Zobrazeno 1 - 10
of 10
pro vyhledávání: '"L L, Habeck"'
Autor:
L L Habeck, Stanton B. Gelvin
Publikováno v:
Journal of Bacteriology. 172:1600-1608
Mutation of the genes virA, virB, virC, and virG of the Agrobacterium tumefaciens octopine-type Ti plasmid pTiR10 was found to cause a 100- to 10,000-fold decrease in the frequency of conjugal transfer of this plasmid between Agrobacterium cells. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8db7c2bb1b21904abe33f2cef572dcf
https://doi.org/10.1128/jb.172.3.1600-1608.1990
https://doi.org/10.1128/jb.172.3.1600-1608.1990
Autor:
L L, Habeck, R M, Belagaje, G W, Becker, J E, Hale, L M, Churgay, M, Ulmer, X Y, Yang, K A, Shackelford, J M, Richardson, M G, Johnson, L G, Mendelsohn
Publikováno v:
The Prostate. 46(4)
Prostate-specific antigen (PSA), a member of the kallikrein family of serine proteases, is a chymotrypsin-like glycoprotein produced by the prostate epithelium. Elevated serum PSA (4 ng/ml) is a tumor marker for prostatic cancer and benign prostatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ef7474d24f13324aa775f0f3e5c6d38
https://pubmed.ncbi.nlm.nih.gov/11241552
https://pubmed.ncbi.nlm.nih.gov/11241552
Publikováno v:
Seminars in oncology. 26(2 Suppl 6)
The pyrrolopyrimidine-based antifolate, N-¿4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]benzoyl¿glutamic acid, LY231514 (MTA) has demonstrated antitumor activity in a broad array of human tumors, including breast cancer, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48a1da6119e27c5f75d230d6b5e01b0d
https://pubmed.ncbi.nlm.nih.gov/10598554
https://pubmed.ncbi.nlm.nih.gov/10598554
Autor:
J L, Tonkinson, L L, Habeck, J E, Toth, L G, Mendelsohn, J, Bewley, K A, Shackelford, S B, Gates, J, Ray, V J, Chen
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(1)
5,6,7,8-Tetrahydro-N5,N10-carbonylfolic acid (LY354899) has been demonstrated to inhibit the dehydrogenase activity of C1-tetrahydrofolate synthase. This compound was only moderately antiproliferative toward CCRF-CEM lymphocytic leukemia cells in cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86d02a5af10a5e8d8e20bbf13e312e17
https://pubmed.ncbi.nlm.nih.gov/9765352
https://pubmed.ncbi.nlm.nih.gov/9765352
Autor:
C, Shih, V J, Chen, L S, Gossett, S B, Gates, W C, MacKellar, L L, Habeck, K A, Shackelford, L G, Mendelsohn, D J, Soose, V F, Patel, S L, Andis, J R, Bewley, E A, Rayl, B A, Moroson, G P, Beardsley, W, Kohler, M, Ratnam, R M, Schultz
Publikováno v:
Cancer research. 57(6)
N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo[2,3-d]pyrimidine-based antifolate currently undergoing extensive Phase II clinical trials. Previous studies have establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0225038e454981676e617741fec3d59
https://pubmed.ncbi.nlm.nih.gov/9067281
https://pubmed.ncbi.nlm.nih.gov/9067281
Autor:
S B, Gates, L G, Mendelsohn, K A, Shackelford, L L, Habeck, J D, Kursar, L S, Gossett, J F, Worzalla, C, Shih, G B, Grindey
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(7)
Membrane-associated folate receptors (FRs) have been detected in many mammalian species, and multiple isoforms have been identified. The pharmacological properties of FRs from murine kidney, liver, and six murine tumors were characterized. Murine kid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e351458dc56644c909c826976e41a81
https://pubmed.ncbi.nlm.nih.gov/9816279
https://pubmed.ncbi.nlm.nih.gov/9816279
Autor:
L L, Habeck, L G, Mendelsohn, C, Shih, E C, Taylor, P D, Colman, L S, Gossett, T A, Leitner, R M, Schultz, S L, Andis, R G, Moran
Publikováno v:
Molecular pharmacology. 48(2)
The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate synthetase (FPGS) plays a central role in the activity of this compound as an antineoplastic agent. The availability of a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ed8e094b41fc87a70247abc4f91956c
https://pubmed.ncbi.nlm.nih.gov/7651366
https://pubmed.ncbi.nlm.nih.gov/7651366
Autor:
L L, Habeck, T A, Leitner, K A, Shackelford, L S, Gossett, R M, Schultz, S L, Andis, C, Shih, G B, Grindey, L G, Mendelsohn
Publikováno v:
Cancer research. 54(4)
Tight-binding inhibition of recombinant human monofunctional glycinamide ribonucleotide formyltransferase by Lometrexol (6R-5,10-dideazatetrahydrofolate) requires polyglutamation. LY254155 and LY222306 differ from 5,10-dideazatetrahydrofolate in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e76d346b8589dba52d6d25ffa45345e9
https://pubmed.ncbi.nlm.nih.gov/8313357
https://pubmed.ncbi.nlm.nih.gov/8313357
Publikováno v:
The Plant cell. 4(1)
Previous work has shown that the octopine synthase (ocs) gene encoded by the Agrobacterium tumefaciens Ti-plasmid contains an upstream activating sequence necessary for its expression in plant cells. This sequence is composed of an essential 16-bp pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f91d3cde25baaaaf67b67ca0943927
https://pubmed.ncbi.nlm.nih.gov/1525561
https://pubmed.ncbi.nlm.nih.gov/1525561
Publikováno v:
Molecular Plant-Microbe Interactions. 6:144
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::310107de6df5552b4fb331faf9965c90
https://doi.org/10.1094/mpmi-6-144
https://doi.org/10.1094/mpmi-6-144