Zobrazeno 1 - 10
of 561
pro vyhledávání: '"L Merchant"'
Hepatic Proteomic Changes Associated with Liver Injury Caused by Alcohol Consumption in Fpr2−/− Mice
Autor:
Josiah E. Hardesty, Jeffrey B. Warner, Daniel W. Wilkey, Brett S. Phinney, Michelle R. Salemi, Michael L. Merchant, Craig J. McClain, Dennis R. Warner, Irina A. Kirpich
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9807 (2024)
Alcohol-associated liver disease (ALD) is a prevalent medical problem with limited effective treatment strategies. Although many biological processes contributing to ALD have been elucidated, a complete understanding of the underlying mechanisms is s
Externí odkaz:
https://doaj.org/article/3e9fdee8452a48648d33b270aaa38259
Autor:
Jiang Li, Toshifumi Sato, María Hernández-Tejero, Juliane I. Beier, Khaled Sayed, Panayiotis V. Benos, Daniel W. Wilkey, Abhinav Humar, Michael L. Merchant, Andres Duarte-Rojo, Gavin E. Arteel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Although liver transplantation (LT) is an effective therapy for cirrhosis, the risk of post-LT NASH is alarmingly high and is associated with accelerated progression to fibrosis/cirrhosis, cardiovascular disease and decreased survival. Lack
Externí odkaz:
https://doaj.org/article/abb9545801424a18bd94c2374937741d
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2985 (2024)
Gastrointestinal cancers represent one of the more challenging cancers to treat. Current strategies to cure and control gastrointestinal (GI) cancers like surgery, radiation, chemotherapy, and immunotherapy have met with limited success, and research
Externí odkaz:
https://doaj.org/article/0a18634aa0884098a6c1cb6036f4b6b8
Autor:
Heyu Song, Ricky A. Sontz, Matthew J. Vance, Julia M. Morris, Sulaiman Sheriff, Songli Zhu, Suzann Duan, Jiping Zeng, Erika Koeppe, Ritu Pandey, Curtis A. Thorne, Elena M. Stoffel, Juanita L. Merchant
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
The incidence of early-onset colorectal cancer (EO-CRC) is rising and is poorly understood. Lifestyle factors and altered genetic background possibly contribute. Here, we performed targeted exon sequencing of archived leukocyte DNA from 158 EO-CRC pa
Externí odkaz:
https://doaj.org/article/3c6bd39e8751433aa3ebb5c0d90e69a7
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMDSCs express SCHLAFEN 4 (SLFN4) in Helicobacter-infected stomachs coincident with spasmolytic polypeptide-expressing metaplasia (SPEM), a precursor of gastric cancer. We aimed to characterize SLFN4+ cell identity and the role of Slfn4 in
Externí odkaz:
https://doaj.org/article/464f3d13637c47969435bb16c4f247e4
Autor:
Soumya M. Turaga, Mihaela E. Sardiu, Vikalp Vishwakarma, Amrita Mitra, Leonidas E. Bantis, Rashna Madan, Michael L. Merchant, Jon B. Klein, Glenson Samuel, Andrew K. Godwin
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Ewing Sarcoma (EWS) is the second most common osseous malignancy in children and young adults after osteosarcoma, while it is the fifth common osseous malignancy within adult age population. The clinical presentation of EWS is quite often non-specifi
Externí odkaz:
https://doaj.org/article/4b02e8c5b1884a21aa60e87ca60f3fb2
Autor:
Mukesh K. Sriwastva, Yun Teng, Jingyao Mu, Fangyi Xu, Anil Kumar, Kumaran Sundaram, Rajiv Kumar Malhotra, Qingbo Xu, Joshua L. Hood, Lifeng Zhang, Jun Yan, Michael L. Merchant, Juw Won Park, Gerald W. Dryden, Nejat K. Egilmez, Huang‐Ge Zhang
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 2, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EVs) contain more than 100 proteins. Whether there are EVs proteins that act as an ‘organiser’ of protein networks to generate a new or different biological effect from that identified in EV‐producing cells has
Externí odkaz:
https://doaj.org/article/33c5cd4cf6cb4bf493fc823ff60c3791
Autor:
Toshifumi Sato, Kimberly Z. Head, Jiang Li, Christine E. Dolin, Daniel Wilkey, Nolan Skirtich, Katelyn Smith, Dylan D. McCreary, Sylvia Liu, Juliane I. Beier, Aatur D. Singhi, Ryan M. McEnaney, Michael L. Merchant, Gavin E. Arteel
Publikováno v:
Matrix Biology Plus, Vol 17, Iss , Pp 100127- (2023)
Although most work has focused on resolution of collagen ECM, fibrosis resolution involves changes to several ECM proteins. The purpose of the current study was twofold: 1) to examine the role of MMP12 and elastin; and 2) to investigate the changes i
Externí odkaz:
https://doaj.org/article/b4a3e19f54cd4396a9a5f48571ac9871
Autor:
Farhad Shiri, Haidong Feng, Kevin E. Petersen, Himanshu Sant, Gina T. Bardi, Luke A. Schroeder, Michael L. Merchant, Bruce K. Gale, Joshua L. Hood
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Nanoscale and microscale cell-derived extracellular vesicle types and subtypes are of significant interest to researchers in biology and medicine. Extracellular vesicles (EVs) have diagnostic and therapeutic potential in terms of biomarker a
Externí odkaz:
https://doaj.org/article/d8371ee0d24a4522898b1b552f370a59
Autor:
Kyung U. Hong, Jonathan Q. Gardner, Mark A. Doll, Marcus W. Stepp, Daniel W. Wilkey, Frederick W. Benz, Jian Cai, Michael L. Merchant, David W. Hein
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1566-1573 (2022)
Previous studies have shown that inhibition or depletion of N-acetyltransferase 1 (NAT1) in breast cancer cell lines leads to growth retardation both in vitro and in vivo, suggesting that NAT1 contributes to rapid growth of breast cancer cells. To un
Externí odkaz:
https://doaj.org/article/14d38dbd1a6144afb9a6d281a22dfd77