Zobrazeno 1 - 10
of 20
pro vyhledávání: '"L P, Dwoskin"'
Publikováno v:
Biochemical pharmacology. 62(12)
Nornicotine is a tobacco alkaloid and an active nicotine metabolite, which accumulates in brain to pharmacologically relevant concentrations following repeated nicotine administration to rats. Furthermore, nornicotine is self-administered by rats, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f537a92bffa4f1927294b8ab459f3560
https://pubmed.ncbi.nlm.nih.gov/11755112
https://pubmed.ncbi.nlm.nih.gov/11755112
Autor:
L P, Dwoskin, P A, Crooks
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(2)
Neuronal nicotinic acetylcholine receptors are distributed extensively throughout the central and peripheral nervous systems. Currently, there is great interest in determining the structural and functional diversity of these receptors, and in develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45a334332e1d558c2f1587b88d7ffd4b
https://pubmed.ncbi.nlm.nih.gov/11454899
https://pubmed.ncbi.nlm.nih.gov/11454899
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(1)
alpha-Lobeline inhibits d-amphetamine-evoked dopamine release from striatal slices in vitro, appearing to reduce the cytosolic pool of dopamine available for reverse transport by the dopamine transporter. Based on this neurochemical mechanism of acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50481233a0996695eec043ef6328fcfe
https://pubmed.ncbi.nlm.nih.gov/11408539
https://pubmed.ncbi.nlm.nih.gov/11408539
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
Concentrations of nicotine, cotinine, and nornicotine in brain and blood following both intermittent and continuous administration of [2'-(14)C]nicotine to rats were determined to assess nicotine metabolite accumulation in brain following repeated ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84bdc6229dfbdfe443dba0228dc45bbc
https://pubmed.ncbi.nlm.nih.gov/11302929
https://pubmed.ncbi.nlm.nih.gov/11302929
Autor:
D K, Miller, P A, Crooks, L, Teng, J M, Witkin, P, Munzar, S R, Goldberg, J B, Acri, L P, Dwoskin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(3)
Lobeline interacts with the dopamine transporter and vesicular monoamine transporter, presynaptic proteins involved in dopamine storage and release. This study used rodent models to assess lobeline-induced inhibition of the neurochemical and behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::868b6b07f96eb728125fe3891e78f57f
https://pubmed.ncbi.nlm.nih.gov/11181937
https://pubmed.ncbi.nlm.nih.gov/11181937
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(12)
The residence times of nicotine and its metabolites in rat brain after acute peripheral nicotine administration were determined. We hypothesize that nicotine metabolites will reach pharmacologically significant concentrations in brain. Cotinine, norn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::708c06bfc49cbe3387b40b634dd1cdb4
https://pubmed.ncbi.nlm.nih.gov/10570026
https://pubmed.ncbi.nlm.nih.gov/10570026
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(3)
Cotinine, a major peripheral metabolite of nicotine, has recently been shown to be the most abundant metabolite in rat brain after peripheral nicotine administration. However, little attention has been focused on the contribution of cotinine to the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd6039a799126407c737d47e8deeb4a5
https://pubmed.ncbi.nlm.nih.gov/10027825
https://pubmed.ncbi.nlm.nih.gov/10027825
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(2)
Previous results from our laboratory demonstrated that S(-)nornicotine, a major tobacco alkaloid and an active nicotine metabolite present in the CNS, increases dopamine release from rat striatal slices in a concentration-dependent and calcium-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d4d6508016ff3a22f9dc16142769250
https://pubmed.ncbi.nlm.nih.gov/9353398
https://pubmed.ncbi.nlm.nih.gov/9353398
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(1)
The reinforcing effects of many psychomotor stimulants have been related to increased dopaminergic neurotransmission and stimulation of central nervous system (CNS) dopamine (DA) receptors. Consistent with this notion, some drugs that directly stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::561463b4226eb2c399b7d6b01e0cd421
https://pubmed.ncbi.nlm.nih.gov/9336305
https://pubmed.ncbi.nlm.nih.gov/9336305
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(3)
Lobeline is currently being developed as a substitution therapy for tobacco smoking cessation. Activation of CNS dopamine (DA) systems results in the reinforcing properties of nicotine. The present study compared the effects of lobeline and nicotine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b28a280562f6ec932fca31497263cae8
https://pubmed.ncbi.nlm.nih.gov/9067333
https://pubmed.ncbi.nlm.nih.gov/9067333