Výsledky vyhledávání - "L L, Houston"

Avidity-Mediated Enhancement of In vivo Tumor Targeting by Single-Chain Fv Dimers

Autor: John E. McCartney, James S. Huston, Louis M. Weiner, Mei-Sheng Tai, L. L. Houston, Gregory P. Adams, James D. Marks, Walter F. Stafford

Publikováno v: Clinical Cancer Research. 12:1599-1605

Radiolabeled single-chain Fv (sFv) molecules display highly specific tumor retention in the severe combined immunodeficient (SCID) mouse model; however, the absolute quantity of sFv retained in the tumors is diminished by the rapid renal elimination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e092d0e4bdc85653ba55ddb1d06ff8b
https://doi.org/10.1158/1078-0432.ccr-05-2217

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Targeting tumor cellsvia EGF receptors: Selective toxicity of an HBEGF-toxin fusion protein

Autor: John R. McDonald, Andrew Baird, Janet E. Price, Barbara A. Sosnowski, Lois A. Chandler, L. L. Houston, Glenn F. Pierce, Sharon Lea Aukerman

Publikováno v: International Journal of Cancer. 78:106-111

Over-expression of the epidermal growth factor receptor (EGFR) is a hallmark of numerous solid tumors, thus providing a means of selectively targeting therapeutic agents. Heparin-binding epidermal growth factor (HBEGF) binds to EGFRs with high affini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e633ae412d950fb272db2299762a4e46
https://doi.org/10.1002/(sici)1097-0215(19980925)78:1<106::aid-ijc17>3.0.co

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Synthesis and Characterization of a Homogeneous Chemical Conjugate Between Basic Fibroblast Growth Factor and Saporin

Autor: Chun Shen, Zahra Parandoosh, Kimberly D. Victor, Marie Ryder, Stuart Bussell, L. L. Houston, Barbara A. Sosnowski, Ying Buechler

Publikováno v: European Journal of Biochemistry. 234:706-713

Basic fibroblast growth factor (FGF-2) and saporin were chemically conjugated using the crosslinker, N -succinimidyl-3(2-pyridyldithio)-propionate. When purified, the conjugate was found to be heterogeneous as analyzed by SDS/PAGE, size-exclusion HPL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1c3bddf445d0b9960f34d01a63eded
https://doi.org/10.1111/j.1432-1033.1995.706_a.x

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Optimization of in vivo tumor targeting in SCID mice with divalent forms of 741F8 anti-c-erbB-2 single-chain Fv: effects of dose escalation and repeated i.v. administration

Autor: Jamie Eisenberg, John E. McCartney, Michael A. Bookman, Gregory P. Adams, E J Wolf, Walter F. Stafford, Mei-Sheng Tai, L. L. Houston, Louis M. Weiner, James S. Huston

Publikováno v: Cancer Immunology, Immunotherapy. 40:299-306

Single-chain Fv molecules in monovalent (sFv) and divalent [(sFv')2] forms exhibit highly specific tumor targeting in mice as a result of their small size and rapid systemic clearance. As a consequence, there is a rapid reversal of the sFv blood/tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902c4531e34f46172e3f31b3a579bc7e
https://doi.org/10.1007/bf01519629

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Radiometal labeling of recombinant proteins by a genetically engineered minimal chelation site: technetium-99m coordination by single-chain Fv antibody fusion proteins through a C-terminal cysteinyl peptide

Autor: F Jamar, M S Tai, Louis M. Weiner, L L Houston, A. M. Peters, Hermann Oppermann, G P Adams, B T Heelan, Andrew J.T. George, John E. McCartney

Publikováno v: Proceedings of the National Academy of Sciences. 92:8358-8362

We describe a method to facilitate radioimaging with technetium-99m (99mTc) by genetic incorporation of a 99mTc chelation site in recombinant single-chain Fv (sFv) antibody proteins. This method relies on fusion of the sFv C terminus with a Gly4Cys p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931e2f825c690cb439eb086f4b1f9b90
https://doi.org/10.1073/pnas.92.18.8358

