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Human papillomavirus type 16 E6 and E7 cooperate to increase epidermal growth factor receptor (EGFR) mRNA levels, overcoming mechanisms by which excessive EGFR signaling shortens the life span of normal human keratinocytes

Autor: G S, Akerman, W H, Tolleson, K L, Brown, L L, Zyzak, E, Mourateva, T S, Engin, A, Basaraba, A L, Coker, K E, Creek, L, Pirisi

Publikováno v: Cancer research. 61(9)

Epidermal growth factor receptor (EGFR) levels are dramatically increased in human keratinocytes (HKc) immortalized with full-length human papillomavirus type 16 (HPV16) DNA (HKc/HPV16), but increases in EGFR levels actually precede immortalization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84801d57516d638eea8747563bca771c
https://pubmed.ncbi.nlm.nih.gov/11325860

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Increased levels and constitutive tyrosine phosphorylation of the epidermal growth factor receptor contribute to autonomous growth of human papillomavirus type 16 immortalized human keratinocytes

Autor: L L, Zyzak, L M, MacDonald, A, Batova, R, Forand, K E, Creek, L, Pirisi

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 5(5)

Transfection of individual normal human foreskin keratinocyte (HKc) strains with human papillomavirus type 16 (HPV16) DNA results in the establishment of immortalized cell lines (HKc/HPV16) which, like normal HKc, require epidermal growth factor (EGF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6174b2191915031eb4943e9581e6083a
https://pubmed.ncbi.nlm.nih.gov/8049160

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