Zobrazeno 1 - 7
of 7
pro vyhledávání: '"L L, Moltke"'
Autor:
J M, Fahey, G A, Pritchard, L L, Moltke, J S, Pratt, J M, Grassi, R I, Shader, D J, Greenblatt
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(1)
We previously demonstrated that ketoconazole is a potent inhibitor of triazolam biotransformation in vitro and in vivo. Despite significant elevations in triazolam plasma levels with coadministration of ketoconazole, the pharmacodynamic enhancement w
Publikováno v:
Clinical Pharmacology & Therapeutics. 77:P42-P42
Aims Steroid receptor antagonists, such as tamoxifen (TAM) or mifepristone (MFP), display significant inhibition of the ABC transport protein P-glycoprotein (P-gp) in vitro. To date, interactions between androgen receptor antagonists have yet to be d
Publikováno v:
Clinical Pharmacology & Therapeutics. 77:P41-P41
Background Coadministration of caffeine (CAF) and fluvoxamine (FLU) results in impaired CAF clearance and prolonged elimination half-life. The clinical importance of this interaction, attributable to CYP1A2 inhibition by FLU, remains to be firmly est
Publikováno v:
Clinical Pharmacology & Therapeutics. 75:P38
Attempts at predicting drug-drug interactions (DDI) perpetrated by paroxetine (PX) from in vitro data have utilized reversible enzyme inhibition models and have been unsuccessful to date, grossly underpredicting interaction magnitude. Recent data fro
Publikováno v:
Clinical Pharmacology & Therapeutics. 75:P83
We evaluated the potential for inhibition of CYP3A4 and CYP3A5 using seven mechanism-based inhibitors: troleandomycin (TAO), erythromycin (ERY), 6′, 7′-dihydroxybergamottin (DHB), diltiazem (DIL), verapamil (VER), ethynyl estradiol (EE) and riton
Publikováno v:
Clinical Pharmacology & Therapeutics. 73:P18-P18
Publikováno v:
Clinical Pharmacology & Therapeutics. 65:144-144