Zobrazeno 1 - 10
of 724
pro vyhledávání: '"L Moldawer"'
Autor:
Evan L. Barrios, Leandro Balzano-Nogueira, Valerie E. Polcz, Christine Rodhouse, Jack R. Leary, Dijoia B. Darden, Jaimar C. Rincon, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Shawn D. Larson, Ashish Sharma, Gilburt Upchurch, Shannon M. Wallet, Todd M. Brusko, Tyler J. Loftus, Alicia M. Mohr, Robert Maile, Rhonda Bacher, Guoshuai Cai, Michael P. Kladde, Clayton E. Mathews, Lyle L. Moldawer, Maigan A. Brusko, Philip A. Efron
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionDespite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is a harbinger o
Externí odkaz:
https://doaj.org/article/e0557e75cb90464e859377a738355ef4
Autor:
Adam D. Price, Ellen R. Becker, Evan L. Barrios, Monty B. Mazer, Patrick W. McGonagill, Christian B. Bergmann, Michael D. Goodman, Robert W. Gould, Mahil Rao, Valerie E. Polcz, Tamara A. Kucaba, Andrew H. Walton, Sydney Miles, Julie Xu, Muxuan Liang, Tyler J. Loftus, Philip A. Efron, Kenneth E. Remy, Scott C. Brakenridge, Vladimir P. Badovinac, Thomas S. Griffith, Lyle L. Moldawer, Richard S. Hotchkiss, Charles C. Caldwell
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSepsis is a complex clinical syndrome characterized by a heterogenous host immune response. Historically, static protein and transcriptomic metrics have been employed to describe the underlying biology. Here, we tested the hypothesis that
Externí odkaz:
https://doaj.org/article/0d40c4cf70d04695a92503d2f0ae310b
Autor:
Evan L. Barrios, Jack R. Leary, Dijoia B. Darden, Jaimar C. Rincon, Micah Willis, Valerie E. Polcz, Gwendolyn S. Gillies, Jennifer A. Munley, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Marie-Pierre L. Gauthier, Shawn D. Larson, Laurence Morel, Tyler J. Loftus, Alicia M. Mohr, Robert Maile, Michael P. Kladde, Clayton E. Mathews, Maigan A. Brusko, Todd M. Brusko, Lyle L. Moldawer, Rhonda Bacher, Philip A. Efron
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSepsis engenders distinct host immunologic changes that include the expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role in tempering acute inflammatory responses but can persist in patients who devel
Externí odkaz:
https://doaj.org/article/c3d9f1e91fd841aa9fdb8d5f4c7a4bf1
Autor:
Jeremy A. Balch, Uan-I Chen, Oliver Liesenfeld, Petr Starostik, Tyler J. Loftus, Philip A. Efron, Scott C. Brakenridge, Timothy E. Sweeney, Lyle L. Moldawer
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may lead to targeted interventions. We investigated whether patients admit
Externí odkaz:
https://doaj.org/article/ebd16a5d714d405c8c683d468eb7bc5b
Autor:
Thomas Daix, Armelle Mathonnet, Scott Brakenridge, Pierre-François Dequin, Jean-Paul Mira, Frederique Berbille, Michel Morre, Robin Jeannet, Teresa Blood, Jacqueline Unsinger, Jane Blood, Andrew Walton, Lyle L. Moldawer, Richard Hotchkiss, Bruno François
Publikováno v:
Annals of Intensive Care, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Background Profound lymphopenia is an independent predictor of adverse clinical outcomes in sepsis. Interleukin-7 (IL-7) is essential for lymphocyte proliferation and survival. A previous phase II study showed that CYT107, a glycosylated rec
Externí odkaz:
https://doaj.org/article/ac01ea5bbb564dde939f73024683bed3
Autor:
Abigail S. Kane, Brittany P. Boribong, Maggie Loiselle, Anagha P. Chitnis, Hector Chavez, Lyle L. Moldawer, Shawn D. Larson, Oluwakemi Badaki-Makun, Daniel Irimia, Lael M. Yonker
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
