Výsledky vyhledávání - "L N, Shingarova"

Increased Synthesis of a Magnesium Transporter MgtA During Recombinant Autotransporter Expression in Escherichia coli

Autor: D. A. Dolgikh, L. N. Shingarova, Alexander V. Zlobinov, Rustam H. Ziganshin, Vasiliy A. Mironov, S. Sh. Gapizov, Lada E. Petrovskaya, Mikhail P. Kirpichnikov, G.Y. Lomakina, E. A. Kryukova

Publikováno v: Applied biochemistry and biotechnology. 193(11)

Overproduction of the membrane proteins in Escherichia coli cells is a common approach to obtain sufficient material for their functional and structural studies. However, the efficiency of this process can be limited by toxic effects which decrease t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399fa94a4a25714b2408434fa0d9fcbc
https://pubmed.ncbi.nlm.nih.gov/34351586

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Engineering of Thermal Stability in a Cold-Active Oligo-1,6-Glucosidase from Exiguobacterium sibiricum with Unusual Amino Acid Content

Autor: E. A. Kryukova, S. Sh. Gapizov, M.V. Kryukova, Elizaveta Rivkina, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh, Yana Y. Berlina, Lada E. Petrovskaya, L. N. Shingarova

Publikováno v: Biomolecules, Vol 11, Iss 1229, p 1229 (2021)
Biomolecules
Volume 11
Issue 8

A gene coding for a novel putative amylase, oligo-1,6-glucosidase from a psychrotrophic bacterium Exiguobacterium sibiricum from Siberian permafrost soil was cloned and expressed in Escherichia coli. The amino acid sequence of the predicted protein E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8e6876a82d883b7b15aef701fcb8b4
https://doi.org/10.3390/biom11081229

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Fusion with an albumin-binding domain improves pharmacokinetics of an αvβ3-integrin binding fibronectin scaffold protein

Autor: S. A. Yakimov, S. Sh. Gapizov, D. A. Dolgikh, E. A. Kryukova, Lada E. Petrovskaya, Mikhail P. Kirpichnikov, E. V. Svirshchevskaya, E. P. Lukashev, E. F. Boldyreva, L. N. Shingarova

Publikováno v: Biotechnology and applied biochemistryReferences. 66(4)

Fusion with an albumin-binding domain (ABD) of streptococcal protein G represents a popular approach for half-life extension of small protein therapeutics in the organism. To increase the circulation time of engineered αvβ3-integrin-binding protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57fa49a7b1983482289124674a50486
https://pubmed.ncbi.nlm.nih.gov/31140614

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Tumor necrosis factor-alpha is a potential target for the neuroprotector Dimebon

Autor: A. V. Alessenko, S. V. Gurianova, L N Shingarova, Sergey O. Bachurin, Y. O. Karatasso, Elena F. Shevtsova

Publikováno v: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 9:189-198

Since 1983, Dimebon (Dimebolin) is used clinically in Russia as an antihistamine drug. Recent interest in Dimebolin is associated with its therapeutic effect in patients with Alzheimer’s disease. Animal studies have shown that Dimebon activity is r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63edf00f8ecda01d54ca5faac065af38
https://doi.org/10.1134/s199075081502002x

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[Tumor necrosis faсtor-alpha - potential target for neuroprotector dimebon]

Autor: L N Shingarova, A. V. Alessenko, S. V. Gurianova, Y. O. Karatasso, Elena F. Shevtsova, Sergey O. Bachurin

Publikováno v: Biomeditsinskaia khimiia. 62(4)

Dimebon (Dimebolin) is an antihistamine drug which has been used in Russia since 1983. Recently Dimebolin has attracted renewed interest after being shown to have positive effects on persons suffering from Alzheimer's disease. Animal studies have sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8503cd0b1f664524307f5b0872110727
https://pubmed.ncbi.nlm.nih.gov/27562995

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The combined application of nucleotide and amino acid sequences of NS3 hepatitis C virus protein, DNA encoding granulocyte macrophage colony-stimulating factor, and inhibitor of regulatory T cells induces effective immune responce against Hepatitis C virus

Autor: O. V. Masalova, L. N. Shingarova, Alla A. Kushch, V L Tunitskaia, Burkov An, Ulanova Ti, E. I. Lesnova

Publikováno v: Molecular Biology. 46:473-480

Hepatitis C is related to the most important socially significant human infectious diseases; however, vaccine against this virus up to now has notbeen created. One of the possible components of vaccine is the nonstructural protein NS3 of hepatitis C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d25b44ae82539958e8efa3cd1adcda4f
https://doi.org/10.1134/s0026893312030077

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Human single-chain antibodies specific to the tumor necrosis factor

Autor: Nina V. Tikunova, M. P. Kirpichnikov, L. R. Lebedev, T. A. Batanova, M. A. Vikhrova, Ludmila A. Frank, L. N. Shingarova

Publikováno v: Russian Journal of Bioorganic Chemistry. 37:298-306

Six unique phage antibodies against human tumor necrosis factor (TNF) were selected from the earlier constructed naive combinatorial library of single-chain antibodies by affinity selection. The TNF binding of these antibodies was examined by enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf74b6fd40e0eef926e0c2607d2d0888
https://doi.org/10.1134/s1068162011030198

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Expression and properties of human TNF peptide fragments

Autor: L. N. Shingarova, S. V. Guryanova, S. A. Yakimov, E. F. Boldyreva, Alexei N. Nekrasov, E. A. Kryukova, Mikhail P. Kirpichnikov, D. A. Dolgih, Lada E. Petrovskaya

Publikováno v: Russian Journal of Bioorganic Chemistry. 36:301-309

The tumor necrosis factor (TNF) is a proinflammatory cytokine that plays a pivotal role in the regulation of the human immune system. Studies of the TNF functional topography are a challenging task in bioengineering. We have produced genes encoding t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::091c7f504c4b855fd8a6b8fcb41dff0b
https://doi.org/10.1134/s1068162010030040

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Mechanism of interaction of tumor necrosis factor (TNF-a) of macroorganism with Salmonella Enterica cells (Ser. Typhimurium)

Autor: Tomova As, Alexander L. Gintsburg, Yu. M. Romanova, Anna S. Karyagina, Vladimir G. Lunin, I. P. Lupu, L. N. Shingarova

Publikováno v: Molecular Genetics, Microbiology and Virology. 23:178-183

The goal of this work was to elucidate the mechanism of the direct interaction of bacteria cells with tumor necrosis factor (TNF-α, cytokine). It was shown previously that this interaction facilitated the activation of the bacterial growth and recul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2148f145800730e75a5c1db386e1ef9
https://doi.org/10.3103/s0891416808040046

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Recombinant full-size human antibody to Ebola virus

Autor: Lev S. Sandakhchiev, Oksana V. Nekrasova, T. K. Aliev, Nina V. Tikunova, T. A. Batanova, A. A. Panina, L. N. Shingarova, E. F. Boldyreva, A. A. Chepurnov, V. A. Toporova, T. E. Yun, Kirpichnikov Mp

Publikováno v: Scopus-Elsevier

A full-size human antibody to Ebola virus was constructed by joining genes encoding the constant domains of the heavy and light chains of human immunoglobulin with the corresponding DNA fragments encoding variable domains of the single-chain antibody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a34159fd7f89ce48f8d2368f1e99f3
https://doi.org/10.1134/s1068162007060040

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