Zobrazeno 1 - 10 of 11 pro vyhledávání: '"L S, Banitt"'
1
Bioactivation of 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to Reactive Intermediates That Bind Covalently to Macromolecules and Produce Genotoxicity1
Autor: Schwartz Tm, G L Bundy, K A Koeplinger, J. K. Mayo, G. E. Padbury, Zhiyang Zhao, Harbach Pr, Zimmermann Dc, C.S. Aaron, M J Hauer, L S Banitt
Publikováno v: Chemical Research in Toxicology. 9:1230-1239
U-89843 is a novel pyrrolo[2,3-d]pyrimidine antioxidant with prophylactic activity in animal models of lung inflammation. During preclinical safety evaluation, U-89843 was found to give a positive response in the in vitro unscheduled DNA synthesis (U
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac451d727323d1cb8f441d48692d44a6
https://doi.org/10.1021/tx960092z
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2
Stereoselective synthesis of [11 β-3H]prostaglandin E1
Autor: Gordon L. Bundy, J. A. Easter, Y. Philopoulos, Richard S. P. Hsi, A. J. Wickrema Sinha, L. S. Banitt
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 33:827-838
This report describes an efficient stereoselective synthesis of [11β-3H]prostaglandin E1 ([11β-3H]PGE1). The key multiply protected 11-keto intermediate was prepared in only three steps from PGE1. Reduction of the ketone function at C-11 with sodiu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5778b2c965a5e4901a4ca03908af1505
https://doi.org/10.1002/jlcr.2580330906
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5
Preclinical evaluation of anti-inflammatory activities of the novel pyrrolopyrimidine PNU-142731A, a potential treatment for asthma
Autor: J E, Chin, C A, Hatfield, G E, Winterrowd, R F, Krzesicki, K L, Shull, S F, Fidler, K P, Kolbasa, J R, Brashler, R L, Griffin, W E, Fleming, J M, Justen, L S, Banitt, G L, Bundy, I M, Richards
Publikováno v: The Journal of pharmacology and experimental therapeutics. 290(1)
The anti-inflammatory properties of a novel pyrrolopyrimidine, PNU-142731A, in a murine model of antigen-induced eosinophilic lung inflammation are described. PNU-142731A, when given orally, demonstrated a dose-related inhibition of eosinophil- and l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::513c34a80c0895f815c9f4a616865c11
https://pubmed.ncbi.nlm.nih.gov/10381775
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7
Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity
Autor: Z, Zhao, K A, Koeplinger, G E, Padbury, M J, Hauer, G L, Bundy, L S, Banitt, T M, Schwartz, D C, Zimmermann, P R, Harbach, J K, Mayo, C S, Aaron
Publikováno v: Chemical research in toxicology. 9(8)
U-89843 is a novel pyrrolo[2,3-d]pyrimidine antioxidant with prophylactic activity in animal models of lung inflammation. During preclinical safety evaluation, U-89843 was found to give a positive response in the in vitro unscheduled DNA synthesis (U
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b0d73d329f6bb628483afbc4c0cecfb
https://pubmed.ncbi.nlm.nih.gov/8951224
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8
In vitro and in vivo biotransformation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-D]pyrimidine (U-89843) in the rat
Autor: Z, Zhao, K A, Koeplinger, G L, Bundy, L S, Banitt, G E, Padbury, M J, Hauer, P E, Sanders
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 24(2)
The biotransformation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) has been studied in rat both in vitro and in vivo. Major metabolites observed by HPLC analysis of rat plasma, liver cytosol, and microsomal incubations
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa8bc43ffa41a75f97e829d937ee7089
https://pubmed.ncbi.nlm.nih.gov/8742230
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9
Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants
Autor: E D, Hall, P K, Andrus, S L, Smith, J A, Oostveen, H M, Scherch, B S, Lutzke, T J, Raub, G A, Sawada, J R, Palmer, L S, Banitt, J S, Tustin, K L, Belonga, D E, Ayer, G L, Bundy
Publikováno v: Acta neurochirurgica. Supplement. 66
The 21-aminosteroid (lazaroid) tirilazad mesylate has been demonstrated to be a potent inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of experimental models. Currently, tirilazad is being actively investigated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef2a22bfa5202feee4c71d54b7000ffa
https://pubmed.ncbi.nlm.nih.gov/8780807
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10
Neuroprotective Efficacy of Microvascularly-Localized Versus Brain-Penetrating Antioxidants
Autor: Gordon L. Bundy, Geri A. Sawada, Paula K. Andrus, Sarah L. Smith, J. S. Tustin, John R. Palmer, Edward D. Hall, Donald E. Ayer, Thomas J. Raub, Barry S. Lutzke, Jo A. Oostveen, Heidi M. Scherch, K. L. Belonga, L. S. Banitt
Publikováno v: Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma ISBN: 9783709194676
The 21-aminosteroid (lazaroid) tirilazad mesylate has been demonstrated to be a potent inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of experimental models. Currently, tirilazad is being actively investigated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8124d77933406848f8de36a79d00aa7
https://doi.org/10.1007/978-3-7091-9465-2_19
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