Zobrazeno 1 - 10
of 150
pro vyhledávání: '"L McKinzie"'
Autor:
Tong Wu, Louis M. Pelus, P. Artur Plett, Carol H. Sampson, Hui Lin Chua, Alexa Fisher, Hailin Feng, Liqiong Liu, Hongge Li, Miguel Ortiz, Supriya Chittajallu, Qianyi Luo, Ashay D. Bhatwadekar, Timothy B. Meyer, Xin Zhang, Daohong Zhou, Kathryn D. Fischer, David L. McKinzie, Steven J. Miller, Christie M. Orschell
Publikováno v:
Radiation Research. 199
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0ed66f789502c4c668a5378389a4b49
https://doi.org/10.1667/rade-22-00208.1
https://doi.org/10.1667/rade-22-00208.1
Autor:
Xavier Taylor, Abigail Perkins, Nur Jury, Cristian A. Lasagna-Reeves, Henika Patel, Pablo Martinez, David L. McKinzie
Publikováno v:
Neurobiol Aging
Pathological aggregation of tau and neuroinflammatory changes mark the clinical course of Alzheimer's disease and related tauopathies. To understand the correlation between these pathological hallmarks and functional deficits, we assessed behavioral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6303c4627297cef0c2c2957c3c543a
https://doi.org/10.1016/j.neurobiolaging.2021.09.006
https://doi.org/10.1016/j.neurobiolaging.2021.09.006
Autor:
Pablo Martinez, Henika Patel, Yanwen You, Nur Jury, Abigail Perkins, Audrey Lee-Gosselin, Xavier Taylor, Yingjian You, Gonzalo Viana Di Prisco, Xiaoqing Huang, Sayan Dutta, Aruna B. Wijeratne, Javier Redding-Ochoa, Syed Salman Shahid, Juan F. Codocedo, Sehong Min, Gary E. Landreth, Amber L. Mosley, Yu-Chien Wu, David L. McKinzie, Jean-Christophe Rochet, Jie Zhang, Brady K. Atwood, Juan Troncoso, Cristian A. Lasagna-Reeves
Publikováno v:
Nature neuroscience. 25(12)
Tau aggregation is a defining histopathological feature of Alzheimer’s disease and other tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear. Here, we performed an unbiased quantitative proteomic study to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ab07adc7639f434e9c31dd767023b0
https://pubmed.ncbi.nlm.nih.gov/36344699
https://pubmed.ncbi.nlm.nih.gov/36344699
Autor:
Brian A. Willis, Stephen L. Lowe, Scott A. Monk, Patrick J. Cocke, Christopher D. Aluise, Leonard N. Boggs, Anthony R. Borders, Richard A. Brier, Robert A. Dean, Steven J. Green, Douglas E. James, Stanford S. Jhee, Qun Lin, Albert C. Lo, Patrick C. May, Brian M. Watson, Leonard L. Winneroski, Zhixiang Yang, Jennifer A. Zimmer, David L. McKinzie, Dustin J. Mergott
Publikováno v:
Journal of Alzheimer's disease reports. 6(1)
Background: The development of beta-site amyloid-beta precursor protein cleaving enzyme (BACE) 1 inhibitors for the treatment of Alzheimer’s disease requires optimization of inhibitor potency, selectivity, and brain penetration. Moreover, there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912368ce5d97e52cb749b71026a53952
https://pubmed.ncbi.nlm.nih.gov/35243208
https://pubmed.ncbi.nlm.nih.gov/35243208
Autor:
O. El Jordi, P. Niziolek, David L. McKinzie, N. Holguin, Alycia G. Berman, N. Bhadouria, Joseph M. Wallace
Estrogen agonist raloxifene is an FDA-approved treatment for osteoporosis in postmenopausal women that may also be a promising prophylactic for painful intervertebral disc (IVD) degeneration. Here, we hypothesized that raloxifene would augment IVD st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eb759d66ffbde6049e4db47651974e0
https://doi.org/10.1101/2021.06.29.449482
https://doi.org/10.1101/2021.06.29.449482
