Zobrazeno 1 - 10
of 48
pro vyhledávání: '"L R Pease"'
Autor:
M D Tallquist, L R Pease
Publikováno v:
The Journal of Immunology. 155:2419-2426
Previous studies hav shown that 2C T cells have dual specificity for Ld and Kbm3 alloantigens and are positively selected in the context of Kb. Analysis of Kbm3-eluted peptides reveals a single HPLC fraction that is a central component of the Kbm3 al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e2443eeb8e4b7deb0b7e4a8a1696cb0
https://doi.org/10.4049/jimmunol.155.5.2419
https://doi.org/10.4049/jimmunol.155.5.2419
Autor:
A N Vallejo, L R Pease
Publikováno v:
The Journal of Immunology. 154:3912-3921
The expansion and contraction of mammalian class I multigene families raises the issue as to what determines the loss or retention of family members. We propose that accumulating changes in regulatory regions result in the loss of expression of the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b01214b4c43e178d9a12b36790c15d7
https://doi.org/10.4049/jimmunol.154.8.3912
https://doi.org/10.4049/jimmunol.154.8.3912
Publikováno v:
The Journal of Immunology. 152:5337-5343
Activation of a T cell in response to peptide bound to class I MHC occurs by the sum of interactions across the area of contact between the TCR, the peptide, and class I MHC. It has been observed recently that substitution of the peptide residue at a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97eb370f0644b7738f483fa17f106f13
https://doi.org/10.4049/jimmunol.152.11.5337
https://doi.org/10.4049/jimmunol.152.11.5337
Autor:
L R Pease, R M Horton, J K Pullen, H D Hunt, T J Yun, E M Rohren, J L Prescott, S M Jobe, K S Allen
Publikováno v:
The Journal of Immunology. 150:3375-3381
Structural changes on the surface of the class I Ag binding domain resulting from point mutations localized inside the Ag binding cleft of the H-2Kb and Kf glycoproteins were revealed using mAb. Both the loss and gain of antibody binding sites found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a16d0015bdfcee99f27adb2b3dd62c1
https://doi.org/10.4049/jimmunol.150.8.3375
https://doi.org/10.4049/jimmunol.150.8.3375
Publikováno v:
The Journal of Immunology. 148:921-927
Intracerebral infection of certain strains of mice with Theiler's virus results in chronic immune-mediated demyelination in spinal cord. We used mouse mutants with deletion of the V beta class of TCR genes to examine the role of TCR genes in this dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a7a72f09bc0fb2cc57cb4dbf805ff4
https://doi.org/10.4049/jimmunol.148.3.921
https://doi.org/10.4049/jimmunol.148.3.921
Publikováno v:
The Journal of Immunology. 148:953-967
Twenty-three class I DNA sequences, representing alleles of the H-2K, D, and L loci, were analyzed to assess patterns of nucleotide and amino acid diversity. Comparisons of the allelic and nonallelic sequences revealed locus specificity in regions en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be137e486bac575ce313edb804f965f1
https://doi.org/10.4049/jimmunol.148.3.953
https://doi.org/10.4049/jimmunol.148.3.953
Publikováno v:
The Journal of Immunology. 147:3180-3184
A spontaneous mutation of H-2Kb, Kbm29, was discovered among the progeny of F1 hybrid parents. Unlike other characterized spontaneous class I variants, this mutant was detected with the use of antibody, rather than tissue grafting. Although Kbm29 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aabd511b6b6db8102e8eca59ea15b255
https://doi.org/10.4049/jimmunol.147.9.3180
https://doi.org/10.4049/jimmunol.147.9.3180
Publikováno v:
The Journal of Immunology. 146:2145-2151
The ability of OVA-specific H-2Kb-restricted CTL to recognize the defined OVA258-276 peptide in the context of the Kbm mutants and variants of these mutants was examined to determine how specific variations in the Ag recognition site-influenced pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50d67ad5774d93c30f9bcf024697741
https://doi.org/10.4049/jimmunol.146.7.2145
https://doi.org/10.4049/jimmunol.146.7.2145
Publikováno v:
The Journal of Immunology. 145:1782-1787
The H-2Kf allele and the spontaneous mutant Kfm1 have been cloned using locus-specific sequences. The mutation consists of a cluster of four nucleotide changes, resulting in amino acid substitutions at positions 95 (Leu----Ile) and 97 (Val----Arg). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::182cb231e20733494722ccaa34218514
https://doi.org/10.4049/jimmunol.145.6.1782
https://doi.org/10.4049/jimmunol.145.6.1782
Publikováno v:
The Journal of Immunology. 145:1456-1462
We have analyzed the functional significance of the four amino acid differences between the parental H-2Kb and mutant H-2Kbm8 glycoproteins. Six bm8 variants including single substitutions at residues 22, 23, 24, and 30 as well as paired substitution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f34c5889dc22054b86632f2fde9509b
https://doi.org/10.4049/jimmunol.145.5.1456
https://doi.org/10.4049/jimmunol.145.5.1456