Zobrazeno 1 - 10
of 10
pro vyhledávání: '"L M, Hiebert"'
Publikováno v:
British journal of pharmacology. 153(6)
An oral, single dose of 7.5 mg kg(-1) of unfractionated heparin (UFH) reduces thrombosis by 50% in a rat model of venous thrombosis. As long-term use is required clinically, our objectives were to study the antithrombotic effects following repeated o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55e1bfe8b47793ca47f75e91dd33431a
https://pubmed.ncbi.nlm.nih.gov/18264127
https://pubmed.ncbi.nlm.nih.gov/18264127
Publikováno v:
Histology and histopathology. 21(9)
We previously reported that high glucose treated cultured endothelial cells (ECs) showed intercellular gaps by transmission electron microscopy (TEM). These gaps were abrogated with insulin and/or heparin treatment. Our aims were to assess the severi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4d6bb14fed0e30e461068e02061e0c4
https://pubmed.ncbi.nlm.nih.gov/16763943
https://pubmed.ncbi.nlm.nih.gov/16763943
Publikováno v:
Canadian journal of physiology and pharmacology. 78(4)
Distribution and antithrombotic activity of orally administered unfractionated porcine heparin were studied. [14C]Heparin was prepared by de-N-acetylation of porcine mucosal heparin followed by re-N-acetylation, using [14C]acetic anhydride. [14C]Hepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66a7886c12d75c31a8de358b3732c8f3
https://pubmed.ncbi.nlm.nih.gov/10772058
https://pubmed.ncbi.nlm.nih.gov/10772058
Publikováno v:
The Quarterly journal of medicine. 86(5)
Plasma levels of the antithrombotic drug heparin, as estimated by coagulation tests, are a poor indicator of antithrombotic effectiveness. The interaction of heparin with endothelium is a poorly studied but important factor in the clinical activity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dac9aab3bceb3e8f32e366719c328c07
https://pubmed.ncbi.nlm.nih.gov/8327652
https://pubmed.ncbi.nlm.nih.gov/8327652
Publikováno v:
The Journal of laboratory and clinical medicine. 117(2)
Heparin, hydrogenated dextran sulfate 8000 (Usherdex 8), and dextran sulfate 8000 were administered to rats, and the total drug was separated and determined in endothelium and plasma. A large amount of each drug was recovered from endothelium 2.4 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1b18d644b11ea64e421d354e05fac87
https://pubmed.ncbi.nlm.nih.gov/1993853
https://pubmed.ncbi.nlm.nih.gov/1993853
Publikováno v:
The Journal of laboratory and clinical medicine. 115(4)
Heparin and dextran sulfates 8000 are separated from citrated plasma by absorption on epichlorohydrin triethanolamine cellulose columns followed by elution with 1.1 and 1.4 mol/L NaCl in 0.05 mol/L glycine-HCl buffer. The eluate is desalted with Seph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e12f08fe90c7edf1b08ea75cb0a33916
https://pubmed.ncbi.nlm.nih.gov/1691256
https://pubmed.ncbi.nlm.nih.gov/1691256
Autor:
L M, Hiebert, N M, McDuffie
Publikováno v:
Artery. 17(2)
Endothelial cells in vivo and in vitro take up heparin following administration. In in vitro systems, cellular and pericellular extracts of monolayers exposed to heparin, demonstrate internalization as well as cell surface attachment. To further inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e88043263466cf9780503194603ed5c
https://pubmed.ncbi.nlm.nih.gov/2155600
https://pubmed.ncbi.nlm.nih.gov/2155600
Autor:
L M, Hiebert, N M, McDuffie
Publikováno v:
Artery. 16(4)
Heparins from bovine or porcine sources were fed in media for 48 hrs to cultured porcine aortic and human umbilical vein endothelial cells. Heparin was found in pericellular and cellular fractions after extraction by chemical methods and 125I radiola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ec9310080e77027ae8296e4065696f8
https://pubmed.ncbi.nlm.nih.gov/2742511
https://pubmed.ncbi.nlm.nih.gov/2742511
Autor:
L M, Hiebert, L B, Jaques
Publikováno v:
Steroids and lipids research. 5(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66374d73aecb96fa4789972aaf4a19f4
https://pubmed.ncbi.nlm.nih.gov/4458124
https://pubmed.ncbi.nlm.nih.gov/4458124
Autor:
L B, Jaques, L M, Hiebert
Publikováno v:
Artery. 16(3)
For over 100 years heparin has attracted interest because of its anticoagulant powers. Commercial heparin has now been shown to be a mixture of over 100 different closely related sulfated polysaccharides of which only 10% activate antithrombin-III. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::562fa2ddf8e08518c6d6c476bb25774d
https://pubmed.ncbi.nlm.nih.gov/2730347
https://pubmed.ncbi.nlm.nih.gov/2730347