Zobrazeno 1 - 10
of 27
pro vyhledávání: '"L K Myers"'
Publikováno v:
The Journal of Immunology. 158:6013-6018
Tolerization of B10.RIII mice (H-2r) with i.v.-injected type II collagen (CII) renders the animals resistant to induction of collagen-induced arthritis (CIA). The B10.RIII mouse is of particular interest, in that the T cell determinants that induce t
Publikováno v:
The Journal of Immunology. 157:5178-5184
Collagen-induced arthritis (CIA) is an experimental autoimmune disease elicited in genetically susceptible strains of mice by immunization with heterologous type II collagen. This experimental disease is mediated by the immune response of both T cell
Publikováno v:
The Journal of Immunology. 152:3088-3097
Collagen-induced arthritis (CIA) is an experimental autoimmune disease elicited in genetically susceptible strains of mice by immunization with heterologous type II collagen. This experimental disease is mediated by the immune response of both T and
Publikováno v:
Diabetes. 42:1415-1424
Publikováno v:
The Journal of Immunology. 151:500-505
Chick type II collagen (CII), a protein commonly found in joint cartilage, induces an autoimmune arthritis when administered to susceptible strains of mice. A cyanogen bromide fragment of CII, CB11, contains the requisite epitopes critical for induci
Publikováno v:
The Journal of Immunology. 150:4652-4658
The immunization of genetically susceptible strains of mice with type II collagen (CII) elicits a collagen-induced arthritis that resembles rheumatoid arthritis. Our laboratory previously identified a region of CII, CII-245-270, that contains a T cel
Publikováno v:
The Journal of Immunology. 149:1439-1443
A synthetic peptide representing sequences of type II collagen, (CII 245-270), has previously been used to induce tolerance and suppress arthritis in DBA/1 mice. To determine important residues, a series of peptides, each containing one or two site-d
Autor:
L K, Myers, G C, Higgins, T H, Finkel, A M, Reed, J W, Thompson, R C, Walton, J, Hendrickson, N C, Kerr, R K, Pandya-Lipman, B V, Shlopov, P, Stastny, A E, Postlethwaite, A H, Kang
Publikováno v:
Arthritis and rheumatism. 44(8)
Joint inflammation in juvenile rheumatoid arthritis (JRA) is sometimes associated with an autoimmune response to type II collagen (CII), a cartilage-specific protein. To test the hypothesis that down-regulation of autoimmunity to CII can be accomplis
Autor:
L K, Myers, A H, Kang, A E, Postlethwaite, E F, Rosloniec, S G, Morham, B V, Shlopov, S, Goorha, L R, Ballou
Publikováno v:
Arthritis and rheumatism. 43(12)
To determine the effects of cyclooxygenase 1 (COX-1) and COX-2 gene deletion on collagen-induced arthritis (CIA).Mice that were susceptible to CIA but lacked either the COX-1 or the COX-2 gene were immunized with type II collagen (CII), and the incid
Autor:
K M, McKown, L D, Carbone, S B, Kaplan, J A, Aelion, K M, Lohr, M A, Cremer, J, Bustillo, M, Gonzalez, G, Kaeley, E L, Steere, G W, Somes, L K, Myers, J M, Seyer, A H, Kang, A E, Postlethwaite
Publikováno v:
Arthritis and rheumatism. 42(6)
To investigate the efficacy of oral type II collagen (CII) in the treatment of rheumatoid arthritis (RA), when added to existing therapy.Patients with active RA (n = 190) were randomized into a 6-month, double-blind, placebo-controlled trial. Patient