Výsledky vyhledávání - "L P, Wakelin"

Measurement of rate of anion exchange and the effect of organic fouling

Autor: H. K. Wall, L. P. Wakelin

Publikováno v: Journal of Applied Chemistry and Biotechnology. 21:1-4

A method has been developed for the examination of rates of reaction of a strongly basic ion-exchange resin with a large organic anion. The results indicate that an organically fouled resin reacts at a slower rate than an unfouled one under standard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::108a39a7fc39e1d9a4bd7ba1ac6ee7b3
https://doi.org/10.1002/jctb.5020210101

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Review: DNA molecular electrostatic potential: novel perspectives for the mechanism of action of anticancer drugs involving electron transfer and oxidative stress

Autor: P, Kovacic, L P, Wakelin

Publikováno v: Anti-cancer drug design. 16(4-5)

This report examines the mechanism of action of DNA-binding anticancer drugs that involve electron transfer and oxidative stress, and primarily focuses on neglected issues surrounding molecular electrostatic potentials (MEP), the energetics of initia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d23b92ab40abfd4313dd4a2b9fcd1645
https://pubmed.ncbi.nlm.nih.gov/12049476

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Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution

Autor: A K, Todd, A, Adams, J H, Thorpe, W A, Denny, L P, Wakelin, C J, Cardin

Publikováno v: Journal of medicinal chemistry. 42(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a460a984e0e49c12d2b1895e2bfaf063
https://pubmed.ncbi.nlm.nih.gov/10052960

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Synthesis, DNA binding interactions and biological activity of bis platinum (II) complexes of N,N,N',N'-tetrakis(2-aminoethyl)diamines

Autor: B D, Palmer, G, Wickham, D J, Craik, W D, McFadyen, L P, Wakelin, B C, Baguley, W A, Denny

Publikováno v: Anti-cancer drug design. 7(5)

A series of dimers of the monofunctional platinum species [Pt(dien)Cl]+, linked by a variety of flexible (polymethylene) and more rigid chains, was prepared and evaluated for DNA interactions and cytotoxic activity. The polymethylene-linked dimers we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f501493e7bf9a1e17b65d601e2a60c1a
https://pubmed.ncbi.nlm.nih.gov/1388630

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Synthesis and anti-tumour activity of the spatially-separated mustard bis-N,N'-[3-(N-(2-chloroethyl)-N-ethyl)amino-5-[N,N-dimethylamino)methy l)-aminophenyl]-1,4-benzenedicarboxamide, which alkylates DNA exclusively at adenines in the minor groove

Autor: A S, Prakash, K K, Valu, L P, Wakelin, P D, Woodgate, W A, Denny

Publikováno v: Anti-cancer drug design. 6(3)

The mustard derivative, bis-N,N'-[3-(N-(2-chloroethyl)-N-ethyl)amino-5- [N,N-dimethylamino)methyl)aminophenyl]-1,4-benzenedicarboxamide has been synthesized from 3-acetamido-5-nitrobenzoic acid in a 6-step procedure. This compound alkylates exclusive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f9d40f9feb85781566c2ae184b1ede1
https://pubmed.ncbi.nlm.nih.gov/1872947

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Conformation and dynamics of the deoxyribose rings of a (nogalamycin)2-d (5'-GCATGC)2 complex studied in solution by 1H-n.m.r. spectroscopy

Autor: M S Searle, L P Wakelin

The conformation and dynamics of the deoxyribose rings of a (nogalamycin)2-d(5′-GCATGC)2 complex have been determined from an analysis of 1H-1H vicinal coupling constants and sums of coupling constants (J1′-2′,J1′-2″,epsilon 1′, epsilon 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367afe2cbe293ec43c13d28974536d7f
https://europepmc.org/articles/PMC1131582/

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Sequence specific conformation of a DNA decamer containing an adenine tract studied in solution by H-NMR spectroscopy

Autor: M S, Searle, L P, Wakelin

Publikováno v: Biochimica et biophysica acta. 1049(1)

The decanucleotide duplex d(AAAACGTTTT)2 and a variety of phase-sensitive two-dimensional (2D) NMR experiments have been used to investigate the solution conformation of an adenine-tract and its junction with another DNA sequence. 2D nuclear Overhaus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::134935d185502009cacfe83ed73b143b
https://pubmed.ncbi.nlm.nih.gov/2357466

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Kinetics of the binding of mitoxantrone, ametantrone and analogues to DNA: relationship with binding mode and anti-tumour activity

Autor: W A, Denny, L P, Wakelin

Publikováno v: Anti-cancer drug design. 5(2)

The kinetics of association and dissociation of DNA complexes of the anti-tumour agents mitoxantrone, ametantrone and related 1,4-bis(alkylamino)anthraquinones have been determined by stopped-flow spectrophotometry, in order to study relationships be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c211f6f5abf83338db7f784fb93e0cf
https://pubmed.ncbi.nlm.nih.gov/2357264

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Akademický článek

In vitro Analytical Techniques as Screening Tools to investigate the Metal chelate‐DNA interactions.

Autor: Varghese, Nikita¹ (AUTHOR), Jose, Joyna Reba¹ (AUTHOR), Krishna, P. Murali² (AUTHOR), Philip, Darit¹ (AUTHOR), Joy, Francis¹ (AUTHOR), Vinod, T. P.¹ (AUTHOR), Prathapachandra Kurup, M. R.³ (AUTHOR) mrp@cukerala.ac.in, Nair, Yamuna¹ (AUTHOR) yamuna.nair@christuniversity.in

Publikováno v: ChemistrySelect. 2/3/2023, Vol. 8 Issue 5, p1-28. 28p.

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