Zobrazeno 1 - 10
of 20
pro vyhledávání: '"L R Boone"'
Autor:
G S Lowell, John Milton, David I. Stuart, Joseph H. Chan, George Andrew Freeman, S S Gonzales, Steven A. Short, Jingshan Ren, Andrew L. Hopkins, K L Creech, Richard J. Hazen, R G Ferris, G W Koszalka, L T Schaller, G B Roberts, Cowan, C W Andrews Iii, Kurt Weaver, L R Boone, David K. Stammers, D J Reynolds
HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba0381a0617d10120e121697f22e025
https://doi.org/10.1021/jm040072r
https://doi.org/10.1021/jm040072r
Autor:
Kurt Weaver, Jingshan Ren, L R Boone, R G Ferris, A Freeman, Steven A. Short, Anna Stamp, Richard J. Hazen, K.R Romines, C W Andrews Iii, P.P. Chamberlain, David K. Stammers, Joseph H. Chan
Publikováno v:
Journal of Medicinal Chemistry. 51:5000-5008
Owing to the emergence of resistant virus, next generation non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) with improved drug resistance profiles have been developed to treat HIV infection. Crystal structures of HIV-1 RT complexed with b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832c8ffe10f26487effda5730a48ae45
https://doi.org/10.1021/jm8004493
https://doi.org/10.1021/jm8004493
Autor:
M. J. Waring, Scott R. Stetor, J. W. Rausch, M.-J. Guo, S. F. J. Le Grice, L. R. Boone, J. P. Burnham
Publikováno v:
Biochemistry. 38:3656-3667
Permeabilized preparations of equine infectious anemia virus (EIAV) are shown here to support efficient and accurate synthesis of full-length double-stranded proviral DNA. When (-) and (+) strand products were analyzed by Southern blotting, a discont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289f4eba89539b34b69fab6ae4518ae5
https://doi.org/10.1021/bi982764l
https://doi.org/10.1021/bi982764l
Autor:
R J Ott, Kurt Weaver, David K. Stammers, G F Orr, Joseph H. Chan, Andrew L. Hopkins, Douglas B. Sherman, Steven A. Short, R G Ferris, S M Sparks, M St Clair, David I. Stuart, C W Andrews Iii, Robert N. Hunter, B E Reitter, J S Hong, K L Creech, G B Roberts, Cowan, L R Boone, Jingshan Ren, Richard J. Hazen
Publikováno v:
Journal of medicinal chemistry. 44(12)
A series of 2-amino-5-arylthiobenzonitriles (1) was found to be active against HIV-1. Structural modifications led to the sulfoxides (2) and sulfones (3). The sulfoxides generally showed antiviral activity against HIV-1 similar to that of 1. The sulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bc1966b43139f9d26bc16962ee2c49
https://pubmed.ncbi.nlm.nih.gov/11384233
https://pubmed.ncbi.nlm.nih.gov/11384233
Autor:
L, Ross, M, Johnson, R G, Ferris, S A, Short, L R, Boone, T E, Melby, R, Lanier, M, Shaefer, M, St Clair
Publikováno v:
Journal of human virology. 3(3)
To examine the effect of in-frame deletions in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on plasma viremia and phenotypic resistance to antiretroviral drugs.Plasma HIV-1 RNA was isolated from 168 antiretroviral therapy-ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4a818528cce1e31af6146c7bc1aaaf7
https://pubmed.ncbi.nlm.nih.gov/10881994
https://pubmed.ncbi.nlm.nih.gov/10881994
Autor:
H.C. Krasny, R E Dornsife, L R Boone, I Najera, R J Hazen, M Tisdale, Vasu Nair, M H St Clair, J E Reardon, M T Paff
Publikováno v:
Antimicrobial agents and chemotherapy. 39(9)
4(S)-(6-Amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol(IsoddA)isthemostantivirallyactivemember of a novel class of optically active isomeric dideoxynucleosides in which the base has been transposed from the natural 1*position to the 2*position and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a839a8c8cd78961445e9bf7c0a8dcd
https://pubmed.ncbi.nlm.nih.gov/8540705
https://pubmed.ncbi.nlm.nih.gov/8540705
Autor:
K Borroto-Esoda, L R Boone
Publikováno v:
Journal of virology. 65(4)
The endogenous reverse transcriptase reaction of equine infectious anemia virus (EIAV) has been studied, and conditions allowing synthesis of full-length minus-strand DNA have been determined. In contrast to results reported for other retroviruses, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42caaab920f35510ab86a8cbbcd6cf3e
https://pubmed.ncbi.nlm.nih.gov/1705993
https://pubmed.ncbi.nlm.nih.gov/1705993
Autor:
Wen-Kuang Yang, C. K. Koh, D. M. Yang, L. R. Boone, F. E. Myer, Raymond W. Tennant, C. Y. Ou, L. E. Roberson
Publikováno v:
Journal of Virology. 48:110-119
We molecularly cloned unintegrated viral DNA of the BALB/c endogenous N-tropic and B-tropic murine leukemia retroviruses and in vitro passaged N-tropic Gross (passage A) murine leukemia retroviruses. Recombinant genomes were constructed in vitro by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b2cb6d94d86aa894efd613842fe7c2
https://doi.org/10.1128/jvi.48.1.110-119.1983
https://doi.org/10.1128/jvi.48.1.110-119.1983
Autor:
Wen-Kuang Yang, J. O. Kiggans, D. M. Yang, R. S. Liou, Raymond W. Tennant, L. R. Boone, T. W. Wang
Publikováno v:
Journal of Virology. 46:288-292
We molecularly cloned and analyzed an N-tropic ecotropic retrovirus induced with iododeoxyuridine from RFM/Un mouse cell cultures. Based on the restriction map, the RFM/Un virus appears to be indistinguishable from other induced N-tropic retroviruses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e5a4bf7a7a4791c406fb750c0c00cf
https://doi.org/10.1128/jvi.46.1.288-292.1983
https://doi.org/10.1128/jvi.46.1.288-292.1983
Autor:
A M Skalka, L R Boone
Publikováno v:
Journal of Virology. 37:109-116
We have examined the kinetics of synthesis of minus [(-)]- and plus [(+)]-strand viral DNA in melittin-permeabilized avian retrovirus particles. The reaction was biphasic. There was a very rapid initial rate, followed, after approximately 1 h, by a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdc629fe82c971e19125c23f04e2db6
https://doi.org/10.1128/jvi.37.1.109-116.1981
https://doi.org/10.1128/jvi.37.1.109-116.1981