) bone marrow microenvironment. Proteasome inhibitors MG132 and bortezomib have been shown to have direct cytotoxic effects on MM cells. We show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ea073a76a685a0ade63685d521e9a8
https://doi.org/10.1038/sj.leu.2404200
https://doi.org/10.1038/sj.leu.2404200
Publikováno v:
Journal of Economic Entomology. 92:1014-1020
Oviposition preference by European corn borers, Ostrinia nubilalis (Hubner), for or against transgenic corn would influence amounts of refuge required for resistance management. The objective of this research was to determine if various Bacillus thur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a65534da12214ae027001381b5db9362
https://doi.org/10.1093/jee/92.5.1014
https://doi.org/10.1093/jee/92.5.1014
Publikováno v:
Journal of Biological Chemistry. 269:12179-12184
The 4-kDa beta-amyloid protein that forms fibrillar deposits in Alzheimer's diseased brains is derived from a large precursor, the beta-amyloid precursor protein (beta-APP). Recently, it has been reported that beta-amyloid is normally produced and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87dbc223f40e6660e2f9f3cf29b6093
https://doi.org/10.1016/s0021-9258(17)32698-4
https://doi.org/10.1016/s0021-9258(17)32698-4
Publikováno v:
The American journal of pathology. 149(2)
The presence of beta-amyloid in brain tissue is characteristic of Alzheimer's disease (AD). A naturally occurring derivative of the beta-amyloid peptide, p3, possesses all of the structural determinants required for fibril assembly and neurotoxicity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::283b1c7437ca6f0c71f2fc3edf9f9048
https://pubmed.ncbi.nlm.nih.gov/8701997
https://pubmed.ncbi.nlm.nih.gov/8701997
Publikováno v:
Annals of neurology. 35(5)
Transgenic mice expressing the 751-amino acid form of the human amyloid precursor protein develop extracellular beta-amyloid protein (A beta)-immunoreactive deposits that increase in frequency with age. Here we show that the appearance and histologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdbff79d4730989ba932f10a340cad7
https://pubmed.ncbi.nlm.nih.gov/7513982
https://pubmed.ncbi.nlm.nih.gov/7513982
Publikováno v:
Annals of the New York Academy of Sciences. 695
Mice transgenic for the 751 amino acid isoform of the human beta-amyloid precursor protein (beta-APP) driven by the rat neuron specific enolase (NSE) promoter (NSE:beta-APP751) show features of early Alzheimer's disease (AD) pathology. These features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59dcc14afc317189ac9e9f8be4563cf7
https://pubmed.ncbi.nlm.nih.gov/8239286
https://pubmed.ncbi.nlm.nih.gov/8239286
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 55:650
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b89e9de748ae30ae78376c7601773fa
https://doi.org/10.1097/00005072-199605000-00189
https://doi.org/10.1097/00005072-199605000-00189
Autor:
L S Higgins, Darwin K. Berg
Publikováno v:
The Journal of Cell Biology
Bovine adrenal chromaffin cells have nicotinic acetylcholine receptors (AChRs) that are activated by the splanchnic nerve, resulting in release of catecholamines from the cells. Examination of the AChRs can provide information about the regulation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ce394c3ed4ba245b8124766834081e
http://europepmc.org/articles/PMC2115298
http://europepmc.org/articles/PMC2115298
Autor:
L S Higgins, Darwin K. Berg
Publikováno v:
The Journal of Cell Biology
Bovine adrenal chromaffin cells have nicotinic acetylcholine receptors (AChRs) that mediate release of catecholamines from the cells in response to synaptic input, and resemble neuronal AChRs in pharmacology and antigenic profile. Results presented h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cdd648536ea34bde53a49b43b3281b
https://doi.org/10.1083/jcb.107.3.1157
https://doi.org/10.1083/jcb.107.3.1157