Zobrazeno 1 - 10
of 23
pro vyhledávání: '"L K Jolliffe"'
Autor:
V L Pulito, V A Roberts, J R Adair, A L Rothermel, A M Collins, S S Varga, C Martocello, M Bodmer, L K Jolliffe, R A Zivin
Publikováno v:
The Journal of Immunology. 156:2840-2850
OKT4A, a murine mAb that recognizes an epitope on the CD4 receptor, is a potent immunosuppressive agent in vitro and in a variety of nonhuman primate models of graft rejection and autoimmune disease. Initial human cardiac transplant trials suggest th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf77649c606ea2b414be381a76794a5d
https://doi.org/10.4049/jimmunol.156.8.2840
https://doi.org/10.4049/jimmunol.156.8.2840
Autor:
R. A. Zivin, D R Jeyarajah, L K Jolliffe, Danlin Xu, Husain Sattar, J. R. Thistlethwaite, Maria-Luisa Alegre, K. Kowalkowski, Jeffrey A. Bluestone, L. J. Peterson
Publikováno v:
Transplantation. 57:1537-1543
OKT3, a mouse anti-human CD3 mAb, is a potent immunosuppressive agent used in clinical transplantation to prevent or treat allograft rejection. Associated with this therapy is the systemic release of several cytokines that result in a series of adver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::165d1f0260c1a46d071230905d0b19f2
https://doi.org/10.1097/00007890-199457110-00001
https://doi.org/10.1097/00007890-199457110-00001
Autor:
M L Alegre, A M Collins, V L Pulito, R A Brosius, W C Olson, R A Zivin, R Knowles, J R Thistlethwaite, L K Jolliffe, J A Bluestone
Publikováno v:
The Journal of Immunology. 148:3461-3468
The binding specificity of the murine OKT3 has been transferred into a human antibody framework to reduce its immunogenicity. This "humanized" anti-CD3 mAb (gOKT3-5) was previously shown to retain, in vitro, all the properties of native OKT3, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f51855c77c66e312d0dec9fdadbbd2
https://doi.org/10.4049/jimmunol.148.11.3461
https://doi.org/10.4049/jimmunol.148.11.3461
Autor:
A J Fucello, L K Jolliffe, E. S. Woodle, J. R. Thistlethwaite, Frank P. Stuart, Jeffrey A. Bluestone
Publikováno v:
Transplantation. 52:361-368
Several problems remain associated with anti-CD3 monoclonal antibody therapy, including first-dose reactions, recurrent rejection, and the host humoral response to the xenogeneic mAb. One approach toward optimization of anti-CD3 mAb therapy involves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2110ca7873ce4f6544f3e5860c05f2a3
https://doi.org/10.1097/00007890-199108000-00034
https://doi.org/10.1097/00007890-199108000-00034
Autor:
V L, Pulito, X, Li, S S, Varga, L S, Mulcahy, K S, Clark, S A, Halbert, A B, Reitz, W V, Murray, L K, Jolliffe
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 294(1)
The development of alpha(1a)-adrenergic receptor (AR) subtype-selective antagonists is likely to result in uroselective agents that effectively treat benign prostatic hyperplasia (BPH) symptoms without causing undesirable side effects that may be due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::57858b050954acd54be4a2e7aded56de
https://pubmed.ncbi.nlm.nih.gov/10871316
https://pubmed.ncbi.nlm.nih.gov/10871316
Autor:
F P, Barbone, D L, Johnson, F X, Farrell, A, Collins, S A, Middleton, F J, McMahon, J, Tullai, L K, Jolliffe
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 14
Erythropoietin (EPO) is a 34 kDa protein that is the primary regulator of red blood cell production. EPO facilitates its effect by binding to the cell surface EPO receptor which initiates the JAK-STAT signal transduction cascade. The search for small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6e1e23a237c7792a5f1b7e195f8f2df
https://pubmed.ncbi.nlm.nih.gov/10334672
https://pubmed.ncbi.nlm.nih.gov/10334672
Autor:
F P, Barbone, S A, Middleton, D L, Johnson, F J, McMahon, J, Tullai, R H, Gruninger, A E, Schilling, L K, Jolliffe, L S, Mulcahy
Publikováno v:
The Journal of biological chemistry. 272(8)
Mutagenesis of the erythropoietin receptor (EPOR) permits analysis of the contribution that individual amino acid residues make to erythropoietin (EPO) binding. We employed both random and site-specific mutagenesis to determine the function of amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9de7fe75b12df0326baf776907933b7
https://pubmed.ncbi.nlm.nih.gov/9030560
https://pubmed.ncbi.nlm.nih.gov/9030560
Autor:
S A, Middleton, D L, Johnson, R, Jin, F J, McMahon, A, Collins, J, Tullai, R H, Gruninger, L K, Jolliffe, L S, Mulcahy
Publikováno v:
The Journal of biological chemistry. 271(24)
The erythropoietin receptor (EPOR) is a member of a family of cytokine and growth factor receptors that share conserved features in their extracellular and cytoplasmic domains. We have used site-specific mutagenesis within the extracellular domain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc7974fc6986e4c33475f3bcd7fdccdc
https://pubmed.ncbi.nlm.nih.gov/8662939
https://pubmed.ncbi.nlm.nih.gov/8662939
Autor:
V L, Pulito, V A, Roberts, J R, Adair, A L, Rothermel, A M, Collins, S S, Varga, C, Martocello, M, Bodmer, L K, Jolliffe, R A, Zivin
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(8)
OKT4A, a murine mAb that recognizes an epitope on the CD4 receptor, is a potent immunosuppressive agent in vitro and in a variety of nonhuman primate models of graft rejection and autoimmune disease. Initial human cardiac transplant trials suggest th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bea1cddbebff22ca3395c90c192cfb19
https://pubmed.ncbi.nlm.nih.gov/8609403
https://pubmed.ncbi.nlm.nih.gov/8609403
Publikováno v:
Experimental hematology. 23(10)
Human interleukin-3/erythropoietin (IL-3/Epo) fusion protein have been constructed, expressed, and tested for biological activity. These fusion proteins were previously shown to be active on erythroid progenitors (BFU-E) from unseparated human bone m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e571b08a078bf383a1638642bac25a0f
https://pubmed.ncbi.nlm.nih.gov/7656932
https://pubmed.ncbi.nlm.nih.gov/7656932