Zobrazeno 1 - 10
of 12
pro vyhledávání: '"L Rainer Butler"'
Publikováno v:
eLife, Vol 9 (2020)
Vector-borne illnesses comprise a significant portion of human maladies, representing 17% of global infections. Transmission of vector-borne pathogens to mammals primarily occurs by hematophagous arthropods. It is speculated that blood may provide a
Externí odkaz:
https://doaj.org/article/a7f1e591b75d41eb9337f90812d3beec
Autor:
Agustin Rolandelli, Hanna J. Laukaitis-Yousey, Haikel N. Bogale, Nisha Singh, Sourabh Samaddar, Anya J. O’Neal, Camila R. Ferraz, Matthew Butnaru, Enzo Mameli, Baolong Xia, M. Tays Mendes, L. Rainer Butler, Liron Marnin, Francy E. Cabrera Paz, Luisa M. Valencia, Vipin S. Rana, Ciaran Skerry, Utpal Pal, Stephanie E. Mohr, Norbert Perrimon, David Serre, Joao H. F. Pedra
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Uncovering the complexity of systems in non-model organisms is critical for understanding arthropod immunology. Prior efforts have mostly focused on Dipteran insects, which only account for a subset of existing arthropod species in nature. H
Externí odkaz:
https://doaj.org/article/b8408903b74947ab809bab3b8951c302
Autor:
L. Rainer Butler, Nisha Singh, Liron Marnin, Luisa M. Valencia, Anya J. O’Neal, Francy E. Cabrera Paz, Dana K. Shaw, Adela S. Oliva Chavez, Joao H. F. Pedra
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Background The blacklegged tick, Ixodes scapularis, transmits most vector-borne diseases in the US. It vectors seven pathogens of public health relevance, including the emerging human pathogen Anaplasma phagocytophilum. Nevertheless, it rema
Externí odkaz:
https://doaj.org/article/05e56b34e7ea41e7b9fa76b671ae63b2
Autor:
Nisha Singh, Agustin Rolandelli, Anya J. O’Neal, L. Rainer Butler, Sourabh Samaddar, Hanna J. Laukaitis-Yousey, Matthew Butnaru, Stephanie E. Mohr, Norbert Perrimon, Joao H. F. Pedra
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Although genetic manipulation is one of the hallmarks of model organisms, its applicability to non-model species has remained difficult due to our limited understanding of their fundamental biology. For instance, manipulation of a cell line
Externí odkaz:
https://doaj.org/article/c24046a9f6c5472ebc9808c2928d789f
Autor:
Adela S. Oliva Chávez, Xiaowei Wang, Liron Marnin, Nathan K. Archer, Holly L. Hammond, Erin E. McClure Carroll, Dana K. Shaw, Brenden G. Tully, Amanda D. Buskirk, Shelby L. Ford, L. Rainer Butler, Preeti Shahi, Kateryna Morozova, Cristina C. Clement, Lauren Lawres, Anya J. O’ Neal, Choukri Ben Mamoun, Kathleen L. Mason, Brandi E. Hobbs, Glen A. Scoles, Eileen M. Barry, Daniel E. Sonenshine, Utpal Pal, Jesus G. Valenzuela, Marcelo B. Sztein, Marcela F. Pasetti, Michael L. Levin, Michail Kotsyfakis, Steven M. Jay, Jason F. Huntley, Lloyd S. Miller, Laura Santambrogio, Joao H. F. Pedra
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Extracellular vesicles have been implicated in the transmission of pathogens from the arthropod to the human host. Here the authors show that tick-derived extracellular vesicles play a role in feeding and modulate the outcome of bacterial infection.
Externí odkaz:
https://doaj.org/article/41e1c07d29b74e5f972379e9fa87802a
Autor:
Sourabh Samaddar, Anya J O'Neal, Liron Marnin, Agustin Rolandelli, Nisha Singh, Xiaowei Wang, L. Rainer Butler, Parisa Rangghran, Hanna J Laukaitis, Francy E Cabrera Paz, Gary M Fiskum, Brian M Polster, Joao HF Pedra
Publikováno v:
bioRxiv
Arthropod-borne microbes rely on the metabolic state of a host to cycle between evolutionarily distant species. For instance, arthropod tolerance to infection may be due to redistribution of metabolic resources, often leading to microbial transmissio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dadefc7989a13d65b3ac4e6e59c20d7
https://doi.org/10.1101/2023.05.26.542501
https://doi.org/10.1101/2023.05.26.542501
Autor:
Anya J. O’Neal, Nisha Singh, Agustin Rolandelli, Hanna J. Laukaitis, Xiaowei Wang, Dana K. Shaw, Brianna D. Young, Sukanya Narasimhan, Shraboni Dutta, Greg A. Snyder, Sourabh Samaddar, Liron Marnin, L. Rainer Butler, M. Tays Mendes, Francy E. Cabrera Paz, Luisa M. Valencia, Eric J. Sundberg, Erol Fikrig, Utpal Pal, David J. Weber, Joao H. F. Pedra
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e058ce38e5f57725218a3f90eac7492
https://doi.org/10.1073/pnas.2208673120
https://doi.org/10.1073/pnas.2208673120
Publikováno v:
Trends Parasitol
Metabolism influences biochemical networks, and arthropod vectors are endowed with an immune system that affects microbial acquisition, persistence, and transmission to humans and other animals. Here, we aim to persuade the scientific community to ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0aa81ef8687fdbbc4a1076d0244454c
https://doi.org/10.1016/j.pt.2020.07.010
https://doi.org/10.1016/j.pt.2020.07.010
Autor:
Anya J. O’Neal, Nisha Singh, Iain S. Forrest, Agustin Rolandelli, Xiaowei Wang, Dana K. Shaw, Brianna D. Young, Sukanya Narasimhan, Shraboni Dutta, Greg A. Snyder, Liron Marnin, L. Rainer Butler, Sourabh Samaddar, M. Tays Mendes, Francy E. Cabrera Paz, Luisa M. Valencia, Eric J. Sundberg, Erol Fikrig, Utpal Pal, David J. Weber, Ron Do, Joao H.F. Pedra
Pattern recognition receptors sense pathogens in arthropods and mammals through distinct immune processes. Whether these molecules share a similar function and recognize the same microbe in evolutionarily distant species remain ill-defined. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e6eb886d24d545b1a5b7d0315a261a6
https://doi.org/10.1101/2022.02.09.479763
https://doi.org/10.1101/2022.02.09.479763
Autor:
Jason F. Huntley, Lloyd S. Miller, Preeti Shahi, Michail Kotsyfakis, Adela S. Oliva Chávez, Eileen M. Barry, Laura Santambrogio, Daniel E. Sonenshine, Choukri Ben Mamoun, Holly L. Hammond, Steven M. Jay, Shelby L Ford, L. Rainer Butler, Kateryna Morozova, Utpal Pal, Brandi E. Hobbs, Dana K. Shaw, Glen A. Scoles, Joao H. F. Pedra, Xiaowei Wang, Amanda D. Buskirk, Cristina C. Clement, Brenden G. Tully, Jesus G. Valenzuela, Liron Marnin, Nathan K. Archer, Michael Levin, Anya J.O’ Neal, Marcela F. Pasetti, Erin E.Mc Clure Carroll, Kathleen L. Mason, Marcelo B. Sztein, Lauren Lawres
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc0d5dbf8bf7bde03f649651aa591e9
https://doi.org/10.1038/s41467-021-23900-8
https://doi.org/10.1038/s41467-021-23900-8