Zobrazeno 1 - 10
of 19
pro vyhledávání: '"L P Schacter"'
Autor:
N Soni, L P Schacter, D Noel, K E Gunton, Patrick J. Creaven, Lakshmi Pendyala, Neal J. Meropol
Publikováno v:
Journal of Clinical Oncology. 15:766-772
PURPOSE Etoposide has schedule-dependent cytotoxic activity, and clinical resistance may be overcome with prolonged low-dose therapy. Oral bioavailability is variable, and protracted intravenous administration is limited by water insolubility, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e528d04539c8ef571b53f495c2d76ace
https://doi.org/10.1200/jco.1997.15.2.766
https://doi.org/10.1200/jco.1997.15.2.766
Autor:
John D. Hainsworth, N Levitan, J Randolph, G L Wampler, Chandra P. Belani, F. A. Greco, L P Schacter, M S Seyedsadr
Publikováno v:
Europe PubMed Central
PURPOSE This randomized phase II study evaluated the efficacy and toxicity of etoposide phosphate when used in combination with cisplatin in the treatment of small-cell lung cancer. PATIENTS AND METHODS Patients with previously untreated small-cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce223ac0bb71dc9324adf59f4abc950f
https://doi.org/10.1200/jco.1995.13.6.1436
https://doi.org/10.1200/jco.1995.13.6.1436
Autor:
S Z, Fields, D R, Budman, R R, Young, W, Kreis, R, Ingram, P, Schulman, R C, Cherny, J, Wright, J, Behr, C, Snow, L P, Schacter
Publikováno v:
Bone marrow transplantation. 18(5)
Etoposide is a widely used cytotoxic agent with a broad spectrum of activity in human malignancies. This agent has been incorporated into many transplant regimens although toxicity occurs because of its poor water solubility and toxic excipients. Eto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c06f3bb565b1cfeff1cbe7578ee2cbc2
https://pubmed.ncbi.nlm.nih.gov/8932836
https://pubmed.ncbi.nlm.nih.gov/8932836
Autor:
S Z, Fields, L N, Igwemezie, S, Kaul, L P, Schacter, R J, Schilder, P P, Litam, B S, Himpler, C, McAleer, J, Wright, R H, Barbhaiya
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 1(1)
Etoposide phophate is a phosphate ester prodrug of etoposide designed to improve the pharmaceutical characteristics of the parent compound. A Phase I dose-escalating study of etoposide phosphate was conducted concurrently at two institutions to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52c7a495c9f54f46d209f04f54f442ea
https://pubmed.ncbi.nlm.nih.gov/9815892
https://pubmed.ncbi.nlm.nih.gov/9815892
Autor:
L P, Schacter, C, Anderson, R M, Canetta, S, Kelley, C, Nicaise, N, Onetto, M, Rozencweig, L, Smaldone, B, Winograd
Publikováno v:
Seminars in oncology. 19(6)
The discovery and development of new anticancer drugs is a complex and largely empirical process. New compounds can be discovered by screening, modification of existing compounds, rational drug design, and serendipitous basic research observations. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fca216f5aea353e8dc1a2c298c909a8
https://pubmed.ncbi.nlm.nih.gov/1462163
https://pubmed.ncbi.nlm.nih.gov/1462163
Publikováno v:
Cancer research. 52(6)
Elsamitrucin (BMY-28090) is an antitumor antibiotic first described in 1985 that has significant oncolytic activity against a number of murine tumors including P388, L1210, B16 and M5076, as well as against MX1 and HCT116 xenografts. Preclinical toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d694ed6257516bb878efbb1ed6586566
https://pubmed.ncbi.nlm.nih.gov/1540949
https://pubmed.ncbi.nlm.nih.gov/1540949
Autor:
N C Cherng, Harvey J. Cohen, J A Randolph, G O Broun, Bruce J. Roth, David H. Johnson, L P Schacter, Jeffrey Crawford, Lawrence H. Einhorn, J L Goodlow
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 10(2)
PURPOSE The trial was undertaken to determine (1) the relative efficacy/toxicity of two commonly used combination chemotherapy regimens in patients with extensive small-cell lung cancer (SCLC) and (2) whether the rapid alternation of these two regime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5ac3e38ae0f7c8861b06fac969a008
https://pubmed.ncbi.nlm.nih.gov/1310103
https://pubmed.ncbi.nlm.nih.gov/1310103
Publikováno v:
Seminars in oncology. 17(6 Suppl 9)
Hormonal therapy of breast cancer is widely used and effective. Although never curative in advanced disease, significant palliation and durable remissions can be obtained with a wide variety of hormonal manipulations. Historically, surgical ablation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fc5dbba5ae1f04891986dc5a17009ec
https://pubmed.ncbi.nlm.nih.gov/2148026
https://pubmed.ncbi.nlm.nih.gov/2148026
Autor:
L. P. Schacter
Publikováno v:
European Journal of Clinical Investigation. 16:204-210
To test the hypothesis that the resistance of sickle trait (AS Hgb) erythrocytes (rbcs) to malaria may be mediated by increased production of activated oxygen species, the production of superoxide anion (O2-) and hydrogen peroxide (H2O2) by AS rbcs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcd15c5bdfa271df6d51025ae225abe
https://doi.org/10.1111/j.1365-2362.1986.tb01330.x
https://doi.org/10.1111/j.1365-2362.1986.tb01330.x
Autor:
L. P. Schacter
Publikováno v:
JAMA: The Journal of the American Medical Association. 237:1848-1851
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76b23936fcca08f6bbb12e5de190ea65
https://doi.org/10.1001/jama.237.17.1848
https://doi.org/10.1001/jama.237.17.1848