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Publikováno v:
Animal, Vol 8, Iss 12, Pp 1996-1998 (2014)
Toxoplasmosis is one of the five parasitic diseases considered as a priority for public health action. The consumption of raw milk products represents a possible risk, in particular for certain categories of people. The aim of this study was to evalu
Externí odkaz:
https://doaj.org/article/8c7557b3fe37441ca7e1abce76d7639d
Autor:
Luciana Marinelli, Concettina La Motta, L. Mugnaini, Michele Parrinello, Vittorio Limongelli, Stefania Sartini, Ettore Novellino, Federico Da Settimo, Sandro Cosconati
Publikováno v:
Proceedings of the National Academy of Sciences. 109:1467-1472
An exhaustive description of the molecular recognition mechanism between a ligand and its biological target is of great value because it provides the opportunity for an exogenous control of the related process. Very often this aim can be pursued usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11f0d0a9682d2e43ee29eeb1eeb38a2
https://doi.org/10.1073/pnas.1112181108
https://doi.org/10.1073/pnas.1112181108
Autor:
Teresa Di Desidero, Paola Orlandi, Anna Fioravanti, Bastianina Canu, Concettina La Motta, L. Mugnaini, Guido Bocci, Rita Frati, Paolo Miccoli, Sandro Cosconati, Piero Berti, Stefania Sartini, Romano Danesi, Federico Da Settimo, Alessandro Antonelli
Publikováno v:
Biochemical Pharmacology. 81:1309-1316
Aims: To demonstrate the antiproliferative and pro-apoptotic activity of the novel pyrazolopyrimidine derivative multiple tyrosine kinase inhibitor CLM3, alone and in combination with SN-38 (the active metabolite of irinotecan), on endothelial and tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ab37a43b2423e2514679078bc5a34c
https://doi.org/10.1016/j.bcp.2011.03.022
https://doi.org/10.1016/j.bcp.2011.03.022
Autor:
Concettina La Motta, Mario Del Tacca, Matteo Fornai, Francesca Simorini, Silvia Salerno, Antonio Lavecchia, Ettore Novellino, Sabrina Taliani, Federico Da Settimo, Anna Maria Marini, Corrado Blandizzi, Luca Antonioli, L. Mugnaini, Stefania Sartini
Publikováno v:
Journal of Medicinal Chemistry. 52:1681-1692
A number of pyrazolo[3,4-d]pyrimidin-4-ones bearing either alkyl or arylalkyl substituents in position 2 of the nucleus were synthesized and tested for their ability to inhibit adenosine deaminase (ADA) from bovine spleen. The 2-arylalkyl derivatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a461874e12305dd689a992587a3f94
https://doi.org/10.1021/jm801427r
https://doi.org/10.1021/jm801427r
Autor:
C. LA MOTTA, S. SARTINI, L. MUGNAINI, F. SIMORINI, S. TALIANI, S. SALERNO, A. M. MARINI, G. PRIMOFIORE, F. DA SETTIMO, LAVECCHIA, ANTONIO, NOVELLINO, ETTORE, M. CANTORE, P. FAILLI, M. CIUFFI
2-Phenyl-pyrido[1,2-a]pyrimidin-4-one derivatives bearing a phenol or a catechol moiety in position 2 were tested as aldose reductase (ALR2) inhibitors and exhibited activity levels in the micromolar/submicromolar range. Introduction of a hydroxy gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27da2ed585ca7a72f59c15482e9a7fd3
http://hdl.handle.net/11588/303940
http://hdl.handle.net/11588/303940
Autor:
L. Portalone, Anna Rita Cruciani, Franco Salvati, N Perrone, Francesco Nunziati, A. Lombardi, Antonio Antilli, V Magliacani, L Mugnaini, Mauro Signora
Publikováno v:
Tumori Journal. 85:239-242
Aims and Background The polychemotherapeutic regimen PEV (cisplatin, epidoxorubicin and vindesine) + lonidamine proved to be valid in terms of activity and efficacy in the treatment of patients with advanced, previously untreated non-small cell lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778ab94307205fabc81df1e1a7c225f3
https://doi.org/10.1177/030089169908500405
https://doi.org/10.1177/030089169908500405
Autor:
Rodríguez-Cattáneo, Alejo1 (AUTHOR), Pereira, Ana Carolina1 (AUTHOR), Aguilera, Pedro Anibal1 (AUTHOR), Caputi, Ángel Ariel1 (AUTHOR) caputiangel@gmail.com
Publikováno v:
PLoS ONE. 9/20/2024, Vol. 19 Issue 9, p1-33. 33p.
Autor:
Makhloufi, Hind1 (AUTHOR) hind.makhloufi@unilim.fr, Pinon, Aline1 (AUTHOR) aline.pinon@unilim.fr, Champavier, Yves2 (AUTHOR) yves.champavier@unilim.fr, Saliba, Jennifer3 (AUTHOR) jennifer.saliba@univ-lr.fr, Millot, Marion1 (AUTHOR) marion.millot@unilim.fr, Fruitier-Arnaudin, Ingrid3 (AUTHOR) ingrid.fruitier@univ-lr.fr, Liagre, Bertrand1 (AUTHOR) bertrand.liagre@unilim.fr, Chemin, Guillaume1 (AUTHOR) guillaume.chemin@unilim.fr, Mambu, Lengo1 (AUTHOR) lengo.mambu@unilim.fr
Publikováno v:
Molecules. Sep2024, Vol. 29 Issue 17, p4117. 17p.
Autor:
Luciana Marinelli, Concettina La Motta, Claudia Martini, Giovanni Greco, Sandro Cosconati, Federico Da Settimo, L. Mugnaini, Simona Daniele, Barbara Cosimelli, Anna Maria Marini, Silvia Salerno, Osele Ciampi, Francesca Simorini, Maria Letizia Trincavelli, Sabrina Taliani, Vittorio Limongelli, Ettore Novellino
Adenosine induces glioma cell proliferation by means of an antiapoptotic effect, which is blocked by cotreatment with selective A(3) AR antagonists. In this study, a novel series of N(2)-substituted pyrazolo[3,4-d]pyrimidines 2a-u was developed as hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb72f4d7d2e6e541f6d382d4ef56c07
http://hdl.handle.net/11568/141626
http://hdl.handle.net/11568/141626