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Preclinical Studies and Optimization of Specific Tumor Delivery for 741F8 sFv, an Anti-c-erbB-2 Single-Chain Species

Autor: John E. McCartney, Axel A. Laminet, James S. Huston, Louis M. Werner, Mei-Sheng Tai, Gregory P. Adams, Sen Liu, Josephine Schultz, Jamie Eisenberg, E J Wolf, Gerald Apell, L. L. Houston, Hermann Oppermann, Walter F. Stafford, Bruce J. Giantonio, Michael A. Bookman

Publikováno v: International Journal of Pharmacognosy. 33:75-91

Single-chain Fv fragments (sFv) that bind tumor-associated antigens exhibit highly specific tumor targeting characteristics, based on studies of intravenous sFv administration to immunodeficient mice bearing human tumor xenografts. These features sug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f14c21278870505fbb9ed0cf1aa4fcca
https://doi.org/10.3109/13880209509067090

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Engineering disulfide-linked single-chain Fv dimers [(sFv')2] with improved solution and targeting properties: anti-digoxin 26–10 (sFv')2 and anti-c-erbB-2 741F8 (sFv')2 made by protein folding and bonded through C-terminal cysteinyl peptides

Autor: Sen Liu, Gregory P. Adams, Mei-Sheng Tai, Hermann Oppermann, Donald Jin, John E. McCartney, James S. Huston, Robert M. Hudziak, Axel A. Laminet, Irwin Fand, Michael A. Bookman, Louis M. Weiner, Walter F. Stafford, L. L. Houston

Publikováno v: "Protein Engineering, Design and Selection". 8:301-314

Single-chain Fv fusions with C-terminal cysteinyl peptides (sFv') have been engineered using model sFv proteins based upon the 26-10 anti-digoxin IgG and 741F8 anti-c-erbB-2 IgG monoclonal antibodies. As part of the 741F8 sFv construction process, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbcb2dd232369614f19186a6586b3647
https://doi.org/10.1093/protein/8.3.301

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Mammalian Cell Expression of Single–Chain Fv (sFv) Antibody Proteins and Their C–terminal Fusions with Interleukin–2 and Other Effector Domains

Autor: James S. Huston, Haimanti Dorai, Mei-Sheng Tai, Hermann Oppermann, Axel A. Laminet, John E. McCartney, L. L. Houston, Robert M. Hudziak

Publikováno v: Nature Biotechnology. 12:890-897

The production of several single-chain Fv (sFv) antibody proteins was examined by three modes of mammalian cell expression. Our primary model was the 741F8 anti-c-erbB-2 sFv, assembled as either the VH-VL or VL-VH, and expressed alone, with C-termina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a79aaa738d4826579e18bc3608925b
https://doi.org/10.1038/nbt0994-890

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Suppression of Human Corneal Epithelial Proliferation with Breast Carcinoma Immunotoxin

Autor: Diane L. Hatchell, L M Cobo, M Wilkerson, L. L. Houston, Gary N. Foulks, Fulcher S

Publikováno v: Cornea. 12:391-396

We examined the effects of the immunotoxin 260F9 Mab-recombinant ricin A (developed against human breast carcinoma) on proliferating and confluent human corneal epithelium (HCE) cells in vitro. HCE cells derived from explants of discarded human donor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb71b2c22a8c14109cf48fd48fc123e
https://doi.org/10.1097/00003226-199309000-00004

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Elimination of clonogenic breast cancer cells from human bone marrow. A comparison of immunotoxin treatment with chemoimmunoseparation using 4-hydroperoxycyclophosphamide, monoclonal antibodies, and magnetic microspheres

Autor: L. L. Houston, Robert C. Bast, William P. Peters, Kathy O'Briant, Elizabeth J. Shpall

Publikováno v: Cancer. 68:1272-1278

Autologous bone marrow transplantation (ABMT) may aid in the management of breast cancer, but is currently limited to patients without bone marrow metastases. In earlier studies, 5 logs of malignant clonogenic breast cancer cells could be eliminated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7de87798d8417c8a82e9df4513101cd7
https://doi.org/10.1002/1097-0142(19910915)68:6<1272::aid-cncr2820680616>3.0.co

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