IntroductionAlthough SARS-CoV-2 infection can lead to severe COVID-19 in children, the role of biomarkers for assessing the risk of progression to severe disease is not well established in the pediatric population. Given the differences in monocyte s
Externí odkaz:
https://doaj.org/article/adff15a0205f476ea30e631c6b47b95c
Autor:
Lael M. Yonker, Oluwakemi Badaki-Makun, Puneeta Arya, Brittany P. Boribong, Gabriela Moraru, Brittany Fenner, Jaimar Rincon, Alex Hopke, Brent Rogers, Jeremiah Hinson, Alessio Fasano, Lilly Lee, Sarah M. Kehoe, Shawn D. Larson, Hector Chavez, Scott Levin, Lyle L. Moldawer, Daniel Irimia
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening complication that can develop weeks to months after an initial SARS-CoV-2 infection. A complex, time-consuming laboratory evaluation is currently required
Externí odkaz:
https://doaj.org/article/5a4a0ff6f4bb4454aa1085ff72ab469c
Autor:
Lael M. Yonker, Oluwakemi Badaki-Makun, Puneeta Arya, Brittany P. Boribong, Gabriela Moraru, Brittany Fenner, Jaimar Rincon, Alex Hopke, Brent Rogers, Jeremiah Hinson, Alessio Fasano, Lilly Lee, Sarah M. Kehoe, Shawn D. Larson, Hector Chavez, Scott Levin, Lyle L. Moldawer, Daniel Irimia
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/f757014452bc4a26a43faac79f2412a2
Autor:
Michael C. Cox, Matthew Booth, Gabriela Ghita, Zhongkai Wang, Anna Gardner, Russell B. Hawkins, Dijoia B. Darden, Christiaan Leeuwenburgh, Lyle L. Moldawer, Frederick A. Moore, Philip A. Efron, Steven Anton, Scott C. Brakenridge
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 5, Pp 1203-1213 (2021)
Abstract Background Sarcopenia is a known risk factor for poor outcomes across many chronic diseases. The impact on outcomes of both pre‐existing sarcopenia and acute muscle wasting (AMW) in acute critical illness caused by sepsis remain unclear. M
Externí odkaz:
https://doaj.org/article/16684d1961b74cc18f2945b2599e2cd8
Autor:
Al Ozonoff, Joanna Schaenman, Naresh Doni Jayavelu, Carly E. Milliren, Carolyn S. Calfee, Charles B. Cairns, Monica Kraft, Lindsey R. Baden, Albert C. Shaw, Florian Krammer, Harm van Bakel, Denise A. Esserman, Shanshan Liu, Ana Fernandez Sesma, Viviana Simon, David A. Hafler, Ruth R. Montgomery, Steven H. Kleinstein, Ofer Levy, Christian Bime, Elias K. Haddad, David J. Erle, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Catherine L. Hough, William B. Messer, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Mark A. Atkinson, Scott C. Brakenridge, David Corry, Farrah Kheradmand, Lauren I.R. Ehrlich, Esther Melamed, Grace A. McComsey, Rafick Sekaly, Joann Diray-Arce, Bjoern Peters, Alison D. Augustine, Elaine F. Reed, Matthew C. Altman, Patrice M. Becker, Nadine Rouphael, Chris Bime, Mark M Davis, Kerry McEnaney, Brenda Barton, Claudia Lentucci, Mehmet Saluvan, Ana C. Chang, Annmarie Hoch, Marisa Albert, Tanzia Shaheen, Alvin T. Kho, Sanya Thomas, Jing Chen, Maimouna D. Murphy, Mitchell Cooney, Scott Presnell, Gabriela K. Fragiadakis, Ravi Patel, Leying Guan, Jeremy Gygi, Shrikant Pawar, Anderson Brito, Zain Khalil, Cole Maguire, Slim Fourati, James A. Overton, Randi Vita, Kerstin Westendorf, Ramin Salehi-Rad, Aleksandra Leligdowicz, Michael A. Matthay, Jonathan P. Singer, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Matthew F. Krummel, Charles R. Langelier, Prescott G. Woodruff, Debra L. Powell, James N. Kim, Brent Simmons, I. Michael Goonewardene, Cecilia M. Smith, Mark Martens, Jarrod Mosier, Hiroki Kimura, Amy C. Sherman, Stephen R. Walsh, Nicolas C. Issa, Charles Dela Cruz, Shelli Farhadian, Akiko Iwasaki, Albert I. Ko, Sharon