Zobrazeno 1 - 10 of 16 pro vyhledávání: '"L P, Wakelin"'
1
Measurement of rate of anion exchange and the effect of organic fouling
Autor: H. K. Wall, L. P. Wakelin
Publikováno v: Journal of Applied Chemistry and Biotechnology. 21:1-4
A method has been developed for the examination of rates of reaction of a strongly basic ion-exchange resin with a large organic anion. The results indicate that an organically fouled resin reacts at a slower rate than an unfouled one under standard
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::108a39a7fc39e1d9a4bd7ba1ac6ee7b3
https://doi.org/10.1002/jctb.5020210101
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2
Review: DNA molecular electrostatic potential: novel perspectives for the mechanism of action of anticancer drugs involving electron transfer and oxidative stress
Autor: P, Kovacic, L P, Wakelin
Publikováno v: Anti-cancer drug design. 16(4-5)
This report examines the mechanism of action of DNA-binding anticancer drugs that involve electron transfer and oxidative stress, and primarily focuses on neglected issues surrounding molecular electrostatic potentials (MEP), the energetics of initia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d23b92ab40abfd4313dd4a2b9fcd1645
https://pubmed.ncbi.nlm.nih.gov/12049476
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4
Synthesis, DNA binding interactions and biological activity of bis platinum (II) complexes of N,N,N',N'-tetrakis(2-aminoethyl)diamines
Autor: B D, Palmer, G, Wickham, D J, Craik, W D, McFadyen, L P, Wakelin, B C, Baguley, W A, Denny
Publikováno v: Anti-cancer drug design. 7(5)
A series of dimers of the monofunctional platinum species [Pt(dien)Cl]+, linked by a variety of flexible (polymethylene) and more rigid chains, was prepared and evaluated for DNA interactions and cytotoxic activity. The polymethylene-linked dimers we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f501493e7bf9a1e17b65d601e2a60c1a
https://pubmed.ncbi.nlm.nih.gov/1388630
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5
Synthesis and anti-tumour activity of the spatially-separated mustard bis-N,N'-[3-(N-(2-chloroethyl)-N-ethyl)amino-5-[N,N-dimethylamino)methy l)-aminophenyl]-1,4-benzenedicarboxamide, which alkylates DNA exclusively at adenines in the minor groove
Autor: A S, Prakash, K K, Valu, L P, Wakelin, P D, Woodgate, W A, Denny
Publikováno v: Anti-cancer drug design. 6(3)
The mustard derivative, bis-N,N'-[3-(N-(2-chloroethyl)-N-ethyl)amino-5- [N,N-dimethylamino)methyl)aminophenyl]-1,4-benzenedicarboxamide has been synthesized from 3-acetamido-5-nitrobenzoic acid in a 6-step procedure. This compound alkylates exclusive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f9d40f9feb85781566c2ae184b1ede1
https://pubmed.ncbi.nlm.nih.gov/1872947
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6
Conformation and dynamics of the deoxyribose rings of a (nogalamycin)2-d (5'-GCATGC)2 complex studied in solution by 1H-n.m.r. spectroscopy
Autor: M S Searle, L P Wakelin
The conformation and dynamics of the deoxyribose rings of a (nogalamycin)2-d(5′-GCATGC)2 complex have been determined from an analysis of 1H-1H vicinal coupling constants and sums of coupling constants (J1′-2′,J1′-2″,epsilon 1′, epsilon 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367afe2cbe293ec43c13d28974536d7f
https://europepmc.org/articles/PMC1131582/
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7
Sequence specific conformation of a DNA decamer containing an adenine tract studied in solution by H-NMR spectroscopy
Autor: M S, Searle, L P, Wakelin
Publikováno v: Biochimica et biophysica acta. 1049(1)
The decanucleotide duplex d(AAAACGTTTT)2 and a variety of phase-sensitive two-dimensional (2D) NMR experiments have been used to investigate the solution conformation of an adenine-tract and its junction with another DNA sequence. 2D nuclear Overhaus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::134935d185502009cacfe83ed73b143b
https://pubmed.ncbi.nlm.nih.gov/2357466
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8
Kinetics of the binding of mitoxantrone, ametantrone and analogues to DNA: relationship with binding mode and anti-tumour activity
Autor: W A, Denny, L P, Wakelin
Publikováno v: Anti-cancer drug design. 5(2)
The kinetics of association and dissociation of DNA complexes of the anti-tumour agents mitoxantrone, ametantrone and related 1,4-bis(alkylamino)anthraquinones have been determined by stopped-flow spectrophotometry, in order to study relationships be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c211f6f5abf83338db7f784fb93e0cf
https://pubmed.ncbi.nlm.nih.gov/2357264
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10
Electrostatic components of drug-receptor recognition. I. Structural and sequence analogues of DNA polynucleotides
Autor: P M, Dean, L P, Wakelin
Publikováno v: Proceedings of the Royal Society of London. Series B, Biological sciences. 209(1177)
The electrostatic fields associated with the important biological receptor DNA have been studied by means of stereoscopic displays to investigate drug-receptor recognition processes. This revealed great differences between A- and B-type structures an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d1bd725d2c4470c31187b160b7231a73
https://pubmed.ncbi.nlm.nih.gov/6107920
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