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Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones

Autor: L R, Fodero, S S, Mok, D, Losic, L L, Martin, M I, Aguilar, C J, Barrow, B G, Livett, D H, Small

Publikováno v: Journal of neurochemistry. 88(5)

The beta-amyloid protein (Abeta) is the major protein component of amyloid plaques found in the Alzheimer brain. Although there is a loss of acetylcholinesterase (AChE) from both cholinergic and non-cholinergic neurones in the brain of Alzheimer pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e95f9b355314cd8604dac629a61f6c31
https://pubmed.ncbi.nlm.nih.gov/15009674

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Glycosylation of acetylcholinesterase and butyrylcholinesterase changes as a function of the duration of Alzheimer's disease

Autor: J, Sáez-Valero, L R, Fodero, M, Sjögren, N, Andreasen, S, Amici, V, Gallai, H, Vanderstichele, E, Vanmechelen, L, Parnetti, K, Blennow, D H, Small

Publikováno v: Journal of neuroscience research. 72(4)

The identification of biochemical markers of Alzheimer's disease (AD) may help in the diagnosis of the disease. Previous studies have shown that Abeta(1-42) is decreased, and tau and phospho-tau are increased in AD cerebrospinal fluid (CSF). Our own

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5d6ac1922d5a1bd4e85b921050c27bd
https://pubmed.ncbi.nlm.nih.gov/12704813

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Wheat germ agglutinin-binding glycoproteins are decreased in Alzheimer's disease cerebrospinal fluid

Autor: L R, Fodero, J, Sáez-Valero, M S, Barquero, A, Marcos, C A, McLean, D H, Small

Publikováno v: Journal of neurochemistry. 79(5)

A number of biomarkers (e.g. Abeta, tau) has been identified in Alzheimer's disease CSF. However, none fulfils the criteria of sensitivity and specificity (80%) needed for the development of an accurate diagnostic test. The lack of a suitable marker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d480beb118db6c4493e766090700625
https://pubmed.ncbi.nlm.nih.gov/11739614

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