Chinthrajah, Neera Ahuja, Angela J. Rogers, Maja Artandi, Sarah A.R. Siegel, Zhengchun Lu, Douglas A. Drevets, Brent R. Brown, Matthew L. Anderson, Faheem W. Guirgis, Rama V. Thyagarajan, Justin F. Rousseau, Dennis Wylie, Johanna Busch, Saurin Gandhi, Todd A. Triplett, George Yendewa, Olivia Giddings, Evan J. Anderson, Aneesh K. Mehta, Jonathan E. Sevransky, Bernard Khor, Adeeb Rahman, Daniel Stadlbauer, Jayeeta Dutta, Hui Xie, Seunghee Kim-Schulze, Ana Silvia Gonzalez-Reiche, Adriana van de Guchte, Keith Farrugia, Zenab Khan, Holden T. Maecker, David Elashoff, Jenny Brook, Estefania Ramires-Sanchez, Megan Llamas, Adreanne Rivera, Claudia Perdomo, Dawn C. Ward, Clara E. Magyar, Jennifer A. Fulcher, Yumiko Abe-Jones, Saurabh Asthana, Alexander Beagle, Sharvari Bhide, Sidney A. Carrillo, Suzanna Chak, Rajani Ghale, Ana Gonzalez, Alejandra Jauregui, Norman Jones, Tasha Lea, Deanna Lee, Raphael Lota, Jeff Milush, Viet Nguyen, Logan Pierce, Priya A. Prasad, Arjun Rao, Bushra Samad, Cole Shaw, Austin Sigman, Pratik Sinha, Alyssa Ward, Andrew Willmore, Jenny Zhan, Sadeed Rashid, Nicklaus Rodriguez, Kevin Tang, Luz Torres Altamirano, Legna Betancourt, Cindy Curiel, Nicole Sutter, Maria Tercero Paz, Gayelan Tietje-Ulrich, Carolyn Leroux, Jennifer Connors, Mariana Bernui, Michel A. Kutzler, Carolyn Edwards, Edward Lee, Edward Lin, Brett Croen, Nicholas C. Semenza, Brandon Rogowski, Nataliya Melnyk, Kyra Woloszczuk, Gina Cusimano, Mathew R. Bell, Sara Furukawa, Renee McLin, Pamela Marrero, Julie Sheidy, George P. Tegos, Crystal Nagle, Nathan Mege, Kristen Ulring, Vicki Seyfert-Margolis, Michelle Conway, Dave Francisco, Allyson Molzahn, Heidi Erickson, Connie Cathleen Wilson, Ron Schunk, Bianca Sierra, Trina Hughes, Kinga Smolen, Michael Desjardins, Simon van Haren, Xhoi Mitre, Jessica Cauley, Xiaofang Li, Alexandra Tong, Bethany Evans, Christina Montesano, Jose Humberto Licona, Jonathan Krauss, Jun Bai Park Chang, Natalie Izaguirre, Omkar Chaudhary, Andreas Coppi, John Fournier, Subhasis Mohanty, M. Catherine Muenker, Allison Nelson, Khadir Raddassi, Michael Rainone, William E. Ruff, Syim Salahuddin, Wade L. Schulz, Pavithra Vijayakumar, Haowei Wang, Elsio Wunder Jr., H. Patrick Young, Yujiao Zhao, Miti Saksena, Deena Altman, Erna Kojic, Komal Srivastava, Lily Q. Eaker, Maria C. Bermúdez-González, Katherine F. Beach, Levy A. Sominsky, Arman R. Azad, Juan Manuel Carreño, Gagandeep Singh, Ariel Raskin, Johnstone Tcheou, Dominika Bielak, Hisaaki Kawabata, Lubbertus CF Mulder, Giulio Kleiner, Alexandra S. Lee, Evan Do Do, Andrea Fernandes, Monali Manohar, Thomas Hagan, Catherine A. Blish, Hena Naz Din, Jonasel Roque, Samuel Yang, Amanda Brunton, Peter E. Sullivan, Matthew Strnad, Zoe L. Lyski, Felicity J. Coulter, J. Leland Booth, Lauren A. Sinko, Lyle L. Moldawer, Brittany Borresen, Brittney Roth-Manning, Li-Zhen Song, Ebony Nelson, Megan Lewis-Smith, Jacob Smith, Pablo Guaman Tipan, Nadia Siles, Sam Bazzi, Janelle Geltman, Kerin Hurley, Gio Gabriele, Scott Sieg, Tatyana Vaysman, Laurel Bristow, Laila Hussaini, Kieffer Hellmeister, Hady Samaha, Andrew Cheng, Christine Spainhour, Erin M. Scherer, Brandi Johnson, Amer Bechnak, Caroline R. Ciric, Lauren Hewitt, Erin Carter, Nina Mcnair, Bernadine Panganiban, Christopher Huerta, Jacob Usher, Susan Pereira Ribeiro
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104208- (2022)
Summary: Background: Better understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management. Methods: Immunophenotyping Assess
Externí odkaz:
https://doaj.org/article/6bb1f29e485b44e3b837f1d761005a73