Zobrazeno 1 - 10
of 361
pro vyhledávání: '"L Lever"'
Publikováno v:
Retrovirology, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract Background HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was recently shown to be assoc
Externí odkaz:
https://doaj.org/article/dcfa21ebe39049fb93163139deb473ef
There are three major types of human retroviruses, namely HIV, HTLV, and endogenous human retroviruses. This book presents the latest findings on the replication of these human retroviruses. This book is unique in that there has been no comparable bo
Autor:
Aaron R. D’Souza, Dhivya Jayaraman, Ziqi Long, Jingwei Zeng, Liam J. Prestwood, Charlene Chan, Dennis Kappei, Andrew M. L. Lever, Julia C. Kenyon
Publikováno v:
Viruses, Vol 13, Iss 12, p 2389 (2021)
HIV-1 packages two copies of its gRNA into virions via an interaction with the viral structural protein Gag. Both copies and their native RNA structure are essential for virion infectivity. The precise stepwise nature of the packaging process has not
Externí odkaz:
https://doaj.org/article/f334a79e6870445aa2d9c87e59dd058b
Publikováno v:
Viruses, Vol 13, Iss 11, p 2130 (2021)
Our understanding of RNA structure has lagged behind that of proteins and most other biological polymers, largely because of its ability to adopt multiple, and often very different, functional conformations within a single molecule. Flexibility and m
Externí odkaz:
https://doaj.org/article/719a716a176d44d1b2984ae369a4b33b
Autor:
Nicholas J. Norton, Axel Fun, Mikaila Bandara, Mark R. Wills, Hoi Ping Mok, Andrew M. L. Lever
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-6 (2017)
Abstract A robust measure of the size of the latent HIV reservoir is essential to quantifying the effect of interventions designed to deplete the pool of reactivatable, replication competent proviruses. In addition to the ability to measure a biologi
Externí odkaz:
https://doaj.org/article/fa62bb954a3d4c52aee09194b639d621
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007345 (2019)
HIV-1 replicates via a low-fidelity polymerase with a high mutation rate; strong conservation of individual nucleotides is highly indicative of the presence of critical structural or functional properties. Identifying such conservation can reveal nov
Externí odkaz:
https://doaj.org/article/cb918929c4994360be6f5aab14ef4a11
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Transcriptionally silent HIV proviruses form the major obstacle to eradicating HIV. Many studies of HIV latency have focused on the cellular mechanisms that maintain silencing of proviral DNA. Here we show that viral sequence variation affec
Externí odkaz:
https://doaj.org/article/5ec59ece3af14869b31e20e379fa66bf
Autor:
Bo Meng, Andrew M. L. Lever
Publikováno v:
Viruses, Vol 13, Iss 2, p 324 (2021)
Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading surface proteins, is one of
Externí odkaz:
https://doaj.org/article/c48dd2a460c644dfbcd69edb3ecf31f1
Publikováno v:
Frontiers in Neurology. 14
Recognition of similarities between chronic fatigue syndrome and idiopathic intracranial hypertension (IIH) has raised suggestions that they might be connected, with chronic fatigue syndrome representing a mild version of IIH, sharing many of its sym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a11c532bf796e892fc691ef229eeed
Publikováno v:
Nucleic Acids Research
Clinical usage of lentiviral vectors is now established and increasing but remains constrained by vector titer with RNA packaging being a limiting factor. Lentiviral vector RNA is packaged through specific recognition of the packaging signal on the R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3fe067d2cc2cf29277d01d0edd9a1c
https://doi.org/10.1093/nar/gkab1206
https://doi.org/10.1093/nar/gkab1206