Zobrazeno 1 - 10
of 35
pro vyhledávání: '"L M Secker-Walker"'
Autor:
F Wright, Butler T, E Massey, Andres Virchis, P Devaraj, L. M. Secker-Walker, H. G. Prentice, Atul Mehta
Publikováno v:
British Journal of Haematology. 114:551-556
Demonstration of either the translocation t(15;17)(q22;q21) or the fusion of PML and RARalpha genes is regarded as diagnostic for acute myeloid leukaemia (AML) of FAB type M3, but has occasionally been seen in other FAB types. We present two such cas
Autor:
Osborn B. Eden, C. F. Bennett, Ah Goldstone, L M Secker-Walker, Christine J. Harrison, Anthony V. Moorman, Susan M. Richards, M Martineau, K Roberts, R Clark, S.A. Byatt, M Brama
Publikováno v:
Scopus-Elsevier
Twenty new cases of acute lymphoblastic leukemia (ALL) with the dicentric chromosome dic(9;20)(p1113;q11) are presented. This chromosomal abnormality is difficult to identify from G-banding alone. It masquerades as monosomy 20 and is only accurately
Publikováno v:
British journal of haematology. 101(4)
We retrospectively report data on 28 patients with haematological malignancy and trisomy 13 (25 cases) or tetrasomy 13 (three cases) as the primary acquired cytogenetic change. Peripheral blood and/or bone marrow morphology was reviewed in 25/28 case
Publikováno v:
Leukemia. 12(5)
Balanced translocations of 11q23 are associated with specific clinical features and a poor outcome, but the relevance of deletions involving 11q23 is not clear. Fifty-seven patients with this deletion were collected by the Workshop, 30 had terminal a
Autor:
B, Johansson, A V, Moorman, O A, Haas, A E, Watmore, K L, Cheung, S, Swanton, L M, Secker-Walker
Publikováno v:
Leukemia. 12(5)
A total of 183 hematologic malignancies with t(4;11)(q21;q23), including five variant translocations, were collected by the Workshop. Clinical, morphologic and immunophenotypic features were compiled, and karyotypes with variant t(4;11) or secondary
Publikováno v:
Leukemia. 12(5)
Most hematological neoplasms associated with 11q23 chromosomal rearrangement have been cases of acute lymphoblastic or acute myeloid leukemia. Although cases of myelodysplastic syndrome (MDS) are a minority, these syndromes should also be recognized
Publikováno v:
Leukemia. 12(5)
Forty of the 550 patients (7%) entered to the 11q23 Workshop had secondary (s) acute lymphoblastic leukemia (nine cases), s-acute myeloid leukemia (25 cases, predominantly of FAB type M5), s-acute leukemia unspecified (one case) or s-myelodysplastic
Publikováno v:
Leukemia. 12(5)
Cytogenetic and molecular analyses of 11q23/MLL positive hematologic malignancies show that der(11) encodes the critical 5'MLL/3'partner gene transcript. The role of der(non-11) bearing the 5'partner/3'MLL fusion is less certain. The cytogenetic evid
Autor:
C J, Harrison, A, Cuneo, R, Clark, B, Johansson, M, Lafage-Pochitaloff, F, Mugneret, A V, Moorman, L M, Secker-Walker
Publikováno v:
Leukemia. 12(5)
The MLL gene located at 11q23 has been described as a 'promiscuous' gene due its involvement with a large number of genetic partners. The EU Concerted Action Workshop on 11q23 provided 550 cases for study of which 82 showed abnormalities which did no
Publikováno v:
Leukemia. 12(5)
This paper reports clinical and cytogenetic data from 125 cases with t(9;11)(p21-22;q32) which were accepted for a European Union Concerted Action Workshop on 11q23. This chromosome abnormality is known to occur predominantly in acute myeloid leukemi