Výsledky vyhledávání

Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas

Autor: W S, Samowitz, M D, Powers, L N, Spirio, F, Nollet, F, van Roy, M L, Slattery

Publikováno v: Cancer research. 59(7)

Loss of serine or threonine phosphorylation sites from exon 3 of beta-catenin has been identified in approximately half of colorectal tumors which lack adenomatous polyposis coli (APC) mutations, but the overall contribution of beta-catenin mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a51d7c14aa989dd888da110fc5e4b46
https://pubmed.ncbi.nlm.nih.gov/10197610

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The inducible prostaglandin biosynthetic enzyme, cyclooxygenase 2, is not mutated in patients with attenuated adenomatous polyposis coli

Autor: L N, Spirio, D A, Dixon, J, Robertson, M, Robertson, J, Barrows, E, Traer, R W, Burt, M F, Leppert, R, White, S M, Prescott

Publikováno v: Cancer research. 58(21)

Germ-line mutations in the APC gene cause adenomatous polyposis coli (APC), a syndrome in which patients develop hundreds to thousands of precancerous adenomatous colorectal polyps. We described previously an attenuated form of APC (AAPC) resulting f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1aa5b2f39cdff081af76108c7df0a5ab
https://pubmed.ncbi.nlm.nih.gov/9809998

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Three secretory phospholipase A(2) genes that map to human chromosome 1P35-36 are not mutated in individuals with attenuated adenomatous polyposis coli

Autor: L N, Spirio, W, Kutchera, M V, Winstead, B, Pearson, C, Kaplan, M, Robertson, E, Lawrence, R W, Burt, J A, Tischfield, M F, Leppert, S M, Prescott, R, White

Publikováno v: Cancer research. 56(5)

Mutation of Pla2g2a, a secretory phospholipase A(2) gene, dramatically increases the number of intestinal polyps that develop in the multiple intestinal neoplasia (Min) mouse, a murine model for adenomatous polyposis coli in humans. We tested the hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4029a4ec8cf4295ce98ec290c2f7959a
https://pubmed.ncbi.nlm.nih.gov/8640784

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Alternatively spliced adenomatous polyposis coli (APC) gene transcripts that delete exons mutated in attenuated APC

Autor: W S, Samowitz, A, Thliveris, L N, Spirio, R, White

Publikováno v: Cancer research. 55(17)

Reverse transcription-PCR combined with either (a) restriction enzyme digestion and repeat PCR or (b) ligase chain reaction has identified two new alternatively spliced transcripts of the adenomatous polyposis coli (APC) gene. In one of these transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d268a90859e949f0ac3647bf918dc113
https://pubmed.ncbi.nlm.nih.gov/7641184

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