Zobrazeno 1 - 10
of 111
pro vyhledávání: '"L L, Kiselev"'
Autor:
T V, Pavlova, V I, Kashuba, O V, Muravenko, S P, Yenamandra, T A, Ivanova, V I, Zabarovskaia, E R, Rakhmanaliev, L A, Petrenko, I V, Pronina, V I, Loginov, O Iu, Iurkevich, L L, Kiselev, A V, Zelenin, E R, Zabarovskiĭ
Publikováno v:
Molekuliarnaia biologiia. 43(2)
New comparative genome hybridization technology on NotI-microarrays is presented (Karolinska Institute International Patent WO02/086163). The method is based on comparative genome hybridization of NotI-probes from tumor and normal genomic DNA with th
Publikováno v:
Molekuliarnaia biologiia. 42(6)
Termination of translation in eukaryotes is governed by two polypeptide chain release factors. The middle (M) domain of the class 1 translation termination factor eRF1 contains the strictly conserved GGQ motif and involved in hydrolysis of the peptid
Autor:
Iu N, Vorob'ev, L L, Kiselev
Publikováno v:
Molekuliarnaia biologiia. 42(2)
A properties of atomic models of structure of eukaryotic triple complex eRF1 . mRNA . tRNAPhe containing human class-1 polypeptide release factor eRF1 at the A-site of human 80S ribosome, mRNA and P-site tRNAPhe, obtained before, are considered. The
Publikováno v:
Molekuliarnaia biologiia. 41(6)
In universal-code eukaryotes, a single class-1 translation termination factor eRF1 decodes all three stop codons, UAA, UAG, and UGA. In some ciliates with variant genetic codes one or two stop codons are used to encode amino acid(s) and are not recog
Autor:
Iu N, Vorob'ev, L L, Kiselev
Publikováno v:
Molekuliarnaia biologiia. 41(1)
Models of atomic structure of eukaryotic translation termination complex containing mRNA, P-site tRNAPhe, human class-1 polypeptide release factor eRF1 and 80S ribosome were constructed. The method of computational modeling was applied. The modeling
Autor:
T D, Mashkova, N Iu, Oparina, O L, Zinov'eva, E S, Kropotova, V I, Dubovaia, A B, Poltaraus, M V, Fridman, E P, Kopantsev, T V, Vinogradova, M V, Zinov'eva, K K, Laktionov, O T, Kasymova, I B, Zborovskaia, E D, Sverdlov, L L, Kiselev
Publikováno v:
Molekuliarnaia biologiia. 40(6)
Lung cancer is one of the most frequent neoplasia in the Russia, the United States and Europe. This cancer is associated with functional activity changes of many genes. In the present study TIMP3, DAPK1 and AKR1B10 genes transcription analysis of squ
Publikováno v:
Molekuliarnaia biologiia. 40(2)
Translation termination in eukaryotes is governed by two proteins, belonging to the class-1 (eRF1) and class-2 (eRF3) polypeptide release factors. eRF3 catalyzes hydrolysis of GTP to GDP and inorganic phosphate in the ribosome in the absence of mRNA,
Publikováno v:
Molekuliarnaia biologiia. 40(1)
Thermal denaturation of eukaryotic class-1 translation termination factor eRF1 and its mutants was examined using differential scanning microcalorimetry (DSK). Changes of free energy caused by mutants in the N domain of human eRF1 were calculated. Me
Publikováno v:
Molekuliarnaia biologiia. 38(2)
The integral structural parameters and the shape of the molecule of human translation termination factor eRF1 were determined from the small-angle X-ray scattering in solution. The molecular shapes were found by bead modeling with nonlinear minimizat
Publikováno v:
Molekuliarnaia biologiia. 38(2)
The review considers the results obtained by several groups in the fields of identification of polymorphic loci in the human genome, localization and analysis of genes associated with epithelial tumors of various origins, and generation of molecular