BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy

Autor: L. Nevi, Panagis Filippakopoulos, Raffaella Fittipaldi, Marco Segatto, Roberta Szokoll, Kamel Mamchaoui, Cinzia Bottino, Giuseppina Caretti

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.6108. ⟨10.1038/s41467-020-19839-x⟩
Nature Communications, 2020, 11 (1), pp.6108. ⟨10.1038/s41467-020-19839-x⟩

Duchenne muscular dystrophy (DMD) affects 1 in 3500 live male births. To date, there is no effective cure for DMD, and the identification of novel molecular targets involved in disease progression is important to design more effective treatments and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e4ccdc045c085b0ec027c5b4ee9b8e
https://doaj.org/article/55e92e9f04a24679a1d5b129a0da42cf

Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells

Autor: Cesare Manetti, Guido Carpino, Daniele Costantini, Fabio Melandro, Sabina Di Matteo, Vincenzo Cardinale, Eugenio Gaudio, Mariacristina Valerio, Domenico Alvaro, L. Nevi, Pasquale Berloco, Luca Casadei, Mariano Bizzarri, S. Safarikia, Diletta Overi

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports

Many pivotal biological cell processes are affected by gravity. The aim of our study was to evaluate biological and functional effects, differentiation potential and exo-metabolome profile of simulated microgravity (SMG) on human hepatic cell line (H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10db1313fa5aac7a031a3bc509883c6
http://link.springer.com/article/10.1038/s41598-019-41908-5

Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro

Autor: Vincenzo Cardinale, Pasquale Berloco, Sabina Di Matteo, Daniele Costantini, Fabio Melandro, S. Safarikia, L. Nevi

Publikováno v: Cells, Vol 8, Iss 11, p 1443 (2019)
Cells
Volume 8
Issue 11

Human biliary tree stem/progenitor cells (hBTSCs), reside in peribiliary glands, are mainly stimulated by primary sclerosing cholangitis (PSC) and cholangiocarcinoma. In these pathologies, hBTSCs displayed epithelial-to-mesenchymal transition (EMT),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c6c1dd4bb8c593b2f1e22513e93155
https://www.mdpi.com/2073-4409/8/11/1443

Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis

Autor: Guido Carpino, Pasquale Berloco, L. Nevi, Paolo Onori, Diletta Overi, Stuart J. Forbes, S. Safarikia, Sabina Di Matteo, Domenico Alvaro, Vincenzo Cardinale, Wei-Yu Lu, Rosanna Venere, Eugenio Gaudio, Antonio Franchitto

Publikováno v: Carpino, G, Nevi, L, Overi, D, Cardinale, V, Lu, W-Y, Di Matteo, S, Safarikia, S, Berloco, P B, Venere, R, Onori, P, Franchitto, A, Forbes, S J, Alvaro, D & Gaudio, E 2019, ' Peribiliary gland niche participates in biliary tree regeneration in mouse and in human primary sclerosing cholangitis ', Hepatology . https://doi.org/10.1002/hep.30871

Mechanisms underlying the repair of extrahepatic biliary tree (EHBT) after injury have been scarcely explored. The aims of this study were to evaluate, by using a lineage tracing approach, the contribution of peribiliary gland (PBG) niche in the rege

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f607a95a9c97dc4ccf116e19a7693930
http://hdl.handle.net/11573/1336258

PS-123-Biliary tree stem/progenitor cells mediate the regeneration in biliary lining after injury

Autor: Vincenzo Cardinale, Pasquale Berloco, L. Nevi, Stuart J. Forbes, Daniele Constantini, Wei-Yu Lu, Domenico Alvaro, Fabio Melandro, S. Safarikia, Eugenio Gaudio, Sabina Di Matteo

Publikováno v: Journal of Hepatology. 70:e76-e77

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89898763da4eba3ba721dd059296601a
https://doi.org/10.1016/s0618-8278(19)30135-5