Výsledky vyhledávání - "L L von Moltke"

Short-Term Clarithromycin Administration Impairs Clearance and Enhances Pharmacodynamic Effects of Trazodone but Not of Zolpidem

Autor: Laurie P. Volak, David J. Greenblatt, Michael H. Court, Dora Farkas, L L von Moltke, Jerold S. Harmatz

Publikováno v: Clinical Pharmacology & Therapeutics. 85:644-650

The kinetic and dynamic interactions of 5 mg zolpidem and 50 mg trazodone with 500 mg clarithromycin (4 doses given over 32 h) were investigated in a 5-way double crossover study with 10 healthy volunteers. The five treatment conditions were: placebo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61d0cb323bdd4271ca7cf696395a946
https://doi.org/10.1038/clpt.2008.293

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Role of CYP3A enzymes in the biotransformation of triazolam in rat liver

Autor: Jill S. Warrington, L L von Moltke, David J. Greenblatt

Publikováno v: Xenobiotica. 34:463-471

1. Triazolam (TRZ) has been used extensively in rat to evaluate its benzodiazepine agonist central nervous system effects. However, the pharmacokinetics of TRZ in the male rat are not well understood. 2. To characterize further TRZ biotransformation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2d7ef90aad1369ae521c97b9a2cb0c
https://doi.org/10.1080/00498250410001691299

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Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats

Autor: Michael D. Perloff, David J. Greenblatt, L L von Moltke

Publikováno v: Xenobiotica. 34:133-150

1. The consequences of extended exposure to the human immunodeficiency viral protease inhibitor ritonavir (RIT) on the expression and function of CYP3A isoforms in the liver and in enteric mucosal cells, and on the expression of the efflux transport

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ca36b6ae4f69df297dae1cfaca7c2b
https://doi.org/10.1080/00498250310001630215

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Molecular and Pharmacokinetic Evaluation of Rat Hepatic and Gastrointestinal Cytochrome P450 Induction by Tamoxifen

Autor: L L von Moltke, Jerold S. Harmatz, Monette M. Cotreau, David J. Greenblatt

Publikováno v: Pharmacology. 63:210-219

Tamoxifen (TAM) is a first-line endocrine treatment for all stages of postmenopausal breast cancer. The cytochrome P450 (CYP) enzymes catalyze the majority of TAM’s primary metabolism, producing N-desmethyltamoxifen (DMT) and 4-hydroxytamoxifen (4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1cd0d5c9ed61e5d124c03e95dbf289
https://doi.org/10.1159/000056136

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Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions

Autor: Lisa L. von Moltke, David J. Greenblatt, Brian W. Granda, Jeffrey M. Grassi, Jürgen Schmider, Jerold S. Harmatz, Richard I. Shader, L. L. von Moltke

Publikováno v: Psychopharmacology. 145:113-122

Rationale: Understanding of the mechanisms of biotransformation of antidepressant drugs, and of their capacity to interact with other medications, is of direct relevance to rational clinical psychopharmacology. Objectives: To determine the human cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c542b6e6c82ea9dcb1fc5a48d52158a7
https://doi.org/10.1007/s002130051039

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Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects

Autor: Richard I. Shader, Jerold S. Harmatz, David J. Greenblatt, Jeffrey M. Grassi, L L von Moltke, L. F. Fabre, Steven M. Fogelman, Brian W. Granda, S. J. Kramer

Publikováno v: Psychopharmacology. 140:293-299

Biotransformation of gepirone to its principal metabolite, 1-(2-pyrimidinyl)-piperazine (1-PP), was studied in human liver microsomes and in microsomes from cDNA-transfected human lymphoblastoid cells. Formation of 1-PP from gepirone in liver microso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1839649de8d80773a399d8c85f31e8
https://doi.org/10.1007/s002130050770

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Phenacetin O -deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine

Autor: Steven M. Fogelman, David J. Greenblatt, Leena Kudchadker, Jürgen Schmider, Richard I. Shader, Jerold S. Harmatz, Su Xiang Duan, L L von Moltke

Publikováno v: Psychopharmacology. 128:398-407

Biotransformation of phenacetin via O-deethylation to acetaminophen, an index reaction reflecting activity of Cytochrome P450-1A2, was studied in microsomal preparations from a series of human livers. Acetaminophen formation was consistent with a dou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752f4abae8be99e1ba44df313f7c9ff7
https://doi.org/10.1007/s002130050149

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Inhibition of Terfenadine Metabolism In Vitro by Azole Antifungal Agents and by Selective Serotonin Reuptake Inhibitor Antidepressants

Autor: C. E. Wright, Su Xiang Duan, David J. Greenblatt, Richard I. Shader, Jerold S. Harmatz, L L von Moltke

Publikováno v: Journal of Clinical Psychopharmacology. 16:104-112

Biotransformation of the H-1 antagonist terfenadine to its desalkyl and hydroxy metabolites was studied in vitro using microsomal preparations of human liver. These metabolic reactions are presumed to be mediated by Cytochrome P450-3A isoforms. The a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928adb600da06b9feaec53874d119235
https://doi.org/10.1097/00004714-199604000-00002

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