Zobrazeno 1 - 10
of 49
pro vyhledávání: '"L R, Kelland"'
Autor:
L. R Kelland
Publikováno v:
AACR Education book. 2008:209-213
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::252de6e714aa8fe24428c11f1303ab7c
https://doi.org/10.1158/aacr.edb-08-8077
https://doi.org/10.1158/aacr.edb-08-8077
Publikováno v:
Journal of Medicinal Chemistry. 43:3189-3192
The synthesis of two new isomeric trifunctional dinuclear platinum complexes of formula [¿PtCl(NH(3))(2)¿micro-NH(2)(CH(2))(6)NH(2)-¿PtCl(2)(N H(3))¿](+) (1, 2/c,c and 1,2/t,c) is reported. Their biological activity in selected human tumor cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9273a55742fc1f25a5556e74ea4b5fb7
https://doi.org/10.1021/jm990536z
https://doi.org/10.1021/jm990536z
Publikováno v:
British Journal of Cancer
The cellular pharmacology of a series of C8-linked pyrrolobenzodiazepine dimers with polymethylene linkers of n = 3-6 (compounds 1-4) has been studied in a range of human tumour cell lines. The four compounds showed the same pattern of relative activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0a9efd7e5843dd5ec88ea7949b7189
https://doi.org/10.1038/bjc.1994.248
https://doi.org/10.1038/bjc.1994.248
Autor:
L R, Kelland, P J, Beale
Publikováno v:
Methods in molecular medicine. 28
In recent years, immunohistochemistry as applied to the Bcl-2 family of proteins has represented a burgeoning area of interest to cancer researchers. The majority of studies have focused on the original member Bcl-2, first identified via its involvem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::122368e372430c01609f2282e656f740
https://pubmed.ncbi.nlm.nih.gov/21374039
https://pubmed.ncbi.nlm.nih.gov/21374039
Publikováno v:
British Journal of Cancer
Enhanced repair of DNA adducts may be a cause of cis-diamminedichloroplatinum(II) resistance in solid malignancies. Binding of specific damage recognition proteins to the sites of DNA damage may be involved in the initial steps of DNA repair, or alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c9954809e0ca390e9aaee74f537f7a
https://doi.org/10.1038/bjc.1993.135
https://doi.org/10.1038/bjc.1993.135
Autor:
L R, Kelland
Publikováno v:
IDrugs : the investigational drugs journal. 2(6)
Currently there is an intensive drug discovery effort aimed at introducing more selective cancer drugs into the clinic which exploit various targets emerging from the increasing molecular understanding of the disease. Examples include inhibitors of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33d478ebd5df131b999fa965f63381c8
https://pubmed.ncbi.nlm.nih.gov/16127615
https://pubmed.ncbi.nlm.nih.gov/16127615
Autor:
A, Varvaresou, K, Iakovou, E, Gikas, I, Fichtner, H H, Fiebig, L R, Kelland, J A, Double, M C, Bibby, H R, Hendriks
Publikováno v:
Anticancer research. 24(2B)
A new series of imidazothioxanthones has recently been synthesized as potential anticancer agents with the aim of overcoming drug resistance. The route of synthesis and DNA-binding properties of the compounds were reported previously. This paper desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58a5f6d0b710ebdb8966a1267885541b
https://pubmed.ncbi.nlm.nih.gov/15161044
https://pubmed.ncbi.nlm.nih.gov/15161044
Autor:
L R, Kelland
Publikováno v:
European journal of cancer (Oxford, England : 1990). 40(6)
Human tumour xenografts implanted subcutaneously (s.c.) into immunosuppressed mice have played a significant role in preclinical anticancer drug development for the past 25 years. Their use as a predictive indicator of probable clinical activity has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9dcb6470c0de31b9c78597caad85c769
https://pubmed.ncbi.nlm.nih.gov/15120038
https://pubmed.ncbi.nlm.nih.gov/15120038
Publikováno v:
Anti-cancer drug design. 16(1)
N-Acetyl-4-S-cysteaminylphenol 1 is an analogue of a biosynthetic intermediate in the pathway to melanin. It is probably oxidized to an o-quinone which can alkylate cellular nucleophiles resulting in interference with cell growth and proliferation. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e25867cda9db3f685e5cf2eb24d153bc
https://pubmed.ncbi.nlm.nih.gov/11762644
https://pubmed.ncbi.nlm.nih.gov/11762644
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(10)
We have established preclinical models for the development of drug resistance to vincristine (a major drug used in the treatment of pediatric rhabdomyosarcoma) using cell lines. The RD cell line has a mutant P53 phenotype and does not have detectable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9ad634f9d9e0501d00450bc38d9ea90
https://pubmed.ncbi.nlm.nih.gov/11595714
https://pubmed.ncbi.nlm.nih.gov/11595714