Zobrazeno 1 - 7
of 7
pro vyhledávání: '"L M Papp"'
Autor:
Patten Arthur David, R. J. Page, Margaret P. Stafford, R. J. Mcripley, M. R. Kirshenbaum, P. M. Czerniak, Robert J. Cherney, E. Akamike, Robert F. Kaltenbach, Mike Vavala, Zelleka Getahun, Steven P. Seitz, George L. Trainor, Stephen G. Swartz, Janet L. Gross, L. M. Papp, R. J. Diamond, Jung-Hui Sun, Carl Henry Behrens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:163-168
Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaeac0370b60b43a7b682aae544d033d
https://doi.org/10.1016/s0960-894x(96)00591-4
https://doi.org/10.1016/s0960-894x(96)00591-4
Autor:
Steven P. Seitz, M. R. Kirshenbaum, L. M. Papp, R. J. Page, Janet L. Gross, Margaret P. Stafford, R. J. Mcripley, Patten Arthur David, Stephen G. Swartz, Zelleka Getahun, George L. Trainor, E. Akamike, Robert F. Kaltenbach, P. M. Czerniak, R. J. Diamond, Jung-Hui Sun, Carl Henry Behrens, Robert J. Cherney, Mike Vavala
Publikováno v:
ChemInform. 28
Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::694fb7e2b37e36977a8dd476c2846823
https://doi.org/10.1002/chin.199720133
https://doi.org/10.1002/chin.199720133
Autor:
R. J. Ardecky, D. P. Hesson, G. V. Rao, M. Forbes, Daniel L. Dexter, Shih-Fong Chen, L. M. Papp
Publikováno v:
Biochemical Pharmacology. 40:709-714
The novel anticancer drug candidate brequinar sodium [DuP 785, NSC 368390, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid sodium salt] inhibits dihydroorotate dehydrogenase, the fourth enzyme in the de novo pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead0bd6f642f38eed03b609e71a97c9c
https://doi.org/10.1016/0006-2952(90)90305-5
https://doi.org/10.1016/0006-2952(90)90305-5
Autor:
M R, Kirshenbaum, S F, Chen, C H, Behrens, L M, Papp, M M, Stafford, J H, Sun, D L, Behrens, J R, Fredericks, S T, Polkus, P, Sipple
Publikováno v:
Cancer research. 54(8)
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), is a bis-naphthalimide anticancer tumoricidal agent currently in phase I clinical trials. DMP 840 exhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5785474fb053240e6ca33b5f83dd136
https://pubmed.ncbi.nlm.nih.gov/8174127
https://pubmed.ncbi.nlm.nih.gov/8174127
Autor:
S F Chen, D L Behrens, C H Behrens, P M Czerniak, D L Dexter, B L Dusak, J R Fredericks, K C Gale, J L Gross, J B Jiang, Kirshenbau m, R J McRipley, L M Papp, A D Patten, F W Perrella, S P Seitz, M P Stafford, J H Sun, T Sun, M A Wuonola, DD Von Hoff
Publikováno v:
Anti-cancer drugs. 4(4)
We have synthesized a promising class of bis-naphthalimide anti-tumor agents. A representative compound in this series, XB596, exhibits potent in vitro growth inhibitory activity against several human and murine leukemic and solid tumor lines in cult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb58de8f69e772c79e589276766e0556
https://pubmed.ncbi.nlm.nih.gov/8400347
https://pubmed.ncbi.nlm.nih.gov/8400347
Publikováno v:
Cancer research. 52(13)
The novel anticancer drug candidate brequinar sodium (DuP 785, NSC 368390, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline- carboxylic acid sodium salt) was shown previously to be an inhibitor of dihydroorotate dehydrogenase, the fourt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c804cce2363f5d5c52d3eadcf3a3141c
https://pubmed.ncbi.nlm.nih.gov/1617622
https://pubmed.ncbi.nlm.nih.gov/1617622
Publikováno v:
Biochemical pharmacology. 40(4)
The novel anticancer drug candidate brequinar sodium [DuP 785, NSC 368390, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid sodium salt] inhibits dihydroorotate dehydrogenase, the fourth enzyme in the de novo pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0801d6749c1bbdae4d6d9122ade786aa
https://pubmed.ncbi.nlm.nih.gov/2386542
https://pubmed.ncbi.nlm.nih.gov/2386542