Zobrazeno 1 - 10
of 62
pro vyhledávání: '"L K Keefer"'
Publikováno v:
Xenobiotica. 32:339-347
1. The single-dose plasma pharmacokinetics of O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) following intravenous (i.v.) and intraperitoneal (i.p.) bolus administration to the male C57BL/6 mouse was studied in an effort to chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816ffe94c3f794c05924941236fa1aed
https://doi.org/10.1080/00498250110102665
https://doi.org/10.1080/00498250110102665
Publikováno v:
Clinical & Experimental Metastasis. 14:335-343
Adhesion of circulating tumor cells to microvascular endothelium plays an important role in tumor metastasis to distant organs. The purpose of this study was to determine whether nitric oxide (NO) would attenuate tumor cell adhesion (TCA) to naive or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efa5d72197a01cb299579f30089b794
https://doi.org/10.1007/bf00123392
https://doi.org/10.1007/bf00123392
Publikováno v:
Scopus-Elsevier
Two major roles have been defined for nitric oxide (NO): cell-cell communication mediated by the stimulation of cyclic guanosine 3',5'-monophosphate (cGMP) synthesis and cytotoxicity by direct or indirect interaction of the free radical NO with cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaef0a50439be057e8f04ef93cc743ab
https://doi.org/10.1165/ajrcmb.11.2.7519434
https://doi.org/10.1165/ajrcmb.11.2.7519434
Publikováno v:
ChemInform. 23
Selected mechanisms by which electrophiles can facilitate N-nitrosamine formation are reviewed. Special attention is given to a recently discovered reaction in which nitrogen in its lowest (ammonia) oxidation state is efficiently converted to N-nitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f76d1aa4602a6042de4e0220998e86
https://doi.org/10.1002/chin.199210322
https://doi.org/10.1002/chin.199210322
Autor:
L. K. Keefer
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c735d1de69448d8e6e0c0bac773a6c5
https://doi.org/10.1002/chin.199839311
https://doi.org/10.1002/chin.199839311
Nitric oxide (NO) is a major effector molecule in cancer prevention. A number of studies have shown that NO prodrug JS-K (O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate) induces apoptotic cell death in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15efd5c3e17fd279058c37543120462a
https://europepmc.org/articles/PMC2854646/
https://europepmc.org/articles/PMC2854646/
Autor:
C T, Noguchi, M, Gladwin, B, Diwan, P, Merciris, R, Smith, X, Yu, G, Buzard, A, Fitzhugh, L K, Keefer, A N, Schechter, N, Mohandas
Publikováno v:
Blood cells, moleculesdiseases. 27(6)
As a potential model for sickle cell trait (AS), we examined mice containing one normal mouse beta-globin allele in combination with a human hemoglobin S (h(alpha)beta(S)) transgene (m(beta)/hS). The mice segregated into two subpopulations containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0666b04e487204d531e182f1440ab21
https://pubmed.ncbi.nlm.nih.gov/11831863
https://pubmed.ncbi.nlm.nih.gov/11831863
Autor:
J E, Saavedra, A, Srinivasan, C L, Bonifant, J, Chu, A P, Shanklin, J L, Flippen-Anderson, W G, Rice, J A, Turpin, K M, Davies, L K, Keefer
Publikováno v:
The Journal of organic chemistry. 66(9)
Ions of structure R(2)N[N(O)NO](-) and their alkylation products have seen increasing use as nitric oxide (NO)-generating agents for biomedical research applications. Here we show that such diazeniumdiolate anions can readily displace halide from a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e65d27599df8fabf01909e13d2b14dfa
https://pubmed.ncbi.nlm.nih.gov/11325274
https://pubmed.ncbi.nlm.nih.gov/11325274
Publikováno v:
The Journal of biological chemistry. 276(20)
Proatherogenic oxidized low-density lipoprotein (oxLDL) induces endothelial apoptosis. We investigated the anti-apoptotic effects of intracellular and extracellular nitric oxide (*NO) donors, iron chelators, cell-permeable superoxide dismutase (SOD),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb698779239f740e1d424cf690b3aed6
https://pubmed.ncbi.nlm.nih.gov/11278975
https://pubmed.ncbi.nlm.nih.gov/11278975
Autor:
R, Ricciardi, D P, Foley, S H, Quarfordt, J E, Saavedra, L K, Keefer, S M, Wheeler, S E, Donohue, M P, Callery, W C, Meyers
Publikováno v:
Transplantation. 71(2)
The role of nitric oxide (NO) in ischemia reperfusion (I/R) injury is controversial as both beneficial and harmful effects have been reported. We explored the potential role of a pharmacological agent recently shown to generate NO metabolically in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4624a0afa7833e7f0058fe190ab56fb2
https://pubmed.ncbi.nlm.nih.gov/11213058
https://pubmed.ncbi.nlm.nih.gov/11213058