Zobrazeno 1 - 10
of 84
pro vyhledávání: '"L M Golub"'
Publikováno v:
Journal of periodontology. 56
Defects in neutrophil or polymorphonuclear leukocyte (PMNL) chemotaxis have been observed in a number of clinical conditions, including Down's syndrome and insulin-dependent diabetes mellitus (IDDM), which tend to be associated with severe forms of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fecb44af289b3a69b2ad73598cd0b8
https://pubmed.ncbi.nlm.nih.gov/29538942
https://pubmed.ncbi.nlm.nih.gov/29538942
Autor:
Hsi-Ming Lee, Francis Johnson, D. D. Moore, Muna S. Elburki, L. M. Golub, Yazhou Zhang, N. G. Terezakis
Publikováno v:
Journal of periodontal research. 52(2)
Background and Objective Periodontal disease is the most common chronic inflammatory disease known to mankind (and the major cause of tooth loss in the adult population) and has also been linked to various systemic diseases, particularly diabetes mel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9088c7de1074e038c6b71b866aaf82c9
https://pubmed.ncbi.nlm.nih.gov/27038334
https://pubmed.ncbi.nlm.nih.gov/27038334
Autor:
L. M. Golub, Dr.D. Grenier, Thomas F. Mcnamara, H-M. Lee, Denis Mayrand, N. S. Ramamurthy, Pascale Plamondon, Timo Sorsa, Olli Teronen
Publikováno v:
Journal of Periodontology. 73:79-85
Tetracyclines, particularly doxycycline (Doxy), and their non-antimicrobial chemically-modified derivatives (CMTs) inhibit the activities of human matrix metalloproteinases (MMPs), and reduce the severity and progression of periodontal disease in ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db84bd15c1f8338c869a4fec12693be0
https://doi.org/10.1902/jop.2002.73.1.79
https://doi.org/10.1902/jop.2002.73.1.79
Publikováno v:
Current Medicinal Chemistry. 8:253-256
CMT-3 is a NON-ANTIMICROBIAL tetracycline (TC), chemically modified to enhance its collagenase-inhibitory property. This property is therapeutically useful in treating diseases such as periodontitis, cancer and arthritis. CMT-3 was labeled with triti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3994681ada875373fa89ca28c5cd1e8b
https://doi.org/10.2174/0929867013373615
https://doi.org/10.2174/0929867013373615
Publikováno v:
Advances in Dental Research. 12:144-148
Delayed wound healing is one of the complications of diabetes mellitus, exhibited by increased wound collagenase and decreased granulation tissues. The current study compared wound healing in normal and diabetic rats, and the effects of topically app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1462f5f7f74b210bc53ed058eb9d816d
https://doi.org/10.1177/08959374980120011001
https://doi.org/10.1177/08959374980120011001
Publikováno v:
Advances in Dental Research. 12:152-158
Glycation of proteins, which is accelerated in the diabetic state, has been implicated in many of the long-term complications of diabetes. This process can be inhibited by members of the tetracycline family of compounds. This novel finding is support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0667636afcbd4990b5dca14e41b961
https://doi.org/10.1177/08959374980120011201
https://doi.org/10.1177/08959374980120011201
Autor:
Richard T. Evans, L. M. Golub, K.L. Schroeder, C. Bosko, McNamara Tf, A.J. Gwinnett, N. S. Ramamurthy
Publikováno v:
Advances in Dental Research. 12:43-50
The incidence of root caries has been found to increase as the population ages and as edentulism becomes less prevalent due to improved dental awareness and care, and as exposure of roots due to gingival recession has also increased in the elderly. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b42c95eb58815d7ea18f3f4240945c
https://doi.org/10.1177/08959374980120011801
https://doi.org/10.1177/08959374980120011801
Autor:
J. Leferson, T. F. Mcnamara, Mary J.C. Hendrix, E. A. Seftor, William G. Stetler-Stevenson, L. M. Golub, Richard E.B. Seftor, David E. Kleiner, J. E. De Larco
Publikováno v:
Clinical and Experimental Metastasis. 16:217-225
Recent work has shown that chemically modified tetracyclines (CMTs) are potent inhibitors of matrix metal-loproteinase (MMP) activity, both in vitro and in vivo, which is distinct from their antimicrobial activities (Golub et al. Crit Rev Oral Biol M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c38812f6589008c2dc4ea70011fa780
https://doi.org/10.1023/a:1006588708131
https://doi.org/10.1023/a:1006588708131
Publikováno v:
Bone. 21:147-153
The skeletal consequences of streptozotocin-induced (STZ) diabetes in the rat are characterized by decreased bone formation and, consequently, reductions in bone mass. Given the ability of tetracyclines to inhibit the breakdown of connective tissue c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a33cc68b7ceb13c07a7f4758d6d9d9f
https://doi.org/10.1016/s8756-3282(97)00104-x
https://doi.org/10.1016/s8756-3282(97)00104-x
Publikováno v:
Technology and Health Care. 4:311-316
The authors, including an academic-inventor, the director of the University's tech-transfer office, and the CEO of a "start-up" pharmaceutical company based on the professor's (and his colleague's) inventions, relate the history and current status of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cbb51c3c79f35b19cdac5fbf0e4cee5
https://doi.org/10.3233/thc-1996-4309
https://doi.org/10.3233/thc-1996-4309