Zobrazeno 1 - 10 of 207 pro vyhledávání: '"L Nagelkerken"'
1
CC Chemokine Ligand-5 (CCL5/RANTES) and CC Chemokine Ligand-18 (CCL18/PARC) Are Specific Markers of Refractory Unstable Angina Pectoris and Are Transiently Raised During Severe Ischemic Symptoms
Autor: E.A.L. Biessen, Hein Putter, Shaun R. McColl, S.C.A. de Jager, Joop Jukema, Adriaan O. Kraaijeveld, T. J. C. Van Berkel, W. de Jager, I. Haspels, L. Nagelkerken, Berent J. Prakken
Publikováno v: Circulation, 17, 116, 1931-1941
Background—Chemokines play an important role in atherogenesis and in ischemic injury and repair; however, prospective data on individual chemokines in unstable angina pectoris (UAP) are scarce. Therefore, we assessed chemokine patterns in a prospec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43474d213dcc865e7714a815a33320c0
https://doi.org/10.1161/circulationaha.107.706986
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2
Subjective Sleep Quality and Depressive Symptoms in Patients with the Chronic Fatigue Syndrome
Autor: M. P. Springer, A Knuistingh Neven, AW Graffelman, H. Petri, L. Nagelkerken
Publikováno v: Journal of Chronic Fatigue Syndrome. 10:19-28
Objectives: To evaluate subjective quality of sleep and depressive symptoms of patients with chronic fatigue syndrome (CFS).Methods: Adult patients, who met the criteria for CFS, were recruited by general practitioners in the Leiden area, The Netherl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db6f0936b6d861941bfec07888b396ff
https://doi.org/10.1300/j092v10n02_03
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3
Contrasting responses to interferon β-1b treatment in relapsing-remitting multiple sclerosis: Does baseline interleukin-12p35 messenger RNA predict the efficacy of treatment?
Autor: L. Nagelkerken, S. C. J. Van Trigt-Hoff, A.H.H. van Boxel-Dezaire, Hans M. Schrijver, Joep Killestein, Chris H. Polman, J.C. van Houwelingen
Publikováno v: Annals of Neurology. 48:313-322
Interferon (IFN)-β treatment is effective in relapsing-remitting multiple sclerosis (RR-MS) via an as yet unidentified mechanism. In the present study, we investigated whether the expression of messenger RNA (mRNA) encoding the interleukin (IL)-12 s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d271210fa584f22daaad5c707bc8bf4
https://doi.org/10.1002/1531-8249(200009)48:3<313::aid-ana5>3.0.co
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4
Mediators of apoptosis Fas and FasL predict disability progression in multiple sclerosis over a period of 10 years
Autor: Luba Lopatinskaya, B.M.J. Uitdehaag, Chris H. Polman, L Nagelkerken, K Lucas, J. Zwemmer
Publikováno v: Multiple Sclerosis, 6, 12, 704-709
TNF-α, IL-12p35, IL-12p40, IL-4, IL-10, TGF-β1, CCR3, CXCR3, CCR5, Fas and FasL mRNA levels in PBMC of 25 multiple sclerosis (MS) patients were quantified at baseline by real-time PCR according to a post-hoc study design. The baseline values of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616e1038666e9610c386d1219be41ed1
http://resolver.tudelft.nl/uuid:f4e27b4f-3b75-4a1f-9eeb-59b7f9b78b43
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5
Soluble vascular cell adhesion molecule (VCAM) is associated with treatment effects of Interferon beta-1b in patients with Secondary Progressive Multiple Sclerosis
Autor: S. Stürzebecher, Niels Kruse, L. Nagelkerken, K. Beckmann, K.V. Toyka, Peter Rieckmann, Frank Dahlke, H.-P. Hartung, Chris H. Polman, David Miller
Publikováno v: Journal of Neurology, 5, 252, 526-533
Background: Subcutaneous IFNβ-1b (Betaferon®) is an established immunomodulatory treatment for relapsing remitting MS and active secondary progressive multiple sclerosis (SPMS). It modulates cytokine and adhesion molecule expression but long term i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae72938e2c486c36d4b3ad645b7b2b18
