Zobrazeno 1 - 8
of 8
pro vyhledávání: '"L M, Pullan"'
Publikováno v:
Journal of Neural Transmission. 97:175-185
It was shown in the present study that several structurally diverse antagonists of the glycine site of the NMDA receptor, including (R)-HA-966, L 689,560, 5,7-dichlorokynurenic acid, 7-chlorokynurenic acid, and two of ZENECA's novel pyridazinoindole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d243779fc6d57d46dd1cbd1b1bcdc5e
https://doi.org/10.1007/bf02336139
https://doi.org/10.1007/bf02336139
Autor:
L M, Pullan, R J, Powel
Publikováno v:
Neuroscience letters. 148(1-2)
We compared, for a number of ligands to the two receptors, the displacement of [3H]strychnine binding to the glycine-gated chloride channel of spinal cord and brainstem synaptic membranes to the displacement of [3H]glycine binding to the NMDA recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a07bf5848dbe2e9bb110b3f34527c2d
https://pubmed.ncbi.nlm.nih.gov/1338650
https://pubmed.ncbi.nlm.nih.gov/1338650
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(2)
The effects of N-(3-aminopropyl)-1,10-diaminodecane (APDA10) on the N-methyl-D-aspartate (NMDA) receptor/ion channel complex were investigated. In the presence of 100 microM glutamate and 100 microM glycine, APDA10 had biphasic effects on the binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b51717b7ac837d1910415da86a3e6f9
https://pubmed.ncbi.nlm.nih.gov/1354252
https://pubmed.ncbi.nlm.nih.gov/1354252
Autor:
L M, Pullan, M, Britt, M J, Chapdelaine, R A, Keith, D, LaMonte, T J, Mangano, J, Patel, R J, Powel, R J, Stumpo, P J, Warwick
Publikováno v:
Journal of neurochemistry. 55(4)
HA-966 (1-hydroxy-3-aminopyrrolidone-2) is an antagonist at the glycine allosteric site of the N-methyl-D-aspartate receptor ionophore complex. Unlike presently known glycine antagonists, HA-966 is chiral. We report stereoselectivity for the (R)-enan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4e6ded9c6b7a8268e4d98a3736b1c6e
https://pubmed.ncbi.nlm.nih.gov/1975835
https://pubmed.ncbi.nlm.nih.gov/1975835
Autor:
L. M. Pullan
Publikováno v:
Amino Acids ISBN: 9789072199041
N-Methyl-D-aspartate (NMDA) stimulated 22Na flux from rat hippocampal slices has previously been used to explore the NMDA receptor complex. The pharmacology correlates well with NMDA sensitive [3H]-glutamate receptor binding and with excitotoxicity p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1051f28db5d1797610a85d3f0b4cdedb
https://doi.org/10.1007/978-94-011-2262-7_51
https://doi.org/10.1007/978-94-011-2262-7_51
Publikováno v:
Neurobiology of Amino Acids, Peptides and Trophic Factors ISBN: 9781461289692
The N-methyl-D-aspartate (NMDA) receptor is the best defined subclass of excitatory amino acid receptors with regard to both its electrophysiological properties and the functional consequences of its stimulation and inhibition. However, straightforwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7e902e334c56f6118a883528c5ae4a5
https://doi.org/10.1007/978-1-4613-1721-0_20
https://doi.org/10.1007/978-1-4613-1721-0_20
Autor:
J. Michel, L. M. Pullan, John W. Olney, Madelon T. Price, Joseph B. Monahan, R P Compton, W. F. Hood
Publikováno v:
Journal of neurochemistry. 49(4)
The sulfur-containing amino acids, L- and D-cysteate, L-cysteine, L- and D-cysteine sulfinate, L- and D-cysteine-S-sulfate, L-cystine, L- and D-homocysteate, L- and D-homocysteine sulfinate, L-homocysteine, L-serine-O-sulfate, and taurine were tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497eab72e1d7ea431910687d99543067
https://pubmed.ncbi.nlm.nih.gov/2887637
https://pubmed.ncbi.nlm.nih.gov/2887637
Publikováno v:
Neurobiology of Amino Acids, Peptides and Trophic Factors ISBN: 9781461289692
In pathways where acidic amino acids, such as glutamate, are thought to be the endogenous neurotransmitter, electrophysiological studies have demonstrated that L-2-amino-4-phosphonobutyrate (L-APB) is a potent antagonist of the excitatory responses [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f27b4120e29a44171aa6cb8ea91f2e8
https://doi.org/10.1007/978-1-4613-1721-0_19
https://doi.org/10.1007/978-1-4613-1721-0_19