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Evidence for the lack of base-change and small-deletion mutation induction by trichloroethylene in lacZ transgenic mice

Autor: G R, Douglas, J D, Gingerich, L M, Soper, M, Potvin, S, Bjarnason

Publikováno v: Environmental and molecular mutagenesis. 34(2-3)

Trichloroethylene (TCE) is a widely used industrial solvent employed mainly for degreasing and cold-cleaning metal parts. It is also used for dry cleaning, and in the production of a number of chemical products. It has been shown to induce liver and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56263d22c9e12e81bc0a2697cf6999a3
https://pubmed.ncbi.nlm.nih.gov/10529743

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Temporal and molecular characteristics of lacZ mutations in somatic tissues of transgenic mice

Autor: G R, Douglas, J, Jiao, J D, Gingerich, L M, Soper, J A, Gossen

Publikováno v: Environmental and molecular mutagenesis. 28(4)

In order to help establish criteria for optimizing protocols for in vivo mutation studies, lacZ transgenic mice (Muta mouse) were treated with five consecutive daily doses of ethylnitrosourea (50 mg/kg), sampled at times up to 55 days after treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3224328d9ce267236c6f65e9244f2b9a
https://pubmed.ncbi.nlm.nih.gov/8991059

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