Zobrazeno 1 - 10
of 36
pro vyhledávání: '"L Keith, Henry"'
Autor:
Danielle O. Sambo, Min Lin, Anthony Owens, Joseph J. Lebowitz, Ben Richardson, Darin A. Jagnarine, Madhur Shetty, Meghan Rodriquez, Taiwo Alonge, Mishaal Ali, Jonathan Katz, Long Yan, Marcelo Febo, L. Keith Henry, Adriaan W. Bruijnzeel, Lynette Daws, Habibeh Khoshbouei
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
The dopamine transporter (DAT), a regulator of dopamine homeostasis in the brain, and sigma-1 receptor (σ1R), an endoplasmic reticulum membrane protein, are both implicated in drug addiction. In this work, the authors investigate how σ1R modulates
Externí odkaz:
https://doaj.org/article/0d6245895b2e42a080e1391355fcd9ae
Autor:
Ben D. Richardson, Kaustuv Saha, Danielle Krout, Elizabeth Cabrera, Bruce Felts, L. Keith Henry, Jarod Swant, Mu-Fa Zou, Amy Hauck Newman, Habibeh Khoshbouei
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The dopaminergic system has important roles in a number of cognitive process. Here, the authors use detailed analysis of dopamine transporter trafficking to show its levels at the cell surface are sensitive to changes in membrane potential.
Externí odkaz:
https://doaj.org/article/6f106f3acb6d481bbed0b3a48bcfa7a6
Autor:
Akula Bala Pramod, John R. Lever, Danielle Krout, L. Keith Henry, Michael J. Tomlinson, Roxanne A. Vaughan, Amy Hauck Newman
Publikováno v:
Neurochemistry International. 123:34-45
The dopamine transporter (DAT) is a neuronal membrane protein that is responsible for reuptake of dopamine (DA) from the synapse and functions as a major determinant in control of DA neurotransmission. Cocaine and many psychostimulant drugs bind to D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fab52217f366071b74cf849452af5be5
https://doi.org/10.1016/j.neuint.2018.08.008
https://doi.org/10.1016/j.neuint.2018.08.008
Autor:
Randy D. Blakely, Paul J. Gresch, Danielle Krout, L. Keith Henry, Rania M. Katamish, Meagan A. Quinlan, Matthew J. Robson, Catherine Nettesheim, Deborah C Mash
Publikováno v:
ACS Chem Neurosci
The antidepressant-sensitive serotonin (5-HT) transporter (SERT) dictates rapid, high-affinity clearance of the neurotransmitter in both the brain and periphery. In a study of families with multiple individuals diagnosed with autism spectrum disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829173a2643ff7e2ccb72ffc1bafc7e0
https://doi.org/10.1021/acschemneuro.8b00689
https://doi.org/10.1021/acschemneuro.8b00689
Autor:
Constantin J. Pournaras, Emmanuelle Ranza, Jawad Ahmed, Aziz Qurban, Muhammad Ansar, Maleeha Azam, Omer Farooq, Mateusz Kecik, Sohail A. Paracha, Federico Santoni, Carlo Rivolta, Madhur Shetty, Raheel Qamar, Yacine Aggoun, Periklis Makrythanasis, Ilse Kern, Ariane Malclès, Waqar Muzaffar, Stylianos E. Antonarakis, Justyna Iwaszkiewicz, L. Keith Henry, Liaqat Ali, Muhammad T. Sarwar
Publikováno v:
Human Molecular Genetics, Vol. 29, No 4 (2020) pp. 618-623
In a consanguineous Pakistani family with two affected individuals, a homozygous variant Gly399Val in the eighth transmembrane domain of the taurine transporter SLC6A6 was identified resulting in a hypomorph transporting capacity of ~15% compared wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93236516b8b85a990bb421150e887bff
https://archive-ouverte.unige.ch/unige:142242
https://archive-ouverte.unige.ch/unige:142242
Autor:
Danielle Krout, Akula Bala Pramod, Michael J. Tomlinson, James D. Foster, Rejwi Acharya Dahal, Mu Fa Zou, John R. Lever, L. Keith Henry, Comfort Boatang, Roxanne A. Vaughan, Amy Hauck Newman, Babita Sharma
Publikováno v:
Biochem Pharmacol
Dopamine transporter (DAT) blockers like cocaine and many other abused and therapeutic drugs bind and stabilize an inactive form of the transporter inhibiting reuptake of extracellular dopamine (DA). The resulting increases in DA lead to the ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4cf1746a57566cffa45a5dd17210d46
https://doi.org/10.1016/j.bcp.2017.07.015
https://doi.org/10.1016/j.bcp.2017.07.015
Autor:
Allison M.J. Anacker, Noelle C. Anastasio, Nina M Vaswani, Jing Wang, Linda D. Simmler, Michael H Levin, Jeremy Veenstra-VanderWeele, Kathryn A. Cunningham, Adele Stewart, Bing Zhang, Sonja J. Stutz, L. Keith Henry, Randy D. Blakely, Alex Nackenoff, Paul J. Gresch
Publikováno v:
British Journal of Pharmacology. 174:2716-2738
Background and Purpose The psychostimulant cocaine induces complex molecular, cellular and behavioral responses as a consequence of inhibiting presynaptic dopamine, noradrenaline and serotonin (5-HT) transporters. To elucidate 5-HT transporter (SERT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1309f47635f8ede35670a6507877364b
https://doi.org/10.1111/bph.13899
https://doi.org/10.1111/bph.13899
Autor:
L. Keith Henry, Mikhail Y. Golovko, Meghan Rodriquez, Stephen A. Brose, Danielle Krout, Brent J. Thompson
Publikováno v:
ACS Chemical Neuroscience
Previous studies of transgenic mice carrying a single isoleucine to methionine substitution (I172M) in the serotonin transporter (SERT) demonstrated a loss of sensitivity to multiple antidepressants (ADs) at SERT. However, the ability of AD metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b9ea4f88d4a2b2cf711d4cddb23926
https://doi.org/10.1021/acschemneuro.6b00343
https://doi.org/10.1021/acschemneuro.6b00343
Autor:
Natalie R, Sealover, Bruce, Felts, Charles P, Kuntz, Rachel E, Jarrard, Gregory H, Hockerman, Patrick W, Lamb, Eric L, Barker, L Keith, Henry
Publikováno v:
Biochemical Pharmacology. 120:46-55
The substituted amphetamine, 3,4-methylenedioxy-methamphetamine (MDMA, ecstasy), is a widely used drug of abuse that induces non-exocytotic release of serotonin, dopamine, and norepinephrine through their cognate transporters as well as blocking the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f05a06d1aed6c5050d8d4bd361066a
https://doi.org/10.1016/j.bcp.2016.09.006
https://doi.org/10.1016/j.bcp.2016.09.006
Autor:
Meghan Rodriquez, Bony De Kumar, Danielle Perley, Elizabeth Black, L. Keith Henry, Madhur Shetty, Matthew Kretschmar
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d019acc368ff80b62689f50e21065a
https://doi.org/10.1096/fasebj.2020.34.s1.06398
https://doi.org/10.1096/fasebj.2020.34.s1.06398