Zobrazeno 1 - 10
of 17
pro vyhledávání: '"L R Tranquill"'
Autor:
Ligong Cao, L. R. Tranquill, Hubert Kalbacher, Roland M Martin, John N. Whitaker, Nicholas Ling
Publikováno v:
Multiple Sclerosis Journal. 6:220-225
Myelin basic protein (MBP), a candidate autoantigen in multiple sclerosis (MS), exists in different isoforms and charge isomers generated by differential splicing of exons and by a combination of posttranslational modifications, respectively. These v
Publikováno v:
Journal of Neuroimmunology. 89:198-205
Cytokines are produced by numerous cell types in the peripheral blood and central nervous system (CNS), and have been implicated in the immunopathogenesis of multiple sclerosis (MS). We examined the relationship between cytokine gene expression of ce
Publikováno v:
Neurology. 49:1111-1116
Adhesion molecules are likely to play a critical role in the immunopathogenesis of multiple sclerosis (MS). The interaction of vascular cell adhesion molecule-1 (VCAM-1) with its lymphocyte ligand very late antigen-4 (VLA-4) may mediate migration of
Autor:
S.C Rojo, Hermann Beck, M. Kalbus, L. R. Tranquill, B. Hemmer, R De Mars, Henry F. McFarland, Hubert Kalbacher, Eric O. Long, Marco Vergelli, Roland Martin
Publikováno v:
Journal of Neuroimmunology. 77:195-203
In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple
Autor:
James M. Dambrosia, H. Maloni, Henry F. McFarland, L. R. Tranquill, Lael Stone, C. N. Bash, P. A. Calabresi, Joseph A. Frank
Publikováno v:
Annals of Neurology. 41:669-674
Interferon beta-1b reduces clinical exacerbations and disease activity in multiple sclerosis as shown by magnetic resonance imaging, but the mechanism of action is unknown. We investigated the correlation between the levels of soluble adhesion molecu
Autor:
Edwina Skinner, Rhonda R. Voskuhl, Bernhard Hemmer, Anthony T. Campagnoni, Paolo A. Muraro, Celia W. Campagnoni, L. R. Tranquill, Roland Martin, Henry F. McFarland, M. Vengelli
Publikováno v:
Journal of Neuroscience Research. 45:820-828
Myelin basic protein (MBP) is a candidate auto-antigen in the disease multiple sclerosis. Although MBP was thought to be sequestered behind the blood-brain barrier, isoforms of MBPs have recently been demonstrated in lymphoid tissues. These isoforms,
Publikováno v:
Multiple Sclerosis Journal. 1:270-278
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system in which autoimmune T lymphocytes reacting with myelin antigens are believed to play a pathogenic role. Since HLA binding is involved in the selection of T cell response
Publikováno v:
The Journal of Immunology. 154:6191-6202
Several stimuli induce mature T cells to undergo apoptosis or programmed cell death (PCD) including specific Ag. We have demonstrated previously that Ag induces the death of encephalitogenic T cells in vitro and deletion in vivo, leading to ameliorat
Autor:
H. Maloni, L. R. Tranquill, Rhonda R. Voskuhl, Dale E. McFarlin, Gladys E. Deibler, Henry F. McFarland, Roger D. Stone
Publikováno v:
Journal of Neuroimmunology
Although the major isoform of myelin basic protein (MBP) in the healthy adult CNS is the 18.5-kDa protein, other isoforms containing exon 2 encoded protein (21.5 kDa and 20.2 kDa) exist and are expressed primarily during myelin formation. Since remye
Autor:
Bruno Gran, M. Chen, Roland Martin, W. Zhou, Suhayl Dhib-Jalbut, L. R. Tranquill, Bibiana Bielekova
Publikováno v:
Neurology. 55(11)
Objective: To define the mechanism of action of glatiramer acetate (GA; formerly known as copolymer-1) as an immunomodulatory treatment for MS. Background: The proposed mechanisms of action of GA include 1) functional inhibition of myelin-reactive T