Zobrazeno 1 - 10
of 27
pro vyhledávání: '"L Ravithej, Singh"'
Autor:
Julalak Chuprom, Suthinee Sangkanu, Watcharapong Mitsuwan, Rachasak Boonhok, Wilawan Mahabusarakam, L. Ravithej Singh, Ekachai Dumkliang, Kritamorn Jitrangsri, Alok K. Paul, Sirirat Surinkaew, Polrat Wilairatana, Maria de Lourdes Pereira, Mohammed Rahmatullah, Christophe Wiart, Sonia Marlene Rodrigues Oliveira, Veeranoot Nissapatorn
Publikováno v:
PeerJ, Vol 10, p e14468 (2022)
Garcinia mangostana L., also known as the mangosteen tree, is a native medicinal plant in Southeast Asia having a wide variety of pharmacologically active compounds, including xanthonoid mangostin. In this study, we examined the pharmacological activ
Externí odkaz:
https://doaj.org/article/6bb3c5acd55b4c168135e1400b8ba43a
Autor:
L. Ravithej Singh, Yu-Lin Chen, Yuan-Yuan Xie, Wei Xia, Xing-Wen Gong, Robert C. Hider, Tao Zhou
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1562-1567 (2020)
In an attempt to synthesise new tyrosinase inhibitors, we designed and synthesised a series of chalcone-hydroxypyridinone hybrids as potential tyrosinase inhibitors adopting strategic modifications of kojic acid. All the newly synthesised compounds w
Externí odkaz:
https://doaj.org/article/1f54c5fec4ba449f9607c6974b604ecb
Autor:
Dipak Datta, Koneni V. Sashidhara, Jiaur R. Gayen, Mohammad I. Siddiqi, Himangsu K. Bora, Mohammed Riyazuddin, Ruchir Kant, Anup K. Singh, Sanjeev Meena, Tanuj Sharma, Sudhir Shahi, Srikanth H. Cheruvu, Rakesh K. Arya, Gopala R. Palnati, L. Ravithej Singh, Akhilesh Singh, Srinivasa R. Avula, Shrankhla Maheshwari
SUPPLEMENTARY FIGURE S1: General information and rationale of synthesis of hybrid molecules of Chalcone and Semicarbazone SUPPLEMENTARY FIGURE S2: Detailed qualitative analysis of compounds of Chalcone and Semicarbazone hybrid series Supplementary Fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628b9cafc6e1657c72659a9162691b6b
https://doi.org/10.1158/1535-7163.22508397.v1
https://doi.org/10.1158/1535-7163.22508397.v1
Autor:
Julalak, Chuprom, Suthinee, Sangkanu, Watcharapong, Mitsuwan, Rachasak, Boonhok, Wilawan, Mahabusarakam, L Ravithej, Singh, Ekachai, Dumkliang, Kritamorn, Jitrangsri, Alok K, Paul, Sirirat, Surinkaew, Polrat, Wilairatana, Maria de Lourdes, Pereira, Mohammed, Rahmatullah, Christophe, Wiart, Sonia Marlene Rodrigues, Oliveira, Veeranoot, Nissapatorn
Publikováno v:
PeerJ. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c74cacfa7541e34b9eddc157dd872d5
https://pubmed.ncbi.nlm.nih.gov/36523474
https://pubmed.ncbi.nlm.nih.gov/36523474
Publikováno v:
Bioorganicmedicinal chemistry. 41
Respiratory infections resulting from pulmonary inflammation emerging as a leading cause of death worldwide. However, only twenty-seven new drugs were approved in the last five decades. In this review, we presented synthetic approaches for twenty-sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5af200b4364c88980577af75eaef24c
https://pubmed.ncbi.nlm.nih.gov/34000507
https://pubmed.ncbi.nlm.nih.gov/34000507
Autor:
Mohammad Imran Siddiqi, Srikanth H. Cheruvu, Akhilesh Kumar Singh, Mohammed Riyazuddin, L. Ravithej Singh, Shrankhla Maheshwari, Himangsu K. Bora, Koneni V. Sashidhara, Rakesh K. Arya, Sanjeev Meena, Anup Kumar Singh, Dipak Datta, Ruchir Kant, Gopala R. Palnati, Srinivasa Rao Avula, Sudhir Shahi, Jiaur R. Gayen, Tanuj Sharma
Publikováno v:
Molecular Cancer Therapeutics. 16:1791-1805
Molecular hybridization of different pharmacophores to tackle both tumor growth and metastasis by a single molecular entity can be very effective and unique if the hybrid product shows drug-like properties. Here, we report synthesis and discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9852b24932074eb922b79e707fd075b
https://doi.org/10.1158/1535-7163.mct-16-0584
https://doi.org/10.1158/1535-7163.mct-16-0584
Autor:
Koneni V. Sashidhara, Shubham Pandey, L. Ravithej Singh, Sampa Gupta, Amit K. Rai, Akhilesh K. Tamrakar, Ruchir Kant
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 34:127760
The design and synthesis of a series of pyrazolo[3,4-d]pyrimidinones containing fibrate side chains have been accomplished by utilizing the concept of molecular hybridization. All the synthesized compounds were evaluated for the glucose uptake stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9d8a440e2c62c718299476f437a543
https://doi.org/10.1016/j.bmcl.2020.127760
https://doi.org/10.1016/j.bmcl.2020.127760
Autor:
L. Ravithej Singh, Koneni V. Sashidhara, Ruchir Kant, Srinivasa Rao Avula, Gopala Reddy Palnati
Publikováno v:
Synlett. 27:2384-2390
An operationally simple, one-pot, catalyst-free method was developed for the synthesis of pharmaceutically important substituted isoindolinones by a three-component reaction of 2-formylbenzoic acid, a primary amine, and a 1,3-dione in ethanol under d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee538b516184045a340a4918f673c43
https://doi.org/10.1055/s-0035-1562614
https://doi.org/10.1055/s-0035-1562614
Autor:
Akanksha Upadhyay, Vikash Chandra Tripathi, Sneha Raj, L. Ravithej Singh, Anoop Kumar, Koneni V. Sashidhara, Mukesh Pasupuleti, Jesu Arockiaraj, Pragati Kushwaha, Soyar Horam, Sampa Gupta
Publikováno v:
Drug development research. 79(8)
Hit, Lead & Candidate Discovery Drug repurposing has become a recent trend in drug development programs, where previously developed drugs are explored for hit and redeveloped into potential therapeutic agents for new diseases. Globally, in any drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cf5db6b7a3abf39d25b6fe2e0e59cc
https://pubmed.ncbi.nlm.nih.gov/30291767
https://pubmed.ncbi.nlm.nih.gov/30291767
Autor:
L. Ravithej Singh, Koneni V. Sashidhara, Akanksha Upadhyay, Gopala Reddy Palanati, Kamakshi Sikka, Mohammad Imran Siddiqi, Ajeet Kumar, Sampa Gupta, Prem N. Yadav
Publikováno v:
European journal of medicinal chemistry. 152
In this study, we presented rational designing and synthesis of coumarin-dihydroquinazolinone conjugates to evaluate their agonist activity at GPR109a receptor. Among the synthesized small molecule library, compound 10c displayed robust agonist actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dddafca3f5bc3cab6ad9205430c754d
https://pubmed.ncbi.nlm.nih.gov/29709786
https://pubmed.ncbi.nlm.nih.gov/29709786