10-Ethyl-10-deaza-aminopterin: structural design and biochemical, pharmacologic, and antitumor properties

Autor: F M, Sirotnak, F A, Schmid, L L, Samuels, J I, DeGraw

Publikováno v: NCI monographs : a publication of the National Cancer Institute. (5)

The new folate analog 10-ethyl-10-deaza-aminopterin (10EdAM) was equivalent to methotrexate (MTX) as an inhibitor of dihydrofolate reductase, but was more effectively transported and polyglutamylated in most tumor cells. Also, the transport and polyg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8fe4c1caebe7098eafb001567693d299
https://pubmed.ncbi.nlm.nih.gov/2448650

Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites

Autor: Francis M. Sirotnak, Charles W. Young, Pedro M. Vidal, L L Samuels, Michael P. Fanucchi, James J. Kinahan, Fouad M. Farag

Publikováno v: Analytical biochemistry. 150(1)

The antifolate compounds 10-deazaaminopterin (10-dAM) and 10-ethyl-10-deazaaminopterin (10-EdAM) are therapeutically superior to methotrexate in transplanted murine tumor systems and in human tumor xenografts growing in immunodeficient “nude” mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c708b4e25764cca4f30114c93988e96
https://pubmed.ncbi.nlm.nih.gov/2417507

Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro

Autor: L L, Samuels, D M, Moccio, F M, Sirotnak

Publikováno v: Cancer research. 45(4)

Four folate analogues, methotrexate, aminopterin, 10-deazaminopterin, and 10-ethyl-10-deazaaminopterin were assessed for their ability to be metabolized to poly-gamma-glutamyl derivatives in three tumor lines which vary in their sensitivity to these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9cd47c1f9d6a92026e23267e65a0f5db
https://pubmed.ncbi.nlm.nih.gov/3978616

Improved therapeutic index with high-dose methotrexate: comparison of thymidine-purine rescue with citrovorum factor rescue in mice

Autor: L L, Samuels, J A, Straw

Publikováno v: Cancer research. 44(6)

Two biochemically different rescue agents, citrovorum factor (CF) and thymidine-inosine-allopurinol (TIA), were compared in an attempt to identify the mechanism for the increased therapeutic index achieved with high-dose methotrexate (MTX) plus rescu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77234396b7a3e133920ba9a5e609aba7
https://pubmed.ncbi.nlm.nih.gov/6609764

Non-communicable diseases in the Western Area District, Sierra Leone, before and during the Ebola outbreak.

Autor: Samba T; Western Area District Health Management Team, Ministry of Health and Sanitation (MoHS), Freetown, Sierra Leone., Bhat P; Ministry of Health, Government of Karnataka, Bengaluru, India., Owiti P; Academic Model Providing Access to Health Care (AMPATH), Eldoret, Kenya.; International Union Against Tuberculosis and Lung Disease, Paris, France., Samuels L; Western Area District Health Management Team, Ministry of Health and Sanitation (MoHS), Freetown, Sierra Leone., Kanneh PJ; Western Area District Health Management Team, Ministry of Health and Sanitation (MoHS), Freetown, Sierra Leone., Paul R; Western Area District Health Management Team, Ministry of Health and Sanitation (MoHS), Freetown, Sierra Leone., Kargbo B; MoHS, Freetown, Sierra Leone., Harries AD; International Union Against Tuberculosis and Lung Disease, Paris, France.; London School of Hygiene & Tropical Medicine, London, UK.

Publikováno v: Public health action [Public Health Action] 2017 Jun 21; Vol. 7 (Suppl 1), pp. S16-S21.