http://resolver.tudelft.nl/uuid:84dacb6f-63b4-4881-904d-387cf29b7fec
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6
Increased sensitivity to glucocorticoids in peripheral blood mononuclear cells of chronic fatigue syndrome patients, without evidence for altered density or affinity of glucocorticoid receptors
Autor: W. Graffelman, Jeroen Visser, I. Haspels, B. Blauw, L. Nagelkerken, Eef G.W.M. Lentjes, R. de Kloet
Publikováno v: Scopus-Elsevier
Journal of Investigative Medicine, 2, 49, 195-204
Background In this study we tested the hypothesis that the increased sensitivity to glucocorticoids in chronic fatigue syndrome (CFS)-patients can be attributed to an altered functioning of their glucocorticoid receptors (GR). Methods For this purpos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45f088809bb372abb7dcb53b6f09daa
https://pubmed.ncbi.nlm.nih.gov/11288761
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7
Contrasting responses to interferon beta-1b treatment in relapsing-remitting multiple sclerosis: does baseline interleukin-12p35 messenger RNA predict the efficacy of treatment?
Autor: A H, van Boxel-Dezaire, S C, van Trigt-Hoff, J, Killestein, H M, Schrijver, J C, van Houwelingen, C H, Polman, L, Nagelkerken
Publikováno v: Annals of neurology. 48(3)
Interferon (IFN)-beta treatment is effective in relapsing-remitting multiple sclerosis (RR-MS) via an as yet unidentified mechanism. In the present study, we investigated whether the expression of messenger RNA (mRNA) encoding the interleukin (IL)-12
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de63b93e5b43636ecb230ffa33d9f75a
https://pubmed.ncbi.nlm.nih.gov/10976637
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8
Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis
Autor: A H, van Boxel-Dezaire, S C, Hoff, B W, van Oosten, C L, Verweij, A M, Dräger, H J, Adèr, J C, van Houwelingen, F, Barkhof, C H, Polman, L, Nagelkerken
Publikováno v: Annals of neurology. 45(6)
It has been shown that proinflammatory and antiinflammatory cytokines correlate with disease activity in multiple sclerosis (MS). To establish whether such correlations depend on the disease stage, we assessed in a longitudinal fashion the expression
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::830721ddc70e157f43e2060e7fe86cfa
https://pubmed.ncbi.nlm.nih.gov/10360759
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9
IL-4 abrogates the inhibitory effect of IL-10 on the development of experimental allergic encephalomyelitis in SJL mice
Autor: L, Nagelkerken, B, Blauw, M, Tielemans
Publikováno v: International immunology. 9(9)
IL-10 and IL-4 were studied with respect to their capacity to inhibit experimental allergic encephalomyelitis (EAE) induced in SJL/J mice by immunization with the proteolipid protein peptide PLP139-151. Treatment with 2 micrograms IL-10/day from day
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::812ca8b2bf36c01419e905f9b3bfe90e
https://pubmed.ncbi.nlm.nih.gov/9310827
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10
Identification of distinct sites of beta-endorphin that stimulate lymphokine production by murine CD4+ T cells
Autor: P, Van den Bergh, J, Rozing, L, Nagelkerken
Publikováno v: Lymphokine and cytokine research. 13(2)
We recently demonstrated that the opioid peptide beta-endorphin (beta-End) has the capacity to stimulate interleukin-2 (IL-2) and IL-4 production by murine CD4+ T cells. Since opioid peptides have been demonstrated to contain stimulatory as well as i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::958c213f6b7564fbde197f32fa7598b2
https://pubmed.ncbi.nlm.nih.gov/7914752
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