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Akademický článek

Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain

Autor: Wenbi Wu, Pankaj Kumar, Chad A. Brautigam, Shih-Chia Tso, Hamid R. Baniasadi, Daniel L. Kober, Marie-Alda Gilles-Gonzalez

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract The heme-based direct oxygen sensor DosP degrades c-di-GMP, a second messenger nearly unique to bacteria. In stationary phase Escherichia coli, DosP is the most abundant c-di-GMP phosphodiesterase. Ligation of O2 to a heme-binding PAS domain

Externí odkaz: https://doaj.org/article/5f8938b3620241c8a2f60ccd8f87985e

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Akademický článek

SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain

Autor: Sebastian Hendrix, Vincent Dartigue, Hailee Hall, Shrankhla Bawaria, Jenina Kingma, Bilkish Bajaj, Noam Zelcer, Daniel L. Kober

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Site-one protease (S1P) conducts the first of two cleavage events in the Golgi to activate Sterol regulatory element binding proteins (SREBPs) and upregulate lipogenic transcription. S1P is also required for a wide array of additional signal

Externí odkaz: https://doaj.org/article/37ed8873d23d4923aecc3d62781541c8

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Akademický článek

Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis

Autor: Shimeng Xu, Linda Donnelly, Daniel L. Kober, Myra Mak, Arun Radhakrishnan

Publikováno v: Journal of Lipid Research, Vol 65, Iss 11, Pp 100650- (2024)

Membrane-associated ring-CH-type finger 6 (MARCH6), also designated as TEB4 or RNF176, is an E3 ligase that is embedded in membranes of the endoplasmic reticulum where it ubiquitinates many substrate proteins to consign them to proteasome-mediated de

Externí odkaz: https://doaj.org/article/34d9ec7f903c4613bc3e63e11f0b7af4

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Akademický článek

Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo

Autor: Daniel L. Kober, Marley C. Caballero Van Dyke, Jennifer L. Eitson, Ian N. Boys, Matthew B. McDougal, Daniel M. Rosenbaum, John W. Schoggins

Publikováno v: mBio, Vol 15, Iss 6 (2024)

ABSTRACT The rapid evolution of SARS-CoV-2 variants highlights the need for new therapies to prevent disease spread. SARS-CoV-2, like SARS-CoV-1, uses the human cell surface protein angiotensin-converting enzyme 2 (ACE2) as its native receptor. Here,

Externí odkaz: https://doaj.org/article/bb44b7e8a55249a1bd0f9458bb7da61a

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Familial predisposition to cardiovascular disease and death in patients with an out-of-hospital cardiac arrest

Autor: M Gylling, J Kroll, P E Warming, C M Hansen, F Folke, S M Hansen, L Kober, C Torp-Pedersen, R Garcia, J Tfelt-Hansen, P Weeke

Publikováno v: Europace. 25

Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Rigshospitalet Introduction Familial predisposition to cardiovascular disease (CVD) and death among patients with out-of-hospital cardiac arrest (OHCA), is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a37532941abd63c76f85c87f089a75d
https://doi.org/10.1093/europace/euad122.286

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Morphology-Voltage-P-wave-duration (MVP) score to select patients for continuous atrial fibrillation screening to prevent stroke

Autor: L Y Xing, S Z Diederichsen, S Hojberg, D W Krieger, C Graff, M S Olesen, J B Nielsen, A Brandes, L Kober, K J Haugan, J H Svendsen

Publikováno v: Europace. 25

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): The LOOP Study was funded by Innovation Fund Denmark [grant number 12-1352259], The Research Foundation for the Capital Region of Denmark, The Danish Heart Foundati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14e3e23cdf9787ae106dd9913748a5a0
https://doi.org/10.1093/europace/euad122.199

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Centralisation of post-resuscitation care after out-of-hospital cardiac arrest at heart centres - a nationwide follow-up study

Autor: S Rasalingam Mork, E Gregers, K Kragholm, J Kjaergaard, F Folke, C Torp-Pedersen, L Kober, A M Boas Soja, C Juhl Terkelsen, F Michalik, J Eifer Moller, F Lund Henriksen, K Bundgaard Ringgren, C Hassager, H Soholm

Publikováno v: European Heart Journal: Acute Cardiovascular Care. 12

Funding Acknowledgements Type of funding sources: None. Background Recent guidelines recommend centralisation of post-resuscitation care in out-of-hospital cardiac arrest (OHCA) patients in dedicated Cardiac Arrest Centres (CACs) aiming to improve ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::816a1c9734312f8edf14adccaad188f1
https://doi.org/10.1093/ehjacc/zuad036.064

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Akademický článek

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Akademický článek

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