Zobrazeno 1 - 10
of 113
pro vyhledávání: '"L N, Nerobkova"'
Publikováno v:
Эпилепсия и пароксизмальные состояния, Vol 11, Iss 1, Pp 37-45 (2019)
The aim was to study the effect of lacosamide on epileptiform activity (EрA) and structure-function relations in the brain in the course of development of the epileptic system in rats with cobalt-induced chronic epilepsy. Materials and methods. To m
Externí odkaz:
https://doaj.org/article/ed9cdb8aeda54dbb9d8a61cbae9fcb48
Publikováno v:
Эпилепсия и пароксизмальные состояния, Vol 10, Iss 4, Pp 26-38 (2019)
The aim is to develop an antiepileptic drug based on polymer nanoparticles with 2-ethyl-6-methyl-3-oxypyridine succinate to facilitate the drug transport through the blood-brain barrier.Materials and methods. The nano-drug was created using the biolo
Externí odkaz:
https://doaj.org/article/7193104d1e4c449e8d5fd1492861b7a3
Autor:
S. A. Litvinova, T. A. Voronina, L. N. Nerobkova, I. S. Kutepova, G. G. Avakyan, G. N. Avakyan
Publikováno v:
Эпилепсия и пароксизмальные состояния, Vol 10, Iss 1, Pp 52-62 (2018)
The aim of this study was to evaluate the anti-seizure effect of Levetinol tablet (Geropharm) on the cobalt-induced chronic epilepsy.Materials and methods. A model of cobalt-induced epilepsy was created by applying cobalt powder to the sensorimotor z
Externí odkaz:
https://doaj.org/article/f7b868130ad24aad93b438d3c08eef9c
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 40-45 (2017)
Using the multiparameter method of EEG analysis with a complex study of coherent interband links with topographic mapping and localization of equivalent dipole sources of individual EEG components, characteristic signs of changes in intercentral neur
Externí odkaz:
https://doaj.org/article/2671f8b81ed64bd080c82b2d0056fe1d
Autor:
I. O. Gaydukov, S. A. Litvinova, T. A. Voronina, L. N. Nerobkova, L. A. Zhmurenko, G. V. Mokrov, G. G. Avakyan, I. S. Kutepova
Publikováno v:
Эпилепсия и пароксизмальные состояния, Vol 9, Iss 2, Pp 57-66 (2017)
Objective of the research is to evaluate the anticonvulsant effect of the new original compound GIZH-298 (4-benzoylpyridine oxime derivative) versus valproic acid (VPA) in a model of epilepsy in rats with cobalt-induced lesions.Materials and methods.
Externí odkaz:
https://doaj.org/article/4ba1dec32ac242fba342a3a42170f35b
Autor:
L. A. Zhmurenko, G. V. Mokrov, L. N. Nerobkova, S. A. Litvinova, I. O. Gaydukov, T. A. Voronina, T. A. Gudasheva
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 22-26 (2017)
Novel derivative of benzoylpyridine oximes - GIZH-298 (4-benzoylpyridine 0-(2-morpholinoethyl) oxime oxalate) was designed and synthesized in this work. This compound has a broad spectrum of anticonvulsant effects, eliminating primary generalized sei
Externí odkaz:
https://doaj.org/article/7e930911f8374b798f0796275a46c084
Autor:
S. A. Litvinova, T. A. Voronina, V. S. Kudrin, I. O. Gaydukov, L. N. Nerobkova, M. B. Pisclova, G. G. Avakyan, L. А. Zhmurenko
Publikováno v:
Эпилепсия и пароксизмальные состояния, Vol 8, Iss 3, Pp 19-26 (2016)
The aim of this study was to investigate the electrophysiological and neurochemical mechanisms of the anticonvulsant effect of a new original compound GIZH-298 and to define the leading structure as the target for influence compound. Materials and Me
Externí odkaz:
https://doaj.org/article/cce4cd80ba204b99a9e970af5d264c5c
Autor:
G. N. Avakyan, O. L. Badalyan, S. G. Burd, Е. А. Valdman, Т. А. Voronina, L. N. Nerobkova, Е. V. Krikova, G. G. Аvakyan, A. S. Chukanova, M. I. Stoyko, А. А. Savenkov
Publikováno v:
Эпилепсия и пароксизмальные состояния, Vol 2, Iss 4, Pp 41-54 (2016)
This article reviews the issues of experimental and clinical epileptology. For the development and implementation of new medications and technologies of medicinal interventions, as well as investigation of main “targets” for anti-epileptic drugs,
Externí odkaz:
https://doaj.org/article/261de7fa607741d9b186e78a25bfd752
Publikováno v:
Эпилепсия и пароксизмальные состояния, Vol 3, Iss 2, Pp 34-44 (2016)
Possibilities of application the prolonged form valproic acid and antioxidant in secondary - generalized seizures was investigated in experiment and in clinical study in patients with epilepsy. In rats with cobalt-induced epilepsy their efficacy has
Externí odkaz:
https://doaj.org/article/d3a3756b2466486b831075069f37d92b
Autor:
Yu. B. Filatova, T. A. Voronina, G. N. Avakyan, L. N. Nerobkova, F. K. Rider, P. M. Klodt, V. S. Kudrin, G. G. Avakyan, I. A. Gaydukov
Publikováno v:
Эпилепсия и пароксизмальные состояния, Vol 4, Iss 1, Pp 29-33 (2016)
Rats with cobalt epilepsy in the estrous cycle revealed fluctuation of the levels of inhibitory neurotransmitters (especially GABA), but not of excitatory. The most significant changes were found out in the contralateral cortex, where the levels of G
Externí odkaz:
https://doaj.org/article/b5481af8b7f24763a2b467102aa674df