Zobrazeno 1 - 10
of 95
pro vyhledávání: '"L Michel Espinoza-Fonseca"'
Autor:
M'Lynn E Fisher, Elisa Bovo, Rodrigo Aguayo-Ortiz, Ellen E Cho, Marsha P Pribadi, Michael P Dalton, Nishadh Rathod, M Joanne Lemieux, L Michel Espinoza-Fonseca, Seth L Robia, Aleksey V Zima, Howard S Young
Publikováno v:
eLife, Vol 10 (2021)
The sarco-plasmic reticulum calcium pump (SERCA) plays a critical role in the contraction-relaxation cycle of muscle. In cardiac muscle, SERCA is regulated by the inhibitor phospholamban. A new regulator, dwarf open reading frame (DWORF), has been re
Externí odkaz:
https://doaj.org/article/87991ab8aa184f75a15e117bb6842178
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95979 (2014)
We have performed microsecond molecular dynamics (MD) simulations to characterize the structural dynamics of cation-bound E1 intermediate states of the calcium pump (sarcoendoplasmic reticulum Ca²⁺-ATPase, SERCA) in atomic detail, including a lipi
Externí odkaz:
https://doaj.org/article/53d6a1c40bcf43eaa22cbda30dd081e1
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26936 (2011)
We have performed molecular dynamics (MD) simulations to elucidate, in atomic detail, the mechanism by which the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) is activated by Ca(2+). Crystal structures suggest that activation of SERCA occurs when the
Externí odkaz:
https://doaj.org/article/1cb699cbbdc644e4a2a79cb686268cf1
Autor:
Andy Y. Liu, Rodrigo Aguayo-Ortiz, Guadalupe Guerrero-Serna, Nulang Wang, Muriel G. Blin, Daniel R. Goldstein, L. Michel Espinoza-Fonseca
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 380-384 (2022)
Phospholamban (PLN) and Sarcolipin (SLN) are homologous membrane proteins that belong to the family of proteins that regulate the activity of the cardiac calcium pump (sarcoplasmic reticulum Ca2+-ATPase, SERCA). PLN and SLN share highly conserved leu
Externí odkaz:
https://doaj.org/article/9e4f8ec9e0414fe08348b6802eddd02a
Autor:
Rodrigo Aguayo-Ortiz, Jeffery Creech, Eric N. Jiménez-Vázquez, Guadalupe Guerrero-Serna, Nulang Wang, Andre Monteiro da Rocha, Todd J. Herron, L. Michel Espinoza-Fonseca
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Membrane proteins constitute a substantial fraction of the human proteome, thus representing a vast source of therapeutic drug targets. Indeed, newly devised technologies now allow targeting “undruggable” regions of membrane proteins to
Externí odkaz:
https://doaj.org/article/39ac1d8d1b97427ba94cce0ca3901e15
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 705-713 (2020)
Sarcoplasmic reticulum Ca2+ pump (SERCA) is a critical component of the Ca2+ transport machinery in myocytes. There is clear evidence for regulation of SERCA activity by PLB, whose activity is modulated by phosphorylation of its N-terminal domain (re
Externí odkaz:
https://doaj.org/article/72dd00a178e94cbab4530c66acc069cc
Autor:
Fernando D. Prieto-Martínez, Eli Fernández-de Gortari, José L. Medina-Franco, L. Michel Espinoza-Fonseca
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 1, Iss , Pp 100008- (2021)
The search for novel therapeutic compounds remains an overwhelming task owing to the time-consuming and expensive nature of the drug development process and low success rates. Traditional methodologies that rely on the one drug-one target paradigm ha
Externí odkaz:
https://doaj.org/article/5f42967b6e0e4dda984a99656771f947
Autor:
Andy Y. Liu, Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Publikováno v:
Biochemistry. 62:1331-1336
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d3f8238f1163f2b665995e520daaf7
https://doi.org/10.1021/acs.biochem.3c00026
https://doi.org/10.1021/acs.biochem.3c00026
Autor:
Jessi J. Bak, Rodrigo Aguayo-Ortiz, Nishadh Rathod, Joseph O. Primeau, Muhammad Bashir Khan, Seth L. Robia, M. Joanne Lemieux, L. Michel Espinoza-Fonseca, Howard S. Young
Publikováno v:
Biochemistry. 61(14)
Intracellular calcium signaling is essential for all kingdoms of life. An important part of this process is the sarco-endoplasmic reticulum Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783fcfd26cbc12e93be626753f4d66b9
https://pubmed.ncbi.nlm.nih.gov/35771007
https://pubmed.ncbi.nlm.nih.gov/35771007
Autor:
Carlos Cruz-Cortés, M. Andrés Velasco-Saavedra, Eli Fernández-de Gortari, Guadalupe Guerrero-Serna, Rodrigo Aguayo-Ortiz, L. Michel Espinoza-Fonseca
Publikováno v:
Journal of Biological Chemistry. 299:104681
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2e098efef6804f66236553b3c7dceb6
https://doi.org/10.1016/j.jbc.2023.104681
https://doi.org/10.1016/j.jbc.2023.104681