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Ability of activation recovery intervals to assess action potential duration during acute no-flow ischemia in the in situ porcine heart. Experimental Cardiology Group, University of North Carolina at Chapel Hill

Autor: J, Ejima, D, Martin, C, Engle, Z, Sherman, S, Kunimoto, L S, Gettes

Publikováno v: Journal of cardiovascular electrophysiology. 9(8)

The ability to assess transmural changes in action potential duration during acute no-flow ischemia is essential to an understanding of the tachyarrhythmias that occur in this setting. The purpose of this study was to determine if activation recovery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f39ec8b2202e74f44886f55cc51c61c
https://pubmed.ncbi.nlm.nih.gov/9727662

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Comparison of the effects of regional ischemia and hyperkalemia on the membrane action potentials of the in situ pig heart. Experimental Cardiology Group, University of North Carolina at Chapel Hill

Autor: I, Watanabe, A, Kanda, C L, Engle, L S, Gettes

Publikováno v: Journal of cardiovascular electrophysiology. 8(11)

This study was designed to determine the role of increased extracellular potassium [K+]e on action potential duration (APD) in the in situ porcine heart during acute regional no-flow ischemia.In open chest, anesthetized swine, an arterial shunt from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5ced58c5668c757d2eb23e569353417
https://pubmed.ncbi.nlm.nih.gov/9395165

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Correlation of ischemia-induced extracellular and intracellular ion changes to cell-to-cell electrical uncoupling in isolated blood-perfused rabbit hearts. Experimental Working Group

Autor: L M, Owens, T A, Fralix, E, Murphy, W E, Cascio, L S, Gettes

Publikováno v: Circulation. 94(1)

The relationships between the metabolic, ionic, and electrical changes of acute ischemia have not been determined precisely because they have been studied under different experimental conditions. We used ion-selective electrodes, nuclear magnetic res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9fa9893e1f941a68d602cce05b641965
https://pubmed.ncbi.nlm.nih.gov/8964108

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Electrolyte abnormalities underlying lethal and ventricular arrhythmias

Autor: L S, Gettes

Publikováno v: Circulation. 85

It is well known that changes in serum potassium cause ventricular arrhythmias as a result of clearly documented changes in the electrophysiological characteristics of single fibers. Hypopotassemia induced by thiazide and loop diuretics may contribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::939784b8698fedf13bc001d7907d82b4
https://pubmed.ncbi.nlm.nih.gov/1728508

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Effects of ryanodine and BAY K 8644 on membrane properties and conduction during simulated ischemia

Autor: Stephen B. Knisley, J. W. Buchanan, Wayne E. Cascio, Toru Maruyama, L. S. Gettes

Publikováno v: The American journal of physiology. 261(6 Pt 2)

We studied the effect of 1.0 microM ryanodine and 0.1 microM BAY K 8644 (putative modulators of intracellular calcium) on the changes in action potential characteristics, cellular coupling, and longitudinal conduction induced by simulated ischemia (9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052b87ff1cd0376939b1dd8d50d8b91e
https://pubmed.ncbi.nlm.nih.gov/1721501

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Effect of lidocaine and quinidine on steady-state characteristics and recovery kinetics of (dV/dt)max in guinea pig ventricular myocardium

Autor: C M Chen, B G Katzung, L S Gettes

Publikováno v: Circulation Research. 37:20-29

We studied the effects of quinidine and lidocaine on the steady-state relationship between membrane potential and the maximum rate of rise of the action potential, (dV/dt)max, and on the recovery kinetics of (dV/dt)max in guinea pig papillary muscles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0585d97cf07095133996cc37cca19de0
https://doi.org/10.1161/01.res.37.1.20

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Combined effects of rate membrane potential, and drugs on maximum rate of rise (Vmax) of action potential upstroke of guinea pig papillary muscle

Autor: C Chen, L S Gettes

Publikováno v: Circulation Research. 38:464-469

We studied the effect of increasing the rate of stimulation on the maximum rate of rise of the action potential upstroke (Vmax) in guinea pig papillary muscles at various resting membrane potentials and after the addition of quinidine and lidocaine t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb0ba221c27912bc3aac272718435b6
https://doi.org/10.1161/01.res.38.6.464

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A method for measurement of internal longitudinal resistance in papillary muscle

Autor: L. S. Gettes, Shuzo Oshita, J. W. Buchanan, T. Fujino

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 251:H210-H217

We have modified the original Weidmann method for the measurement of internal longitudinal resistance in ventricular muscle by using air rather than silicon oil to insulate guinea pig papillary muscles and by omitting the tetrodotoxin inactivation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497f5bb4224ac9da0b859cf3794b6ef5
https://doi.org/10.1152/ajpheart.1986.251.1.h210

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