Zobrazeno 1 - 10
of 32
pro vyhledávání: '"L M, Wakefield"'
Publikováno v:
Cytokine Growth Factor Rev
With the development of growth factors and growth factor modulators as therapeutics for a range of disorders, it is prudent to consider whether modulating the growth factor profile in a tissue can influence tumour initiation or progression. As recomb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962f392175bd7573e14c883c5f675c8c
https://europepmc.org/articles/PMC7294566/
https://europepmc.org/articles/PMC7294566/
Autor:
F. V. Howell, David Danielpour, K. E P Van Roozendaal, S. R. Ebbs, M. Baum, Anthony A. Colletta, L. M. Wakefield, M. B. Sporn
Publikováno v:
British Journal of Cancer
The clinical use of anti-oestrogens in breast cancer therapy has traditionally been restricted to tumours that contain measurable oestrogen receptor protein. However, it is now widely recognised that the clinical response to adjuvant anti-oestrogen t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffda3b8dc0a9b9b733a710d0e304091
https://doi.org/10.1038/bjc.1990.307
https://doi.org/10.1038/bjc.1990.307
Publikováno v:
Journal of mammary gland biology and neoplasia. 6(1)
Ligands of the TGF-beta superfamily are unique in that they signal through transmembrane receptor serine-threonine kinases, rather than tyrosine kinases. The receptor complex couples to a signal transduction pathway involving a novel family of protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb5242eb5b02dae04f813e6609c676ea
https://pubmed.ncbi.nlm.nih.gov/11467453
https://pubmed.ncbi.nlm.nih.gov/11467453
Publikováno v:
Molecular carcinogenesis. 29(2)
To elucidate the role of transforming growth factor-beta1 (TGF-beta1) and the TGF-beta type II receptor (TGF-beta RII) as tumor-suppressor genes in lung carcinogenesis, we mated C57BL/6 mice heterozygous (HT) for deletion of the TGF-beta1 gene with A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::080ef907576b99c270ec322009d7430e
https://pubmed.ncbi.nlm.nih.gov/11074608
https://pubmed.ncbi.nlm.nih.gov/11074608
Autor:
B, Tang, K, de Castro, H E, Barnes, W T, Parks, L, Stewart, E P, Böttinger, D, Danielpour, L M, Wakefield
Publikováno v:
Cancer research. 59(19)
Transforming growth factor (TGF)-betas are multifunctional growth factors, the properties of which include the potent inhibition of epithelial cell growth. Expression patterns of TGF-betas and TGF-beta receptors in the normal prostate indicate that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0d2e1740d6d361651ed164d597b6eaf
https://pubmed.ncbi.nlm.nih.gov/10519393
https://pubmed.ncbi.nlm.nih.gov/10519393
Publikováno v:
Cancer research. 57(24)
To test the hypothesis that the transforming growth factor-beta (TGF-beta) system has tumor suppressor activity in the mammary gland, we have generated transgenic mice overexpressing a dominant-negative mutant form of the type II TGF-beta receptor, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6027b0eb43dbb8692cc82e5736e856c
https://pubmed.ncbi.nlm.nih.gov/9407968
https://pubmed.ncbi.nlm.nih.gov/9407968
Autor:
L M, Wakefield, J J, Letterio, A G, Geiser, K C, Flanders, J, O'Shaughnessy, A B, Roberts, M B, Sporn
Publikováno v:
Progress in clinical and biological research. 391
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17910eb27967c77dd74582402a742b57
https://pubmed.ncbi.nlm.nih.gov/8532712
https://pubmed.ncbi.nlm.nih.gov/8532712
Autor:
L M, Wakefield, J J, Letterio, T, Chen, D, Danielpour, R S, Allison, L H, Pai, A M, Denicoff, M H, Noone, K H, Cowan, J A, O'Shaughnessy
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 1(1)
A method has been developed to determine true plasma transforming growth factor beta (TGF-beta) levels by using the platelet alpha granule-specific marker, platelet factor 4, to correct for the TGF-beta contributed by platelets degranulated ex vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04f070c743f5f1cce1b7a729970902da
https://pubmed.ncbi.nlm.nih.gov/9815895
https://pubmed.ncbi.nlm.nih.gov/9815895
Autor:
A, Butta, K, MacLennan, K C, Flanders, N P, Sacks, I, Smith, A, McKinna, M, Dowsett, L M, Wakefield, M B, Sporn, M, Baum
Publikováno v:
Cancer research. 52(15)
We have investigated the ability of tamoxifen to regulate members of the transforming growth factor beta (TGF-beta) family in human breast cancers in vivo. Using immunohistochemical techniques, we find that 3 months of tamoxifen treatment causes a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dcc7c66522d63096d0b3f46c64b08ee0
https://pubmed.ncbi.nlm.nih.gov/1322240
https://pubmed.ncbi.nlm.nih.gov/1322240
Publikováno v:
The Journal of biological chemistry. 267(19)
Since many lines of evidence suggest that expression of the transforming growth factor-beta 1 (TGF-beta 1) gene may be regulated post-transcriptionally, we examined the effect of the 5'-untranslated region (UTR) of this gene on TGF-beta 1 expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9da8fccf5b7039c0e7f70980375359d2
https://pubmed.ncbi.nlm.nih.gov/1618868
https://pubmed.ncbi.nlm.nih.gov/1618868