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Modification of proinflammatory cytokine production by the antirheumatic agents tenidap and naproxen. A possible correlate with clinical acute phase response

Autor: J D Sipe, L M Bartle, L D Loose

Publikováno v: The Journal of Immunology. 148:480-484

The cytokines IL-6, IL-1, and TNF play a key role in the pathogenesis of rheumatoid arthritis (RA) and initiate hepatic serum amyloid A (SAA) expression after injury. To provide a possible mechanistic explanation for the previous observation that pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8faa1b0fc1cf9eb40e83fdb0c4d6b24d
https://doi.org/10.4049/jimmunol.148.2.480

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Induction of apoptosis by tamoxifen-activation of a p53-estrogen receptor fusion protein expressed in E1A and T24 H-ras transformed p53-/- mouse embryo fibroblasts

Autor: C A, Vater, L M, Bartle, C A, Dionne, T D, Littlewood, V S, Goldmacher

Publikováno v: Oncogene. 13(4)

A fusion gene consisting of wild-type p53 linked to a modified ligand binding domain of the murine estrogen receptor has been constructed and should be a useful tool for studying controlled activation of wild-type p53 function in a variety of experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6e924ff15314aa3be584419baa5f4c2
https://pubmed.ncbi.nlm.nih.gov/8761295

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Synergism of interleukin 1 and interleukin 6 induces serum amyloid A production while depressing fibrinogen: a quantitative analysis

Autor: H, Rokita, L D, Loose, L M, Bartle, J D, Sipe

Publikováno v: The Journal of rheumatology. 21(3)

Production of the serum amyloid A (SAA) proteins in the liver of patients with arthritis can be increased from approximately 1 microgram/ml to1000 micrograms/ml, while fibrinogen (Fg) can be increased from 2 to 9 mg/ml. The increases appear to be reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::626a417b9e075e4b44ef0fbc520ee8e2
https://pubmed.ncbi.nlm.nih.gov/8006883

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