Autor:
Stephanie L. Stout, Leonard L. Winneroski, Jorg Hendle, Warren J. Porter, Patrick J. C. May, Leonard N. Boggs, Thomas K. Baker, James P. Beck, Steven James Green, Anthony R. Borders, Erik James Hembre, Stephen L. Lowe, Christopher D Aluise, David L. McKinzie, Brian Morgan Watson, Brian Michael Mathes, Jon A. Erickson, Zhixiang Yang, Patrick J Cocke, Dustin J. Mergott, Brian A. Willis, Scott A. Monk, Pablo Garcia-Losada, David E. Timm, Richard A. Brier, Jose Eduardo Lopez
Publikováno v:
Journal of medicinal chemistry. 64(12)
The beta-site APP cleaving enzyme 1, known as BACE1, has been a widely pursued Alzheimer's disease drug target owing to its critical role in the production of amyloid-beta. We have previously reported the clinical development of LY2811376 and LY28867
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698057ee408d2f35c662510d099e51b3
https://pubmed.ncbi.nlm.nih.gov/34081466
https://pubmed.ncbi.nlm.nih.gov/34081466
Autor:
David L. McKinzie, Christian C. Felder, Kathryn Fischer, Timothy Meyer, Samantha E. Yohn, Michael Popiolek, Steven M. Paul
Publikováno v:
Biological Psychiatry. 91:S332
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::117b942d7320917d795693e0d03ccfd4
https://doi.org/10.1016/j.biopsych.2022.02.836
https://doi.org/10.1016/j.biopsych.2022.02.836
Autor:
Alberto Galbusera, Gary Gilmour, Carola Canella, David B. Shaw, Andrew McCarthy, Daniel Gutierrez-Barragan, Keith A. Wafford, Christian C. Felder, Alessandro Gozzi, David L. McKinzie, Adam J. Schwarz, Caterina Montani, Karen M. Knitowski, Jennifer Li
Publikováno v:
Neuropsychopharmacology
Cholinergic drugs acting at M1/M4 muscarinic receptors hold promise for the treatment of symptoms associated with brain disorders characterized by cognitive impairment, mood disturbances, or psychosis, such as Alzheimer's disease or schizophrenia. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ef9942a3f22055f767f8435ac9b60e
https://pubmed.ncbi.nlm.nih.gov/33342996
https://pubmed.ncbi.nlm.nih.gov/33342996
Autor:
Gary Gilmour, Alberto Galbusera, Andrew McCarthy, David L. McKinzie, Adam J. Schwarz, Jennifer Li, Keith A. Wafford, Christian C. Felder, Carola Canella, Karen M. Knitowski, Alessandro Gozzi, David B. Shaw, Caterina Montani
Cholinergic drugs acting at M1/M4 muscarinic receptors hold promise for the treatment of symptoms associated with brain disorders characterized by cognitive impairment, mood disturbances or psychosis, such as Alzheimer’s disease or schizophrenia. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8436f95b1e8842ebed711e47c006fc5e
Autor:
Frances Lu, Bryan G. Johnson, Daniel Ursu, Joan H. Carter, Lisa M. Broad, Kofi Adragni, Shane Atwell, Jing Wang, David K. Clawson, Beverly A. Heinz, Steven P. Swanson, James A. Monn, Qi Chen, Helene E. Sanger, David B. Shaw, Steven Marc Massey, Xushan Wang, Marijane Russell, Steven S. Henry, Junliang Hao, Rajni M. Bhardwaj, Diseroad Benjamin Alan, David L. McKinzie, Brian G. Getman, John T. Catlow
Publikováno v:
Journal of Medicinal Chemistry. 61:2303-2328
Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu3) receptors, but small molecule tools are lacking. As part of our ongoing efforts to identify potent, selective, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34fd3a986aac486e41e6ea738f1a4465
https://doi.org/10.1021/acs.jmedchem.7b01481
https://doi.org/10.1021/acs.jmedchem.7b01481