Zobrazeno 1 - 10
of 11
pro vyhledávání: '"L L, Brockunier"'
Publikováno v:
Behavioural Pharmacology. 10:543-547
The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate-decreasing effects of mirfentanil, morphine, naltrexon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7883d669b1fe8665fe4b8e5f0bfea369
https://doi.org/10.1097/00008877-199909000-00012
https://doi.org/10.1097/00008877-199909000-00012
Publikováno v:
Psychopharmacology. 137:67-73
Mirfentanil is a fentanyl derivative with non-opioid actions, including non-opioid antinociceptive effects in rhesus monkeys. The current study examined the rate-altering effects of mirfentanil and several other compounds in pigeons to assess: 1) the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a2164be00a50efdea8acd1595c4695
https://doi.org/10.1007/s002130050594
https://doi.org/10.1007/s002130050594
Autor:
C P, France, S C, Ahn, L L, Brockunier, J R, Bagley, M R, Brandt, P J, Winsauer, J M, Moerschbaecher
Publikováno v:
Pharmacology Biochemistry and Behavior. 59:295-303
Several fentanyl derivatives have been reported to have novel pharmacologies that might be exploited for developing alternate approaches to the treatment of pain. The purpose of the current series of studies was to evaluate OHM3507, a novel fentanyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58e6f630ee1456e1b2bd99d588a3e7a
https://doi.org/10.1016/s0091-3057(97)00417-6
https://doi.org/10.1016/s0091-3057(97)00417-6
Autor:
D. B. Bylund, L. L. Brockunier, D. V. Pratt, L. V. Kudzma, S. Harris, R. A. Del Vecchio, C. R. Pandit, Thomas P. Jerussi, J. R. Bagley, A. Galdes
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f94669308d181b944912560c075f880e
https://doi.org/10.1002/chin.199524117
https://doi.org/10.1002/chin.199524117
Publikováno v:
Pharmacology, biochemistry, and behavior. 64(2)
Three monkeys discriminated 1.78 mg/kg of mirfentanil while responding under a fixed-ratio 5 schedule of stimulus-shock termination. Two mirfentanil derivatives, OHM3295 and OHM10579, substituted for mirfentanil in all subjects. However, other drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4144799699a6489727fbebfa3a9ad7a
https://pubmed.ncbi.nlm.nih.gov/10515315
https://pubmed.ncbi.nlm.nih.gov/10515315
Publikováno v:
Pharmacology, biochemistry, and behavior. 60(3)
The discriminative-stimulus, respiratory, and antinociceptive effects of OHM10579, an isotopic isomer of mirfentanil, were characterized in rhesus monkeys. In monkeys discriminating nalbuphine, 0.32 mg/kg of OHM10579 partially substituted for nalbuph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3695cea681b0f8b93e9b4063f8828c
https://pubmed.ncbi.nlm.nih.gov/9678650
https://pubmed.ncbi.nlm.nih.gov/9678650
Publikováno v:
Advances in experimental medicine and biology. 402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27faaae438a97582c13505896adbf845
https://pubmed.ncbi.nlm.nih.gov/8787637
https://pubmed.ncbi.nlm.nih.gov/8787637
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(3)
Recently, the fentanyl-related compound OHM3295 has been shown to induce a naltrexone-sensitive, dose-related analgesia in CD1 mice. However, unlike morphine or fentanyl, which are potent immunosuppressive drugs, OHM3295 has been found to augment spl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::baa090fcc1a2b40ee28a8140380b5aaa
https://pubmed.ncbi.nlm.nih.gov/7562500
https://pubmed.ncbi.nlm.nih.gov/7562500
Autor:
C P, France, L R, Gerak, D, Flynn, G D, Winger, F, Medzihradsky, J R, Bagley, L L, Brockunier, J H, Woods
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(1)
These studies examined the opioid receptor binding affinities and behavioral effects of several fentanyl derivatives in rhesus monkeys. OHM3295, OHM3296, OHM3326 and OHM3463 displayed high affinity for mu (IC50 = 7-66 nM) as compared to kappa (IC50 =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4da8aafcb08137c71867e56a4798a88
https://pubmed.ncbi.nlm.nih.gov/7616395
https://pubmed.ncbi.nlm.nih.gov/7616395
Publikováno v:
Behavioural Pharmacology. 9:S109
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43227a0c1599fd025b8663e04f7c5e20
https://doi.org/10.1097/00008877-199808001-00253
https://doi.org/10.1097/00008877-199808001-00253